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Toffoli EC, Sweegers MG, Bontkes HJ, et al. Effects of physical exercise on natural killer cell activity during (neo)adjuvant chemotherapy: A randomized pilot study. Physiol Rep. 2021;9(11):e14919doi: 10.14814/phy2.14919.
Toffoli, E. C., Sweegers, M. G., Bontkes, H. J., Altenburg, T. M., Verheul, H. M. W., van der Vliet, H. J., de Gruijl, T. D., & Buffart, L. M. (2021). Effects of physical exercise on natural killer cell activity during (neo)adjuvant chemotherapy: A randomized pilot study. Physiological reports, 9(11), e14919. https://doi.org/10.14814/phy2.14919
Toffoli, Elisa C, et al. "Effects of physical exercise on natural killer cell activity during (neo)adjuvant chemotherapy: A randomized pilot study." Physiological reports vol. 9,11 (2021): e14919. doi: https://doi.org/10.14814/phy2.14919
Toffoli EC, Sweegers MG, Bontkes HJ, Altenburg TM, Verheul HMW, van der Vliet HJ, de Gruijl TD, Buffart LM. Effects of physical exercise on natural killer cell activity during (neo)adjuvant chemotherapy: A randomized pilot study. Physiol Rep. 2021 Jun;9(11):e14919. doi: 10.14814/phy2.14919. PMID: 34110712; PMCID: PMC8191403.
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Physiol Rep. 2021 Jun;9(11):e14919. doi: 10.14814/phy2.14919.

Effects of physical exercise on natural killer cell activity during (neo)adjuvant chemotherapy: A randomized pilot study.

Physiological reports

Elisa C Toffoli, Maike G Sweegers, Hetty J Bontkes, Teatske M Altenburg, Henk M W Verheul, Hans J van der Vliet, Tanja D de Gruijl, Laurien M Buffart

Affiliations

  1. Department of Medical Oncology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
  2. Department of Epidemiology and Biostatistics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Public Health, Amsterdam, The Netherlands.
  3. Department of Clinical Chemistry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
  4. Department of Public and Occupational Health, Amsterdam Public Health Research Institute, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
  5. Department of Medical Oncology, Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands.
  6. Lava Therapeutics, Utrecht, Netherlands.
  7. Department of Physiology, Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands.

PMID: 34110712 PMCID: PMC8191403 DOI: 10.14814/phy2.14919

Abstract

Natural killer (NK) cells are a population of innate immune cells known to play a pivotal role against tumor spread. In multiple murine models, it was shown that physical exercise had the potential to increase NK cell antitumor activity through their mobilization and tissue redistribution in an interleukin (IL)-6 and epinephrine-dependent manner. The translation of this finding to patients is unclear. In this randomized pilot trial, we analyzed blood samples of patients with resectable breast or colon cancer who were randomized into an evidence-based moderate-high intensity resistance and aerobic exercise intervention (n = 8) or a control group (n = 6) during the first 9-12 weeks of (neo)adjuvant chemotherapy. In this pilot, we did not solely focus on statistical significance, but also explored whether average between-group differences reached 10%. NK cell degranulation was preserved in the exercise group whereas it decreased in the control group resulting in a between-group difference of 11.4% CD107a

© 2021 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.

Keywords: NK cell activity; cancer; chemotherapy; natural killer cells; physical exercise

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