Mol Cells. 2021 Jul 31;44(7):529-537. doi: 10.14348/molcells.2021.0051.

The FMRFamide Neuropeptide FLP-20 Acts as a Systemic Signal for Starvation Responses in .

Molecules and cells

Chanhee Kang, Leon Avery

PMID: 34140426 PMCID: PMC8334353 DOI: 10.14348/molcells.2021.0051

Abstract

Most animals face frequent periods of starvation throughout their entire life and thus need to appropriately adjust their behavior and metabolism during starvation for their survival. Such adaptive responses are regulated by a complex set of systemic signals, including hormones and neuropeptides. While much progress has been made in identifying pathways that regulate nutrient-excessive states, it is still incompletely understood how animals systemically signal their nutrient-deficient states. Here, we showed that the FMRFamide neuropeptide FLP-20 modulates a systemic starvation response in

Keywords: autophagy; metabotropic glutamate receptor; neuropeptide; nutrient-deficient states; receptor-type guanylate cyclase; starvation response; systemic regulation

References

1. Dev Cell. 2019 Mar 11;48(5):659-671.e4 - PubMed
2. Cell Metab. 2012 Aug 8;16(2):144-52 - PubMed
3. WormBook. 2008 Sep 25;:1-36 - PubMed
4. J Comp Neurol. 2004 Aug 2;475(4):540-50 - PubMed
5. Genes Dev. 2007 Nov 15;21(22):2861-73 - PubMed
6. Cell Metab. 2008 Jul;8(1):77-83 - PubMed
7. Genetics. 1974 May;77(1):71-94 - PubMed
8. Cell Metab. 2009 Apr;9(4):375-85 - PubMed
9. Mol Cells. 2020 Aug 31;43(8):686-693 - PubMed
10. Genetics. 2006 May;173(1):131-49 - PubMed
11. Dev Cell. 2020 Nov 9;55(3):289-297.e4 - PubMed
12. Science. 2003 Sep 5;301(5638):1387-91 - PubMed
13. Dev Cell. 2020 Jul 20;54(2):226-238 - PubMed
14. Cell Metab. 2006 Apr;3(4):237-45 - PubMed
15. Nat Commun. 2020 Feb 10;11(1):807 - PubMed
16. Science. 2009 Nov 13;326(5955):954-8 - PubMed
17. Mol Cells. 2020 Jan 31;43(1):10-22 - PubMed
18. Neuron. 2008 Sep 25;59(6):959-71 - PubMed
19. Genes Dev. 2009 Jan 1;23(1):12-7 - PubMed
20. Dev Cell. 2015 May 4;33(3):260-71 - PubMed
21. Dev Cell. 2019 Sep 9;50(5):627-643.e5 - PubMed
22. Autophagy. 2009 May;5(4):565-6 - PubMed
23. Nutrition. 2006 Jul-Aug;22(7-8):830-44 - PubMed
24. Nature. 1996 Jul 18;382(6588):250-2 - PubMed
25. Proc Natl Acad Sci U S A. 2006 May 9;103(19):7438-43 - PubMed
26. Mol Cells. 2017 Sep 30;40(9):607-612 - PubMed
27. Dev Cell. 2016 Oct 24;39(2):209-223 - PubMed
28. Dev Cell. 2017 Apr 10;41(1):10-22 - PubMed
29. Autophagy. 2016;12(1):1-222 - PubMed
30. Genes Dev. 2009 Feb 15;23(4):496-511 - PubMed
31. Genes Dev. 2008 Aug 15;22(16):2149-65 - PubMed
32. Trends Endocrinol Metab. 2010 Feb;21(2):68-74 - PubMed
33. Adv Cancer Res. 2021;150:75-112 - PubMed
34. Mol Cells. 2018 Jan 31;41(1):11-17 - PubMed
35. Autophagy. 2015;11(1):9-27 - PubMed
36. Dev Cell. 2003 Jan;4(1):131-42 - PubMed
37. Cell Metab. 2008 Jun;7(6):533-44 - PubMed
38. Dev Cell. 2021 Apr 5;56(7):906-918 - PubMed
39. Cell Metab. 2007 Jun;5(6):426-37 - PubMed
40. Dev Cell. 2020 Jul 20;54(2):268-281 - PubMed
41. J Physiol. 2009 Apr 1;587(Pt 7):1593-605 - PubMed
42. Mol Cells. 2019 Jan 31;42(1):28-35 - PubMed
43. Genes Dev. 2007 Sep 1;21(17):2161-71 - PubMed
44. Lancet. 2005 Jul 2-8;366(9479):74-85 - PubMed
45. Dev Cell. 2021 May 17;56(10):1417-1429 - PubMed
46. J Clin Invest. 2015 Nov 03;125(12):4601-11 - PubMed
47. Cell Metab. 2008 Aug;8(2):118-31 - PubMed
48. Cell Metab. 2009 May;9(5):440-8 - PubMed
49. Autophagy. 2008 Jan;4(1):82-4 - PubMed
50. Trends Neurosci. 2005 Dec;28(12):644-52 - PubMed
51. J Endocrinol. 2007 Jan;192(1):3-15 - PubMed
52. Dev Cell. 2021 Apr 5;56(7):949-966 - PubMed
53. Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13496-501 - PubMed
54. Annu Rev Psychol. 2008;59:55-92 - PubMed
55. Annu Rev Physiol. 2006;68:223-51 - PubMed
56. J Clin Invest. 2003 May;111(9):1409-21 - PubMed
57. Dev Cell. 2021 May 17;56(10):1512-1525.e7 - PubMed
58. Dev Cell. 2020 May 4;53(3):316-329.e5 - PubMed

Publication Types

• Journal Article

Grant support

• R01 HL046154/HL/NHLBI NIH HHS/United States
• R37 HL046154/HL/NHLBI NIH HHS/United States