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Karpova R, Gorbunov A, Mnatsakanyan M, et al. Emergency Splenectomy in a Patient with Splenic Marginal Zone Lymphoma, Acute Portal Vein Thrombosis, and Chronic Viral Hepatitis B. J Blood Med. 2021;12:431-434doi: 10.2147/JBM.S283098.
Karpova, R., Gorbunov, A., Mnatsakanyan, M., Pogromov, A., Sokolova, I., Shumskaya, Y., Russkova, K., Chernousov, K., & Momatyuk, D. (2021). Emergency Splenectomy in a Patient with Splenic Marginal Zone Lymphoma, Acute Portal Vein Thrombosis, and Chronic Viral Hepatitis B. Journal of blood medicine, 12431-434. https://doi.org/10.2147/JBM.S283098
Karpova, Radmila, et al. "Emergency Splenectomy in a Patient with Splenic Marginal Zone Lymphoma, Acute Portal Vein Thrombosis, and Chronic Viral Hepatitis B." Journal of blood medicine vol. 12 (2021): 431-434. doi: https://doi.org/10.2147/JBM.S283098
Karpova R, Gorbunov A, Mnatsakanyan M, Pogromov A, Sokolova I, Shumskaya Y, Russkova K, Chernousov K, Momatyuk D. Emergency Splenectomy in a Patient with Splenic Marginal Zone Lymphoma, Acute Portal Vein Thrombosis, and Chronic Viral Hepatitis B. J Blood Med. 2021 Jun 09;12:431-434. doi: 10.2147/JBM.S283098. eCollection 2021. PMID: 34135652; PMCID: PMC8200168.
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J Blood Med. 2021 Jun 09;12:431-434. doi: 10.2147/JBM.S283098. eCollection 2021.

Emergency Splenectomy in a Patient with Splenic Marginal Zone Lymphoma, Acute Portal Vein Thrombosis, and Chronic Viral Hepatitis B.

Journal of blood medicine

Radmila Karpova, Andrey Gorbunov, Marina Mnatsakanyan, Aleksandr Pogromov, Irina Sokolova, Yuliya Shumskaya, Ksenia Russkova, Kirill Chernousov, Daria Momatyuk

Affiliations

  1. Department of Faculty Surgery No.1, University Clinical Hospital No.1, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
  2. Department of Hospital Therapy No.1, University Clinical Hospital No.1, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
  3. Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.

PMID: 34135652 PMCID: PMC8200168 DOI: 10.2147/JBM.S283098

Abstract

Splenic marginal zone lymphoma (SMZL) is a type of non-Hodgkin's lymphoma (NL) that occurs in 2 out of 100 cases and is more common in women aged >60 years. A sluggish, asymptomatic course of the disease does not exclude transformation into a malignant form that occurs in 25% of patients with SMZL. Another equally important sign of an NL is thrombosis that occurs in 3.6% to 17.1% of the cases. In this report, we present a case of emergency splenectomy in a patient owing to difficulties in the diagnosis of SMZL, rapid onset of acute portal vein thrombosis, and the fulminant enlargement of the spleen accompanied by an increased risk of its rupture. Chronic hepatitis B was likely the trigger for transformation of the disease to an aggressive course. Portal vein thrombosis and the aggressive course of SMZL with rapid enlargement of the spleen and threat of its rupture in the background of viral hepatitis B required emergency splenectomy followed by anticoagulant, antiviral, and antitumor therapy.

© 2021 Karpova et al.

Keywords: SMZL; chronic viral hepatitis B; emergency splenectomy; portal vein thrombosis; splenic marginal zone lymphoma

Conflict of interest statement

The authors report no conflicts of interest in this work. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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