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Dhaifullah E, Seayed HS, Mostafa D, et al. Does Chemically Modified Curcumin Control the Progression of Periodontitis? A Systematic Review. J Exp Pharmacol. 2021;13:565-575doi: 10.2147/JEP.S313192.
Dhaifullah, E., Seayed, H. S., Mostafa, D., Alharbi, A. M. M., & Alotaibi, W. M. (2021). Does Chemically Modified Curcumin Control the Progression of Periodontitis? A Systematic Review. Journal of experimental pharmacology, 13565-575. https://doi.org/10.2147/JEP.S313192
Dhaifullah, Esam, et al. "Does Chemically Modified Curcumin Control the Progression of Periodontitis? A Systematic Review." Journal of experimental pharmacology vol. 13 (2021): 565-575. doi: https://doi.org/10.2147/JEP.S313192
Dhaifullah E, Seayed HS, Mostafa D, Alharbi AMM, Alotaibi WM. Does Chemically Modified Curcumin Control the Progression of Periodontitis? A Systematic Review. J Exp Pharmacol. 2021 Jun 09;13:565-575. doi: 10.2147/JEP.S313192. eCollection 2021. PMID: 34135646; PMCID: PMC8200174.
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J Exp Pharmacol. 2021 Jun 09;13:565-575. doi: 10.2147/JEP.S313192. eCollection 2021.

Does Chemically Modified Curcumin Control the Progression of Periodontitis? A Systematic Review.

Journal of experimental pharmacology

Esam Dhaifullah, Hassan S Seayed, Diana Mostafa, Abdul Majeed M Alharbi, Waleed M Alotaibi

Affiliations

  1. Department of Preventive Dental Sciences, Vision Colleges, Riyadh, Kingdom of Saudi Arabia.
  2. Clinical Periodontology Department, Faculty of Dentistry, Alexandria University, Alexandria, Egypt.

PMID: 34135646 PMCID: PMC8200174 DOI: 10.2147/JEP.S313192

Abstract

BACKGROUND: Recently, pharmacologic approaches have been seen in utilizing matrix metalloproteinase inhibitors (MMP-I) to prohibit the destruction of connective tissue accompanied by erythrogenic inflammatory diseases such as periodontitis. However, curcumin characteristics have been described to be effective in reducing inflammatory mediators and matrix metalloproteinase (MMP). But, due to its poor solubility and bioavailability, a chemically modified curcumin (CMC 2.24) has been used.

OBJECTIVE: The purpose of this research is to review and analyze the animal attempts which investigate the impact of CMC2.24 on periodontitis.

MATERIALS AND METHODS: Our study was based on reviewing the English preclinical studies using CMC2.24 on an induced periodontal disease which were published up to 2020, only randomized control trials (RCTs) were included. Databases were used from electronic websites including PubMed, ScienceDirect, and Google scholar.

RESULTS: Seven experimental trials involving 162 rats and 8 dogs were included in the present systematic review. Six studies investigated LPS-induced experimental periodontitis, two of them worked on diabetes-associated periodontitis, while one study worked on naturally occurring periodontitis. All included studies revealed that CMC 2.24 reduced alveolar bone loss as well as inhibited the MMP.

CONCLUSION: Collectively, we concluded that CMC 2.24 has significant implications in prohibiting the progression of bone loss.

© 2021 Dhaifullah et al.

Keywords: CMC2.24; chemically modified curcumin; cytokines; matrix metalloproteinase; periodontitis

Conflict of interest statement

The authors report no conflicts of interest in this work.

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