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Traby L, Kollars M, Kussmann M, et al. Extracellular Vesicles and Citrullinated Histone H3 in Coronavirus Disease 2019 Patients. Thromb Haemost. 2021;doi: 10.1055/a-1522-4131.
Traby, L., Kollars, M., Kussmann, M., Karer, M., Šinkovec, H., Lobmeyr, E., Hermann, A., Staudinger, T., Schellongowski, P., Rössler, B., Burgmann, H., Kyrle, P. A., & Eichinger, S. (2021). Extracellular Vesicles and Citrullinated Histone H3 in Coronavirus Disease 2019 Patients. Thrombosis and haemostasis, . https://doi.org/10.1055/a-1522-4131
Traby, Ludwig, et al. "Extracellular Vesicles and Citrullinated Histone H3 in Coronavirus Disease 2019 Patients." Thrombosis and haemostasis vol. (2021). doi: https://doi.org/10.1055/a-1522-4131
Traby L, Kollars M, Kussmann M, Karer M, Šinkovec H, Lobmeyr E, Hermann A, Staudinger T, Schellongowski P, Rössler B, Burgmann H, Kyrle PA, Eichinger S. Extracellular Vesicles and Citrullinated Histone H3 in Coronavirus Disease 2019 Patients. Thromb Haemost. 2021 Jun 02; doi: 10.1055/a-1522-4131. Epub 2021 Jun 02. PMID: 34077977.
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Thromb Haemost. 2021 Jun 02; doi: 10.1055/a-1522-4131. Epub 2021 Jun 02.

Extracellular Vesicles and Citrullinated Histone H3 in Coronavirus Disease 2019 Patients.

Thrombosis and haemostasis

Ludwig Traby, Marietta Kollars, Manuel Kussmann, Matthias Karer, Hana Šinkovec, Elisabeth Lobmeyr, Alexander Hermann, Thomas Staudinger, Peter Schellongowski, Bernhard Rössler, Heinz Burgmann, Paul A Kyrle, Sabine Eichinger

Affiliations

  1. Department of Medicine I, Medical University of Vienna, Vienna, Austria.
  2. Section for Clinical Biometrics, Center for Medical Statistics, Informatics and Intelligent Systems, Medical University of Vienna, Vienna, Austria.
  3. Medical Simulation and Emergency Management Research Group, Department of Anesthesia, Intensive Care Medicine and Pain Medicine, Medical University of Vienna, Vienna, Austria.

PMID: 34077977 DOI: 10.1055/a-1522-4131

Abstract

OBJECTIVES:  Pulmonary thrombus formation is a hallmark of coronavirus disease 2019 (COVID-19). A dysregulated immune response culminating in thromboinflammation has been described, but the pathomechanisms remain unclear.

METHODS:  We studied 41 adult COVID-19 patients with positive results on reverse-transcriptase polymerase-chain-reaction assays and 37 sex- and age-matched healthy controls. Number and surface characteristics of extracellular vesicles (EVs) and citrullinated histone H3 levels were determined in plasma upon inclusion by flow cytometry and immunoassay.

RESULTS:  In total, 20 patients had severe and 21 nonsevere disease. The number of EV (median [25th, 75th percentile]) was significantly higher in patients compared with controls (658.8 [353.2, 876.6] vs. 435.5 [332.5, 585.3], geometric mean ratio [95% confidence intervals]: 2.6 [1.9, 3.6];

CONCLUSION:  EV and citrullinated histone H3 are associated with COVID-19 and could provide information regarding pathophysiology of the disease.

Thieme. All rights reserved.

Conflict of interest statement

None declared.

Publication Types

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