Display options
Cite
Prasanth MI, Malar DS, Tencomnao T, et al. The emerging role of the sigma-1 receptor in autophagy: hand-in-hand targets for the treatment of Alzheimer's. Expert Opin Ther Targets. 2021;25(5):401-414doi: 10.1080/14728222.2021.1939681.
Prasanth, M. I., Malar, D. S., Tencomnao, T., & Brimson, J. M. (2021). The emerging role of the sigma-1 receptor in autophagy: hand-in-hand targets for the treatment of Alzheimer's. Expert opinion on therapeutic targets, 25(5), 401-414. https://doi.org/10.1080/14728222.2021.1939681
Prasanth, Mani Iyer, et al. "The emerging role of the sigma-1 receptor in autophagy: hand-in-hand targets for the treatment of Alzheimer's." Expert opinion on therapeutic targets vol. 25,5 (2021): 401-414. doi: https://doi.org/10.1080/14728222.2021.1939681
Prasanth MI, Malar DS, Tencomnao T, Brimson JM. The emerging role of the sigma-1 receptor in autophagy: hand-in-hand targets for the treatment of Alzheimer's. Expert Opin Ther Targets. 2021 May;25(5):401-414. doi: 10.1080/14728222.2021.1939681. Epub 2021 Jun 17. PMID: 34110944.
Copy Download .nbib Format: NLM
Share it on

Expert Opin Ther Targets. 2021 May;25(5):401-414. doi: 10.1080/14728222.2021.1939681. Epub 2021 Jun 17.

The emerging role of the sigma-1 receptor in autophagy: hand-in-hand targets for the treatment of Alzheimer's.

Expert opinion on therapeutic targets

Mani Iyer Prasanth, Dicson Sheeja Malar, Tewin Tencomnao, James Michael Brimson

Affiliations

  1. Natural Products for Neuroprotection and Anti-ageing Research Unit, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, Thailand.
  2. Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, Thailand.

PMID: 34110944 DOI: 10.1080/14728222.2021.1939681

Abstract

INTRODUCTION: Autophagy is a cellular catabolic mechanism that helps clear damaged cellular components and is essential for normal cellular and tissue function. The sigma-1 receptor (σ-1R) is a chaperone protein involved in signal transduction, neurite outgrowth, and plasticity, improving memory, and neuroprotection. Recent evidence shows that σ-1R can promote autophagy. Autophagy activation by the σ-1Rs along with other neuroprotective effects makes it an interesting target for the treatment of Alzheimer's disease. AF710B, T-817 MA, and ANAVEX2-73 are some of the σ-1R agonists which have shown promising results and have entered clinical trials. These molecules have also been found to induce autophagy and show cytoprotective effects in cellular models.

AREAS COVERED: This review provides insight into the current understanding of σ-1R functions related to autophagy and their role in alleviating AD.

EXPERT OPINION: We propose a mechanism through which the activation of σ-1R and autophagy could alter amyloid precursor protein processing to inhibit amyloid-β production by reconstituting cholesterol and gangliosides in the lipid raft to offer neuroprotection against AD. Future AD treatment could involve the combined targeting of the σ-1R and autophagy activation. We suggest that future studies investigate the link between autophagy the σ-1R and AD.

Keywords: Alzheimer’s disease; anavex2-73; autophagy; avp-786; lipid raft; mitochondrial stress; neurodegenerative disease; non-opioid-sigma-1 receptor; sigma-1 agonists; sigma-1 receptor

Publication Types