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Kawano H, Kawamura K, Kanda M, et al. Histopathological changes of myocytes in restrictive cardiomyopathy. Med Mol Morphol. 2021;54(3):289-295doi: 10.1007/s00795-021-00293-7.
Kawano, H., Kawamura, K., Kanda, M., Ishijima, M., Abe, K., Hayashi, T., Matsumoto, Y., Kimura, A., & Maemura, K. (2021). Histopathological changes of myocytes in restrictive cardiomyopathy. Medical molecular morphology, 54(3), 289-295. https://doi.org/10.1007/s00795-021-00293-7
Kawano, Hiroaki, et al. "Histopathological changes of myocytes in restrictive cardiomyopathy." Medical molecular morphology vol. 54,3 (2021): 289-295. doi: https://doi.org/10.1007/s00795-021-00293-7
Kawano H, Kawamura K, Kanda M, Ishijima M, Abe K, Hayashi T, Matsumoto Y, Kimura A, Maemura K. Histopathological changes of myocytes in restrictive cardiomyopathy. Med Mol Morphol. 2021 Sep;54(3):289-295. doi: 10.1007/s00795-021-00293-7. Epub 2021 May 31. PMID: 34057638.
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Med Mol Morphol. 2021 Sep;54(3):289-295. doi: 10.1007/s00795-021-00293-7. Epub 2021 May 31.

Histopathological changes of myocytes in restrictive cardiomyopathy.

Medical molecular morphology

Hiroaki Kawano, Koichi Kawamura, Munetake Kanda, Mitsuaki Ishijima, Kuniko Abe, Tomayoshi Hayashi, Yuji Matsumoto, Akinori Kimura, Koji Maemura

Affiliations

  1. Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan. [email protected].
  2. Faculty of Science and Engineering, Waseda University, Tokyo, Japan.
  3. Department of Cardiology, Juzenkai Hospital, Nagasaki, Japan.
  4. Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.
  5. Department of Pathology, Japanese Red Cross Nagasaki Genbaku Hospital, Nagasaki, Japan.
  6. Department of Pathology, Shimabara Prefectural Hospital, Shimabara, Japan.
  7. Department of Cardiology, Japanese Red Cross Nagasaki Genbaku Hospital, Nagasaki, Japan.
  8. Department of Molecular Pathogenesis, Medical Research Institute Tokyo Medical and Dental University, Tokyo, Japan.

PMID: 34057638 DOI: 10.1007/s00795-021-00293-7

Abstract

Restrictive cardiomyopathy (RCM) is a rare primary myocardial disease, and its pathological features are yet to be determined. Restrictive cardiomyopathy with MHY7 mutation was diagnosed in a 65-year-old Japanese woman. Electron microscopy of a myocardial biopsy revealed electron-dense materials resulting from focal myocyte degeneration and necrosis as well as tubular structures and pseudo-inclusion bodies in some nuclei. These features may be associated with the pathogenesis of RCM.

© 2021. The Japanese Society for Clinical Molecular Morphology.

Keywords: Biopsy; Myocardial necrosis; Pathology

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