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Blight BJ, Gill AS, Sumsion JS, et al. Cell Adhesion Molecules are Upregulated and May Drive Inflammation in Chronic Rhinosinusitis with Nasal Polyposis. J Asthma Allergy. 2021;14:585-593doi: 10.2147/JAA.S307197.
Blight, B. J., Gill, A. S., Sumsion, J. S., Pollard, C. E., Ashby, S., Oakley, G. M., Alt, J. A., & Pulsipher, A. (2021). Cell Adhesion Molecules are Upregulated and May Drive Inflammation in Chronic Rhinosinusitis with Nasal Polyposis. Journal of asthma and allergy, 14585-593. https://doi.org/10.2147/JAA.S307197
Blight, Brennan J, et al. "Cell Adhesion Molecules are Upregulated and May Drive Inflammation in Chronic Rhinosinusitis with Nasal Polyposis." Journal of asthma and allergy vol. 14 (2021): 585-593. doi: https://doi.org/10.2147/JAA.S307197
Blight BJ, Gill AS, Sumsion JS, Pollard CE, Ashby S, Oakley GM, Alt JA, Pulsipher A. Cell Adhesion Molecules are Upregulated and May Drive Inflammation in Chronic Rhinosinusitis with Nasal Polyposis. J Asthma Allergy. 2021 May 27;14:585-593. doi: 10.2147/JAA.S307197. eCollection 2021. PMID: 34079296; PMCID: PMC8166329.
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J Asthma Allergy. 2021 May 27;14:585-593. doi: 10.2147/JAA.S307197. eCollection 2021.

Cell Adhesion Molecules are Upregulated and May Drive Inflammation in Chronic Rhinosinusitis with Nasal Polyposis.

Journal of asthma and allergy

Brennan J Blight, Amarbir S Gill, Jorgen S Sumsion, Chelsea E Pollard, Shaelene Ashby, Gretchen M Oakley, Jeremiah A Alt, Abigail Pulsipher

Affiliations

  1. Division of Otolaryngology-Head and Neck Surgery, Rhinology-Sinus and Skull Base Surgery Program, Department of Surgery, University of Utah School of Medicine, Salt Lake City, UT, USA.

PMID: 34079296 PMCID: PMC8166329 DOI: 10.2147/JAA.S307197

Abstract

PURPOSE: Chronic rhinosinusitis with nasal polyps (CRSwNP) is predominantly characterized by eosinophil- and T helper 2 cell (Th2)-biased inflammation. Integrins and intercellular adhesion molecules (ICAMs) are superfamilies of cell adhesion molecules (CAMs) that facilitate the recruitment and trafficking of immune cells and have been implicated in coordinating eosinophil and Th2 cell adhesion and signaling in asthma. The roles of CAMs in CRSwNP, however, remain poorly understood. The purpose of this study was to characterize the systemic and local expression of CAMs and identify which CAMs are potentially involved in CRSwNP pathology.

MATERIALS AND METHODS: A prospective observational study was conducted using peripheral blood and anterior ethmoid tissues of patients with CRSwNP (n=32) and controls (n=15). Multiplex gene analysis and Pearson correlations were performed to identify associations between systemically and locally expressed CAMs. Based on the gene expression results, immunohistochemical evaluation and quantification of cells expressing integrins ITGAM, ITGAX, and ITGB2, as well as ICAM-3 in sinonasal tissues were conducted to compare local protein expression patterns.

RESULTS: Integrin and ICAM genes were significantly elevated in the blood (

CONCLUSION: The systemic and local expression of ITGAM, ITGB2, and ICAM-3 is significantly upregulated in CRSwNP, suggesting that integrin complex ITGAM/ITGB2 and ICAM-3 serve a potential role in inflammation-mediated signaling in CRSwNP.

© 2021 Blight et al.

Keywords: Th2 pathophysiology; allergy; asthma; integrins; intercellular adhesion molecule 3; macrophage-1 antigen; transcriptional analysis

Conflict of interest statement

A. P. and J. A. A. have a financial interest in GlycoMira Therapeutics (Salt Lake City, UT). J. A. A. reports personal fees from Optinose and Medtronic, outside the submitted work, is a consultant for

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