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You XY, Zhang HY, Han X, et al. Intestinal Mucosal Barrier Is Regulated by Intestinal Tract Neuro-Immune Interplay. Front Pharmacol. 2021;12:659716doi: 10.3389/fphar.2021.659716.
You, X. Y., Zhang, H. Y., Han, X., Wang, F., Zhuang, P. W., & Zhang, Y. J. (2021). Intestinal Mucosal Barrier Is Regulated by Intestinal Tract Neuro-Immune Interplay. Frontiers in pharmacology, 12659716. https://doi.org/10.3389/fphar.2021.659716
You, Xin-Yu, et al. "Intestinal Mucosal Barrier Is Regulated by Intestinal Tract Neuro-Immune Interplay." Frontiers in pharmacology vol. 12 (2021): 659716. doi: https://doi.org/10.3389/fphar.2021.659716
You XY, Zhang HY, Han X, Wang F, Zhuang PW, Zhang YJ. Intestinal Mucosal Barrier Is Regulated by Intestinal Tract Neuro-Immune Interplay. Front Pharmacol. 2021 May 31;12:659716. doi: 10.3389/fphar.2021.659716. eCollection 2021. PMID: 34135754; PMCID: PMC8201607.
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Front Pharmacol. 2021 May 31;12:659716. doi: 10.3389/fphar.2021.659716. eCollection 2021.

Intestinal Mucosal Barrier Is Regulated by Intestinal Tract Neuro-Immune Interplay.

Frontiers in pharmacology

Xin-Yu You, Han-Yu Zhang, Xu Han, Fang Wang, Peng-Wei Zhuang, Yan-Jun Zhang

Affiliations

  1. Tianjin Key Laboratory of Chinese medicine Pharmacology, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
  2. State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.

PMID: 34135754 PMCID: PMC8201607 DOI: 10.3389/fphar.2021.659716

Abstract

Inflammatory bowel disease, irritable bowel syndrome and severe central nervous system injury can lead to intestinal mucosal barrier damage, which can cause endotoxin/enterobacteria translocation to induce infection and is closely related to the progression of metabolic diseases, cardiovascular and cerebrovascular diseases, tumors and other diseases. Hence, repairing the intestinal barrier represents a potential therapeutic target for many diseases. Enteral afferent nerves, efferent nerves and the intrinsic enteric nervous system (ENS) play key roles in regulating intestinal physiological homeostasis and coping with acute stress. Furthermore, innervation actively regulates immunity and induces inherent and adaptive immune responses through complex processes, such as secreting neurotransmitters or hormones and regulating their corresponding receptors. In addition, intestinal microorganisms and their metabolites play a regulatory role in the intestinal mucosal barrier. This paper primarily discusses the interactions between norepinephrine and β-adrenergic receptors, cholinergic anti-inflammatory pathways, nociceptive receptors, complex ENS networks, gut microbes and various immune cells with their secreted cytokines to summarize the key roles in regulating intestinal inflammation and improving mucosal barrier function.

Copyright © 2021 You, Zhang, Han, Wang, Zhuang and Zhang.

Keywords: cholinergic anti-inflammatory pathway; enteric nervous system; gut microbes; immunity; norepinephrine; sensory neurone

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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