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Albillos SM, Montero O, Calvo S, et al. Can Plasma α-Synuclein Help Us to Differentiate Parkinson's Disease from Essential Tremor?. Tremor Other Hyperkinet Mov (N Y). 2021;11:20doi: 10.5334/tohm.600.
Albillos, S. M., Montero, O., Calvo, S., Solano, B., Trejo, J. M., & Cubo, E. (2021). Can Plasma α-Synuclein Help Us to Differentiate Parkinson's Disease from Essential Tremor?. Tremor and other hyperkinetic movements (New York, N.Y.), 1120. https://doi.org/10.5334/tohm.600
Albillos, Silvia M, et al. "Can Plasma α-Synuclein Help Us to Differentiate Parkinson's Disease from Essential Tremor?." Tremor and other hyperkinetic movements (New York, N.Y.) vol. 11 (2021): 20. doi: https://doi.org/10.5334/tohm.600
Albillos SM, Montero O, Calvo S, Solano B, Trejo JM, Cubo E. Can Plasma α-Synuclein Help Us to Differentiate Parkinson's Disease from Essential Tremor?. Tremor Other Hyperkinet Mov (N Y). 2021 May 28;11:20. doi: 10.5334/tohm.600. PMID: 34113478; PMCID: PMC8162285.
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Tremor Other Hyperkinet Mov (N Y). 2021 May 28;11:20. doi: 10.5334/tohm.600.

Can Plasma α-Synuclein Help Us to Differentiate Parkinson's Disease from Essential Tremor?.

Tremor and other hyperkinetic movements (New York, N.Y.)

Silvia M Albillos, Olimpio Montero, Sara Calvo, Berta Solano, José María Trejo, Esther Cubo

Affiliations

  1. Area of Biochemistry and Molecular Biology, University of Burgos, Pza. Misael Bañuelos s/n. 09001, Burgos, Spain.
  2. Consejo Superior de Investigaciones Científicas (CSIC). Av. Francisco Vallés, 8. 47151 - Boecillo (Valladolid), Spain.
  3. Research Unit of the Universitary Hospital of Burgos. Avda. de las Islas Baleares, 3. 09006, Burgos, Spain.
  4. Neurology Department of the Universitary Hospital Josep Trueta. Avinguda de França, S/N, 17007 Girona, Spain.
  5. Avda. de las Islas Baleares, 3. 09006, Burgos, Avda. de las Islas Baleares, 3. 09006, Burgos, Spain.

PMID: 34113478 PMCID: PMC8162285 DOI: 10.5334/tohm.600

Abstract

BACKGROUND: Studies have revealed controversial results regarding the diagnostic accuracy of plasma α-synuclein levels in patients with Parkinson's disease (PD). This study was aimed to analyze the diagnostic accuracy of plasma α-synuclein in PD versus healthy controls and patients with essential tremor (ET).

METHODS: In this cross-sectional study, we included de novo (n = 19) and advanced PD patients [OFF (n = 33), and On (n = 35) states], patients with ET (n = 19), and controls (n = 35). The total plasma α-synuclein levels were determined using an ELISA sandwich method. We performed adjusted multivariate regression analysis to estimate the association of α-synuclein levels with group conditions [controls, ET, and de novo, OFF and ON-PD]. We studied the diagnostic accuracy of plasma α-synuclein using the area under the curve (AUC).

RESULTS: The plasma α-synuclein levels were higher in controls compared to PD and ET (p < 0.0001), discriminating de novo PD from controls (AUC = 0.74, 95% CI 0.60-0.89), with a trend towards in advanced PD (OFF state) from ET (AUC = 0.69, 95% CI 0.53-0.84).

CONCLUSIONS: This is the first study examining and comparing plasma α-synuclein levels in ET vs. PD and controls. Preliminary findings suggest that plasma α-synuclein levels might help to discriminate de novo and advanced PD from controls and ET.

Copyright: © 2021 The Author(s).

Keywords: Essential tremor; Parkinson’s disease; alpha-synuclein; diagnosis; plasma biomarker

Conflict of interest statement

The authors have no competing interests to declare.

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