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Hoxha E, Balbo I, Parolisi R, et al. Elovl5 is required for proper action potential conduction along peripheral myelinated fibers. Glia. 2021;69(10):2419-2428doi: 10.1002/glia.24048.
Hoxha, E., Balbo, I., Parolisi, R., Audano, M., Montarolo, F., Ravera, F., Guglielmotto, M., Muratori, L., Raimondo, S., DiGregorio, E., Buffo, A., Brusco, A., Borroni, B., Mitro, N., Caruso, D., & Tempia, F. (2021). Elovl5 is required for proper action potential conduction along peripheral myelinated fibers. Glia, 69(10), 2419-2428. https://doi.org/10.1002/glia.24048
Hoxha, Eriola, et al. "Elovl5 is required for proper action potential conduction along peripheral myelinated fibers." Glia vol. 69,10 (2021): 2419-2428. doi: https://doi.org/10.1002/glia.24048
Hoxha E, Balbo I, Parolisi R, Audano M, Montarolo F, Ravera F, Guglielmotto M, Muratori L, Raimondo S, DiGregorio E, Buffo A, Brusco A, Borroni B, Mitro N, Caruso D, Tempia F. Elovl5 is required for proper action potential conduction along peripheral myelinated fibers. Glia. 2021 Oct;69(10):2419-2428. doi: 10.1002/glia.24048. Epub 2021 Jun 17. PMID: 34139039; PMCID: PMC8453547.
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Glia. 2021 Oct;69(10):2419-2428. doi: 10.1002/glia.24048. Epub 2021 Jun 17.

Elovl5 is required for proper action potential conduction along peripheral myelinated fibers.

Glia

Eriola Hoxha, Ilaria Balbo, Roberta Parolisi, Matteo Audano, Francesca Montarolo, Francesco Ravera, Michela Guglielmotto, Luisa Muratori, Stefania Raimondo, Eleonora DiGregorio, Annalisa Buffo, Alfredo Brusco, Barbara Borroni, Nico Mitro, Donatella Caruso, Filippo Tempia

Affiliations

  1. Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano, Italy.
  2. Department of Neuroscience, University of Torino, Torino, Italy.
  3. Department. of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy.
  4. Department of Clinical and Biological Sciences, University of Torino, Torino, Italy.
  5. Medical Genetics Unit, Città della Salute e della Scienza Hospital and Dept. of Medical Sciences, University of Torino, Torino, Italy.
  6. Centre for Neurodegenerative Disorders, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
  7. National Neuroscience Institute, Torino, Italy.

PMID: 34139039 PMCID: PMC8453547 DOI: 10.1002/glia.24048

Abstract

Elovl5 elongates fatty acids with 18 carbon atoms and in cooperation with other enzymes guarantees the normal levels of very long-chain fatty acids, which are necessary for a proper membrane structure. Action potential conduction along myelinated axons depends on structural integrity of myelin, which is maintained by a correct amount of fatty acids and a proper interaction between fatty acids and myelin proteins. We hypothesized that in Elovl5

© 2021 The Authors. GLIA published by Wiley Periodicals LLC.

Keywords: Elovl5; action potential; axon; myelin; polyunsaturated fatty acids

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