Display options
Cite
Haffner D, Grund A, Leifheit-Nestler M. Renal effects of growth hormone in health and in kidney disease. Pediatr Nephrol. 2021;36(8):2511-2530doi: 10.1007/s00467-021-05097-6.
Haffner, D., Grund, A., & Leifheit-Nestler, M. (2021). Renal effects of growth hormone in health and in kidney disease. Pediatric nephrology (Berlin, Germany), 36(8), 2511-2530. https://doi.org/10.1007/s00467-021-05097-6
Haffner, Dieter, et al. "Renal effects of growth hormone in health and in kidney disease." Pediatric nephrology (Berlin, Germany) vol. 36,8 (2021): 2511-2530. doi: https://doi.org/10.1007/s00467-021-05097-6
Haffner D, Grund A, Leifheit-Nestler M. Renal effects of growth hormone in health and in kidney disease. Pediatr Nephrol. 2021 Aug;36(8):2511-2530. doi: 10.1007/s00467-021-05097-6. Epub 2021 Jun 18. PMID: 34143299; PMCID: PMC8260426.
Copy Download .nbib Format: NLM
Share it on

Pediatr Nephrol. 2021 Aug;36(8):2511-2530. doi: 10.1007/s00467-021-05097-6. Epub 2021 Jun 18.

Renal effects of growth hormone in health and in kidney disease.

Pediatric nephrology (Berlin, Germany)

Dieter Haffner, Andrea Grund, Maren Leifheit-Nestler

Affiliations

  1. Department of Pediatric Kidney, Liver and Metabolic Diseases, Pediatric Research Center, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany. [email protected].
  2. Pediatric Research Center, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany. [email protected].
  3. Department of Pediatric Kidney, Liver and Metabolic Diseases, Pediatric Research Center, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
  4. Pediatric Research Center, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.

PMID: 34143299 PMCID: PMC8260426 DOI: 10.1007/s00467-021-05097-6

Abstract

Growth hormone (GH) and its mediator insulin-like growth factor-1 (IGF-1) have manifold effects on the kidneys. GH and IGF receptors are abundantly expressed in the kidney, including the glomerular and tubular cells. GH can act either directly on the kidneys or via circulating or paracrine-synthesized IGF-1. The GH/IGF-1 system regulates glomerular hemodynamics, renal gluconeogenesis, tubular sodium and water, phosphate, and calcium handling, as well as renal synthesis of 1,25 (OH)

Keywords: Children; Chronic kidney disease; Diabetic nephropathy; Growth hormone; Hypertrophy; IGF-1; Klotho; Nephrotic syndrome

References

  1. J Clin Invest. 1989 Jan;83(1):326-30 - PubMed
  2. J Am Soc Nephrol. 1996 May;7(5):710-20 - PubMed
  3. Kidney Int. 1997 Sep;52(3):802-10 - PubMed
  4. Endocrinology. 1995 Apr;136(4):1565-71 - PubMed
  5. Am J Med Sci. 1969 Jan;257(1):1-8 - PubMed
  6. J Steroid Biochem Mol Biol. 2017 Sep;172:55-61 - PubMed
  7. Am J Kidney Dis. 1998 Dec;32(6):1000-10 - PubMed
  8. Endocrinology. 1992 Jun;130(6):3237-45 - PubMed
  9. Pediatrics. 1998 Dec;102(6):1407-14 - PubMed
  10. J Clin Endocrinol Metab. 2007 Mar;92(3):902-10 - PubMed
  11. Mol Endocrinol. 1987 Mar;1(3):243-8 - PubMed
  12. J Clin Endocrinol Metab. 1990 Feb;70(2):519-27 - PubMed
  13. Front Physiol. 2020 Jun 26;11:725 - PubMed
  14. Am J Physiol. 1990 Nov;259(5 Pt 2):F747-51 - PubMed
  15. J Clin Invest. 1996 Jul 1;98(1):116-24 - PubMed
  16. Mol Cell Endocrinol. 1997 Sep 19;132(1-2):81-91 - PubMed
  17. J Intern Med. 2012 Jul;272(1):93-7 - PubMed
  18. Endocr Rev. 1991 Aug;12(3):189-207 - PubMed
  19. Pflugers Arch. 1998 Dec;437(1):149-54 - PubMed
  20. Am J Physiol. 1990 Sep;259(3 Pt 2):F474-9 - PubMed
  21. Front Med (Lausanne). 2017 Jul 12;4:102 - PubMed
  22. Nephrol Dial Transplant. 1999 Sep;14(9):2072-4 - PubMed
  23. Quant Imaging Med Surg. 2021 Jan;11(1):410-414 - PubMed
  24. Endocrinology. 1993 Jan;132(1):133-8 - PubMed
  25. Am J Kidney Dis. 1993 Feb;21(2):145-51 - PubMed
  26. Eur J Endocrinol. 2016 Oct;175(4):325-33 - PubMed
  27. Am J Physiol. 1992 May;262(5 Pt 2):F878-84 - PubMed
  28. Clin Endocrinol (Oxf). 1994 Mar;40(3):383-91 - PubMed
  29. J Clin Endocrinol Metab. 1986 Apr;62(4):712-6 - PubMed
  30. Am J Nephrol. 2020;51(7):520-526 - PubMed
  31. Am J Physiol. 1989 Nov;257(5 Pt 1):E751-6 - PubMed
  32. Pediatr Nephrol. 2016 Sep;31(9):1421-35 - PubMed
  33. Am J Physiol. 1993 May;264(5 Pt 2):F917-22 - PubMed
  34. Endocrinology. 1992 Dec;131(6):3061-6 - PubMed
  35. Front Endocrinol (Lausanne). 2018 May 28;9:267 - PubMed
  36. Horm Res. 1998;49(2):91-7 - PubMed
  37. J Biol Chem. 2019 Nov 1;294(44):16109-16122 - PubMed
  38. Pediatr Nephrol. 2013 Jan;28(1):129-33 - PubMed
  39. Acta Endocrinol (Copenh). 1993 Aug;129(2):151-7 - PubMed
  40. Horm Res. 2006;65 Suppl 3:153-9 - PubMed
  41. Nat Rev Nephrol. 2019 Sep;15(9):577-589 - PubMed
  42. J Clin Endocrinol Metab. 1994 Jan;78(1):156-64 - PubMed
  43. Pediatr Nephrol. 1992 Jul;6(4):394-8 - PubMed
  44. Growth Horm IGF Res. 2003 Apr-Jun;13(2-3):55-74 - PubMed
  45. Pharmacol Rep. 2007 Sep-Oct;59(5):500-16 - PubMed
  46. Eur J Endocrinol. 1998 Oct;139(4):454-60 - PubMed
  47. J Pediatr. 1993 Jan;122(1):37-45 - PubMed
  48. Nephron. 1990;55(1):63-8 - PubMed
  49. J Mol Endocrinol. 2018 Jul;61(1):T11-T28 - PubMed
  50. J Clin Endocrinol Metab. 2005 Jul;90(7):3989-94 - PubMed
  51. Kidney Int. 2005 Nov;68(5):2019-28 - PubMed
  52. Pediatr Nephrol. 2005 Mar;20(3):313-8 - PubMed
  53. J Clin Neurosci. 2020 Jan;71:26-31 - PubMed
  54. Nephrol Dial Transplant. 2020 Nov 28;: - PubMed
  55. J Lab Clin Med. 1995 Nov;126(5):428-34 - PubMed
  56. Science. 1957 May 3;125(3253):884-5 - PubMed
  57. Endocrinology. 1995 Feb;136(2):660-7 - PubMed
  58. J Am Soc Nephrol. 2007 Jun;18(6):1652-61 - PubMed
  59. J Cell Biochem. 2015 Sep;116(9):1947-56 - PubMed
  60. J Clin Invest. 1990 Aug;86(2):507-15 - PubMed
  61. Clin Endocrinol (Oxf). 1994 Mar;40(3):393-400 - PubMed
  62. Pediatr Res. 1992 Apr;31(4 Pt 1):406-10 - PubMed
  63. Clin Endocrinol (Oxf). 1995 Mar;42(3):249-54 - PubMed
  64. Mol Endocrinol. 1990 Sep;4(9):1386-98 - PubMed
  65. Eur J Clin Invest. 1992 Mar;22(3):204-9 - PubMed
  66. Endocrinology. 1997 May;138(5):1988-94 - PubMed
  67. J Clin Endocrinol Metab. 2011 Dec;96(12):E2097-105 - PubMed
  68. Clin Nephrol. 2001 Jul;56(1):75-7 - PubMed
  69. J Clin Invest. 1991 Apr;87(4):1200-6 - PubMed
  70. Rev Endocr Metab Disord. 2021 Mar;22(1):101-108 - PubMed
  71. Growth Horm IGF Res. 1998 Apr;8(2):151-7 - PubMed
  72. Endocr Pract. 2014 May;20(5):e86-90 - PubMed
  73. Adv Exp Med Biol. 2017;1033:3-12 - PubMed
  74. Endocrinol Metab Clin North Am. 2012 Jun;41(2):351-74, vii - PubMed
  75. Endocrinology. 2007 May;148(5):2045-55 - PubMed
  76. J Clin Endocrinol Metab. 1993 Feb;76(2):309-17 - PubMed
  77. J Am Soc Nephrol. 1992 Mar;2(9):1417-22 - PubMed
  78. Kidney Int. 2003 Aug;64(2):421-30 - PubMed
  79. Clin Endocrinol (Oxf). 2000 Feb;52(2):181-6 - PubMed
  80. Am J Physiol. 1999 Apr;276(4):R929-34 - PubMed
  81. Nephrol Dial Transplant. 1999 Aug;14(8):1853-60 - PubMed
  82. Eur J Endocrinol. 2018 Apr;178(4):365-375 - PubMed
  83. Lab Invest. 2001 Sep;81(9):1185-90 - PubMed
  84. Endocrinology. 1992 May;130(5):2697-702 - PubMed
  85. J Am Soc Nephrol. 1997 Mar;8(3):436-44 - PubMed
  86. N Engl J Med. 1972 Oct 19;287(16):795-9 - PubMed
  87. J Biol Chem. 2010 Oct 8;285(41):31148-56 - PubMed
  88. Eur J Clin Invest. 1981 Dec;11(6):487-90 - PubMed
  89. J Clin Endocrinol Metab. 1992 Sep;75(3):962-8 - PubMed
  90. Kidney Int. 1994 Feb;45(2):598-604 - PubMed
  91. J Clin Endocrinol Metab. 2012 Jun;97(6):2124-33 - PubMed
  92. J Clin Invest. 1993 May;91(5):2281-7 - PubMed
  93. Endocrinology. 2008 Jul;149(7):3294-305 - PubMed
  94. Am J Nephrol. 1988;8(3):249-54 - PubMed
  95. J Biol Chem. 1989 Jun 15;264(17):9905-10 - PubMed
  96. J Clin Invest. 1991 Aug;88(2):368-74 - PubMed
  97. J Clin Invest. 2004 Jan;113(1):96-105 - PubMed
  98. Pediatr Nephrol. 2017 May;32(5):753-765 - PubMed
  99. J Am Soc Nephrol. 2000 Aug;11(8):1419-1425 - PubMed
  100. Diabetologia. 1989 Apr;32(4):261-5 - PubMed
  101. Ann Intern Med. 2010 May 4;152(9):568-77 - PubMed
  102. Eur J Endocrinol. 2010 Jun;162(6):1035-42 - PubMed
  103. Proc Natl Acad Sci U S A. 1984 Feb;81(3):935-9 - PubMed
  104. Kidney Dis (Basel). 2020 Nov;6(6):395-406 - PubMed
  105. Lab Invest. 1991 Nov;65(5):601-5 - PubMed
  106. J Am Soc Nephrol. 2001 Jul;12(7):1342-1349 - PubMed
  107. Am J Pathol. 1988 Jun;131(3):398-403 - PubMed
  108. J Clin Endocrinol Metab. 2011 Jul;96(7):2127-35 - PubMed
  109. Cell. 1993 Oct 8;75(1):59-72 - PubMed
  110. Endocrinology. 2000 Jan;141(1):163-8 - PubMed
  111. J Clin Endocrinol Metab. 1998 May;83(5):1654-61 - PubMed
  112. Pediatr Nephrol. 1995 Aug;9(4):458-63 - PubMed
  113. N Engl J Med. 1991 May 23;324(21):1483-8 - PubMed
  114. Eur J Endocrinol. 1997 Jan;136(1):45-51 - PubMed
  115. N Engl J Med. 1987 Mar 5;316(10):575-80 - PubMed
  116. Ann Endocrinol (Paris). 2011 Dec;72(6):485-95 - PubMed
  117. Pediatr Nephrol. 1992 Sep;6(5):483-9 - PubMed
  118. Adv Nephrol Necker Hosp. 1991;20:91-108 - PubMed
  119. J Am Soc Nephrol. 1995 Nov;6(5):1511-8 - PubMed
  120. Pediatr Nephrol. 1994 Dec;8(6):684-8 - PubMed
  121. Lancet. 1989 Jun 3;1(8649):1221-5 - PubMed
  122. J Clin Invest. 1962 Jun;41:1230-5 - PubMed
  123. Clin Endocrinol (Oxf). 2015 Oct;83(4):593-5 - PubMed
  124. Calcif Tissue Int. 2013 Feb;92(2):77-98 - PubMed
  125. J Endocrinol Invest. 1996 Jul-Aug;19(7):433-40 - PubMed
  126. J Biol Chem. 1995 Oct 27;270(43):25461-7 - PubMed
  127. Endocrinol Metab Clin North Am. 2020 Sep;49(3):475-486 - PubMed
  128. Pediatr Res. 1996 Jun;39(6):992-8 - PubMed
  129. Pediatr Nephrol. 1991 Jul;5(4):545-7 - PubMed
  130. Annu Rev Physiol. 2008;70:257-71 - PubMed
  131. Am J Physiol. 1997 Feb;272(2 Pt 2):F257-9 - PubMed
  132. Am J Physiol Endocrinol Metab. 2001 Dec;281(6):E1326-32 - PubMed
  133. J Endocrinol. 1994 Sep;142(3):453-62 - PubMed
  134. J Clin Endocrinol Metab. 2000 Apr;85(4):1686-94 - PubMed
  135. Acta Endocrinol (Copenh). 1964 May;46:80-8 - PubMed
  136. Diabetes. 2005 Jun;54(6):1626-34 - PubMed
  137. J Clin Endocrinol Metab. 1997 Aug;82(8):2423-8 - PubMed
  138. Endocr Rev. 2011 Jun;32(3):356-86 - PubMed
  139. Pediatr Nephrol. 1991 Jul;5(4):509-12 - PubMed
  140. N Engl J Med. 1996 Oct 31;335(18):1363-7 - PubMed
  141. Am J Physiol. 1998 Jan;274(1):F120-8 - PubMed
  142. Cochrane Database Syst Rev. 2012 Feb 15;(2):CD003264 - PubMed
  143. J Clin Endocrinol Metab. 1998 Jan;83(1):81-7 - PubMed
  144. Physiol Rep. 2016 Mar;4(5): - PubMed
  145. J Endocrinol. 2013 Nov 01;219(2):R37-57 - PubMed
  146. Mol Endocrinol. 2009 Dec;23(12):1948-62 - PubMed
  147. J Clin Endocrinol Metab. 2013 Aug;98(8):3402-10 - PubMed
  148. Clin Endocrinol (Oxf). 2001 Dec;55(6):741-8 - PubMed
  149. PLoS One. 2019 May 16;14(5):e0216927 - PubMed
  150. Endocr Rev. 1995 Feb;16(1):63-86 - PubMed
  151. Pediatr Nephrol. 1991 Jul;5(4):454-60 - PubMed
  152. BMC Nephrol. 2018 Nov 15;19(1):327 - PubMed
  153. Diabetes. 1998 Aug;47(8):1341-6 - PubMed
  154. Am J Physiol. 1989 Oct;257(4 Pt 1):C612-20 - PubMed
  155. Kidney Int. 2007 Nov;72(10):1262-72 - PubMed
  156. Kidney Int. 2007 Jan;71(2):116-25 - PubMed
  157. J Clin Endocrinol Metab. 2020 Aug 1;105(8): - PubMed
  158. J Clin Endocrinol Metab. 1996 Mar;81(3):1123-8 - PubMed
  159. Kidney Int. 2008 Dec;74(11):1434-43 - PubMed
  160. Pediatr Nephrol. 1997 Jun;11(3):280-4 - PubMed
  161. Clin Endocrinol (Oxf). 2019 Dec;91(6):892-898 - PubMed
  162. J Clin Endocrinol Metab. 1996 Sep;81(9):3352-9 - PubMed
  163. Acta Endocrinol (Copenh). 1978 Dec;89(4):796-800 - PubMed
  164. Kidney Int. 1991 Oct;40(4):792-807 - PubMed
  165. J Clin Invest. 1964 Aug;43:1608-12 - PubMed
  166. Endocr Rev. 1996 Oct;17(5):423-80 - PubMed
  167. Proc Natl Acad Sci U S A. 1992 Dec 15;89(24):11876-80 - PubMed
  168. Endocr Rev. 2014 Apr;35(2):234-81 - PubMed
  169. Clin Sci (Lond). 2000 Jul;99(1):47-56 - PubMed
  170. Life Sci. 2020 Jul 15;253:117581 - PubMed
  171. Clin Nephrol. 1989 Dec;32(6):266-9 - PubMed
  172. Pediatr Res. 1989 Sep;26(3):204-7 - PubMed
  173. J Endocrinol Invest. 1988 Sep;11(8):599-602 - PubMed
  174. Endocrinology. 1992 Jan;130(1):249-56 - PubMed
  175. Vitam Horm. 2016;101:85-118 - PubMed
  176. Annu Rev Nutr. 1999;19:437-61 - PubMed
  177. Am J Physiol. 1991 Jun;260(6 Pt 2):R1036-42 - PubMed
  178. Pediatr Nephrol. 2015 Dec;30(12):2145-51 - PubMed
  179. PLoS One. 2014 Sep 08;9(9):e107174 - PubMed
  180. Ren Fail. 2014 May;36(4):508-13 - PubMed
  181. J Clin Invest. 1954 Jul;33(7):989-94 - PubMed
  182. Pediatr Nephrol. 1996 Jun;10(3):355-8 - PubMed
  183. Cell Physiol Biochem. 2011;27(6):691-702 - PubMed
  184. Am J Kidney Dis. 2015 Feb;65(2):327-36 - PubMed
  185. J Exp Med. 1991 May 1;173(5):1287-90 - PubMed
  186. Diabetes. 1999 Feb;48(2):377-82 - PubMed
  187. Clin J Am Soc Nephrol. 2020 Dec 31;16(1):162-176 - PubMed
  188. Am J Pathol. 1990 Sep;137(3):541-52 - PubMed
  189. J Clin Invest. 1996 Feb 15;97(4):1064-75 - PubMed
  190. Rev Endocr Metab Disord. 2006 Dec;7(4):225-35 - PubMed
  191. Mol Cell Endocrinol. 2014 Aug 25;394(1-2):88-98 - PubMed
  192. J Pediatr. 1996 Feb;128(2):177-83 - PubMed
  193. J Clin Invest. 2001 Aug;108(3):467-75 - PubMed
  194. Pediatr Res. 1998 Apr;43(4 Pt 1):484-8 - PubMed
  195. Kidney Int. 1994 Jul;46(1):201-7 - PubMed
  196. Microvasc Res. 2009 Sep;78(2):246-52 - PubMed
  197. JAMA. 1991 Feb 20;265(7):888-92 - PubMed
  198. J Clin Endocrinol Metab. 1996 Jan;81(1):22-31 - PubMed
  199. Growth Horm IGF Res. 1998 Feb;8(1):39-45 - PubMed
  200. J Intern Med. 1997 Feb;241(2):143-50 - PubMed
  201. N Engl J Med. 1991 Jun 6;324(23):1626-32 - PubMed
  202. Growth Horm IGF Res. 2005 Jun;15(3):207-14 - PubMed
  203. Diabetes Nutr Metab. 1999 Aug;12(4):271-6 - PubMed
  204. Am J Kidney Dis. 1999 Jun;33(6):1158-63 - PubMed
  205. N Engl J Med. 1989 Oct 12;321(15):989-95 - PubMed
  206. Growth Horm IGF Res. 2004 Dec;14(6):418-30 - PubMed
  207. Curr Diabetes Rev. 2011 Jan;7(1):50-5 - PubMed
  208. Lab Invest. 1993 Jan;68(1):62-70 - PubMed
  209. Kidney Int. 1989 Mar;35(3):865-70 - PubMed
  210. Acta Endocrinol (Copenh). 1989 Jul;121(1):101-6 - PubMed
  211. Diabet Med. 1990 May;7(4):304-9 - PubMed
  212. Am J Physiol Endocrinol Metab. 2014 Aug 1;307(3):E326-34 - PubMed
  213. Kidney Int Rep. 2020 Aug 31;5(11):1993-2001 - PubMed
  214. Endocrinology. 2007 Jan;148(1):441-51 - PubMed
  215. Nat Rev Nephrol. 2019 Aug;15(8):482-500 - PubMed
  216. Metabolism. 1996 Aug;45(8 Suppl 1):91-5 - PubMed
  217. J Clin Endocrinol Metab. 1993 Jul;77(1):273-80 - PubMed
  218. J Clin Endocrinol Metab. 2008 Mar;93(3):710-4 - PubMed
  219. Front Med (Lausanne). 2021 Jan 15;7:563020 - PubMed
  220. Front Endocrinol (Lausanne). 2020 Nov 30;11:577173 - PubMed
  221. J Am Soc Nephrol. 1995 Apr;5(10):1782-91 - PubMed
  222. Front Endocrinol (Lausanne). 2018 Feb 13;9:35 - PubMed
  223. Mol Endocrinol. 2011 Jul;25(7):1223-30 - PubMed

Publication Types