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Cosco D, Bruno F, Castelli G, et al. Meglumine Antimoniate-Loaded Aqueous-Core PLA Nanocapsules: Old Drug, New Formulation against Leishmania-Related Diseases. Macromol Biosci. 2021;21(7):e2100046doi: 10.1002/mabi.202100046.
Cosco, D., Bruno, F., Castelli, G., Puleio, R., Bonacci, S., Procopio, A., Britti, D., Fresta, M., Vitale, F., & Paolino, D. (2021). Meglumine Antimoniate-Loaded Aqueous-Core PLA Nanocapsules: Old Drug, New Formulation against Leishmania-Related Diseases. Macromolecular bioscience, 21(7), e2100046. https://doi.org/10.1002/mabi.202100046
Cosco, Donato, et al. "Meglumine Antimoniate-Loaded Aqueous-Core PLA Nanocapsules: Old Drug, New Formulation against Leishmania-Related Diseases." Macromolecular bioscience vol. 21,7 (2021): e2100046. doi: https://doi.org/10.1002/mabi.202100046
Cosco D, Bruno F, Castelli G, Puleio R, Bonacci S, Procopio A, Britti D, Fresta M, Vitale F, Paolino D. Meglumine Antimoniate-Loaded Aqueous-Core PLA Nanocapsules: Old Drug, New Formulation against Leishmania-Related Diseases. Macromol Biosci. 2021 Jul;21(7):e2100046. doi: 10.1002/mabi.202100046. Epub 2021 Jun 12. PMID: 34117834.
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Macromol Biosci. 2021 Jul;21(7):e2100046. doi: 10.1002/mabi.202100046. Epub 2021 Jun 12.

Meglumine Antimoniate-Loaded Aqueous-Core PLA Nanocapsules: Old Drug, New Formulation against Leishmania-Related Diseases.

Macromolecular bioscience

Donato Cosco, Federica Bruno, Germano Castelli, Roberto Puleio, Sonia Bonacci, Antonio Procopio, Domenico Britti, Massimo Fresta, Fabrizio Vitale, Donatella Paolino

Affiliations

  1. Department of Health Sciences, University "Magna Graecia" of Catanzaro, Campus Universitario "S. Venuta,", Catanzaro, I-88100, Italy.
  2. Centro di Referenza Nazionale per le Leishmaniosi, Istituto Zooprofilattico Sperimentale della Sicilia A. Mirri, Via G. Marinuzzi 3, Palermo, 90129, Italy.
  3. Laboratorio Istopatologia e Immunoistochimica, Istituto Zooprofilattico Sperimentale della Sicilia A. Mirri, Via G. Marinuzzi 3, Palermo, 90129, Italy.
  4. Department of Experimental and Clinical Medicine, University "Magna Graecia" of Catanzaro, Campus Universitario "S. Venuta,", Catanzaro, I-88100, Italy.

PMID: 34117834 DOI: 10.1002/mabi.202100046

Abstract

Leishmaniasis is a human and animal disease endemic in tropical and subtropical areas treated by means of pentavalent antimony as first-line approach. Unfortunately, the formulations available on the market are characterized by significant side effects and a total remission of the disease is difficult to be obtained. The aim of this investigation is to describe the development and characterization of aqueous-core poly-l-lactide (PLA) nanocapsules containing glucantime (meglumine antimoniate, MA) with the aim of increasing the pharmacological efficacy of the active compound. The polymeric systems characterized by a mean diameter of ≈300 nm exert a great interaction with murine macrophages. MA-loaded PLA nanocapsules show a great antileishmanial activity on mice infected with Leishmania infantum with respect to the free drug, favoring a decrease of the administration times. The biodistribution profiles demonstrate a lower renal accumulation of MA after its nanoencapsulation and a significant increase of its plasmatic half-life. The parasite load evaluated by immunohistochemistry shows a significant decrease in liver, spleen, and kidneys when mice are treated with MA-loaded PLA nanocapsules especially after 45 days. The obtained results demonstrate the potential application of MA-loaded PLA nanocapsules as novel nanomedicine for the treatment of leishmaniasis.

© 2021 Wiley-VCH GmbH.

Keywords: PLA; glucantime; leishmaniasis; meglumine antimoniate; nanocapsules

References

  1. a) S. G. Carvalho, V. H. S. Araujo, A. M. dos Santos, J. L. Duarte, A. L. P. Silvestre, B. Fonseca-Santos, J. C. O. Villanova, M. P. D. Gremião, M. Chorilli, Int. J. Pharm. 2020, 580, 119214; - PubMed
  2. b) A. Schroeder, D. A. Heller, M. M. Winslow, J. E. Dahlman, G. W. Pratt, R. Langer, T. Jacks, D. G. Anderson, Nat. Rev. Cancer 2011, 12, 39; - PubMed
  3. c) A. M. Sofias, F. Combes, S. Koschmieder, G. Storm, T. Lammers, Drug Discovery Today 2021, https://doi.org/10.1016/j.drudis.2021.02.017. - PubMed
  4. N. Kamaly, B. Yameen, J. Wu, O. C. Farokhzad, Chem. Rev. 2016, 116, 2602. - PubMed
  5. a) Y. Barenholz, J. Controlled Release 2012, 160, 117; - PubMed
  6. b) C. M. Dawidczyk, C. Kim, J. H. Park, L. M. Russell, K. H. Lee, M. G. Pomper, P. C. Searson, J. Controlled Release 2014, 187, 133; - PubMed
  7. c) N. Bertrand, J. Wu, X. Xu, N. Kamaly, O. C. Farokhzad, Adv. Drug Delivery Rev. 2014, 66, 2. - PubMed
  8. A. Wicki, D. Witzigmann, V. Balasubramanian, J. Huwyler, J. Controlled Release 2015, 200, 138. - PubMed
  9. a) E. Miele, G. P. Spinelli, E. Miele, F. Tomao, S. Tomao, Int. J. Nanomed. 2009, 4, 99; - PubMed
  10. b) F. Molavi, M. Barzegar-Jalali, H. Hamishehkar, J. Controlled Release 2020, 320, 265; - PubMed
  11. c) A. Gagliardi, E. Giuliano, E. Venkateswararao, M. Fresta, S. Bulotta, V. Awasthi, D. Cosco, Front. Pharmacol. 2021, 12, 601626. - PubMed
  12. a) D. Cosco, L. Marzio, C. Marianecci, E. Trapasso, D. Paolino, C. Celia, M. Carafa, M. Fresta, Curr. Med. Chem. 2014, 21, 4132; - PubMed
  13. b) J. Kreuter, Pharmaceutics 2015, 7, 3. - PubMed
  14. E. Palma, A. Pasqua, A. Gagliardi, D. Britti, M. Fresta, D. Cosco, Materials 2018, 11, E1167. - PubMed
  15. F. Frézard, C. Demicheli, R. Ribeiro, Molecules 2009, 14, 2317. - PubMed
  16. F. J. D. de Moura, P. P. Leal, R. de Souza Furtado, M. I. Muniz-Junqueira, J. P. R. Veiga, Toxicology 2008, 243, 66. - PubMed
  17. R. R. Ribeiro, E. P. Moura, V. M. Pimentel, W. M. Sampaio, S. M. Silva, D. A. Schettini, C. F. Alves, F. A. Melo, W. L. Tafuri, C. Demicheli, M. N. Melo, F. Frézard, M. S. M. Michalick, Antimicrob. Agents Chemother. 2008, 52, 2564. - PubMed
  18. S. E. Treiger Borborema, R. A. Schwendener, J. A. Osso Junior, H. F. de Andrade Jr., N. do Nascimento, Int. J. Antimicrob. Agents 2011, 38, 341. - PubMed
  19. F. Frézard, C. Demicheli, Expert Opin. Drug Delivery 2010, 7, 1343. - PubMed
  20. a) F. Frézard, P. S. Martins, A. P. C. O. Bahia, L. Le Moyec, A. L. de Melo, A. M. C. Pimenta, M. Salerno, J. B. B. da Silva, C. Demicheli, Int. J. Pharm. 2008, 347, 102; - PubMed
  21. b) R. R. Ribeiro, W. A. Ferreira, P. S. Martins, R. L. Neto, O. G. Rocha, L. Le Moyec, C. Demicheli, F. Frézard, Biopharm. Drug Dispos. 2010, 31, 109. - PubMed
  22. G. Pujals, J. M. Suñé-Negre, P. Pérez, E. García, M. Portus, J. R. Tico, M. Miñarro, J. Carrió, Parasitol. Res. 2008, 102, 1243. - PubMed
  23. a) A. d. J. Sousa-Batista, C. Cerqueira-Coutinho, F. S. do Carmo, M. d. S. Albernaz, R. Santos-Oliveira, Am. J. Ther. 2019, 26, e12; - PubMed
  24. b) J. Varshosaz, B. Arbabi, N. Pestehchian, S. Saberi, M. Delavari, Int. J. Biol. Macromol. 2018, 107, 212. - PubMed
  25. a) D. Paolino, D. Cosco, M. Celano, S. Moretti, E. Puxeddu, D. Russo, M. Fresta, Nanomedicine 2013, 8, 193; - PubMed
  26. b) D. Cosco, D. Paolino, F. De Angelis, F. Cilurzo, C. Celia, L. Di Marzio, D. Russo, N. Tsapis, E. Fattal, M. Fresta, Eur. J. Pharm. Biopharm. 2015, 89, 30. - PubMed
  27. a) E. Pisani, N. Tsapis, J. Paris, V. Nicolas, L. Cattel, E. Fattal, Langmuir 2006, 22, 4397; - PubMed
  28. b) E. Pisani, E. Fattal, J. Paris, C. Ringard, V. Rosilio, N. Tsapis, J. Colloid Interface Sci. 2008, 326, 66. - PubMed
  29. a) V. Agrahari, P.-A. Burnouf, T. Burnouf, V. Agrahari, Adv. Drug Delivery Rev. 2019, 148, 146; - PubMed
  30. b) R. Cai, C. Chen, Adv. Mater. 2019, 31, 1805740. - PubMed
  31. A. Gagliardi, D. Paolino, M. Iannone, E. Palma, M. Fresta, D. Cosco, Int. J. Nanomed. 2018, 13, 601. - PubMed
  32. A. Gagliardi, S. Bonacci, D. Paolino, C. Celia, A. Procopio, M. Fresta, D. Cosco, Heliyon 2019, 5, e02422. - PubMed
  33. a) B. K. Lee, Y. Yun, K. Park, Adv. Drug Delivery Rev. 2016, 107, 176; - PubMed
  34. b) B. Tyler, D. Gullotti, A. Mangraviti, T. Utsuki, H. Brem, Adv. Drug Delivery Rev. 2016, 107, 163. - PubMed
  35. a) A. A. D'souza, R. Shegokar, Expert Opin. Drug Delivery 2016, 13, 1257; - PubMed
  36. b) F. S. Mozar, E. H. Chowdhury, Curr. Pharm. Des. 2018, 24, 3283. - PubMed
  37. a) A. S. Abu Lila, H. Kiwada, T. Ishida, J. Controlled Release 2013, 172, 38; - PubMed
  38. b) K. Shiraishi, K. Kawano, Y. Maitani, T. Aoshi, K. J. Ishii, Y. Sanada, S. Mochizuki, K. Sakurai, M. Yokoyama, J. Controlled Release 2016, 234, 59. - PubMed
  39. a) F. A. Ikeda-Garcia, R. S. Lopes, P. C. Ciarlini, F. J. Marques, V. M. F. Lima, S. H. V. Perri, M. M. Feitosa, Res. Vet. Sci. 2007, 83, 105; - PubMed
  40. b) P. Bianciardi, C. Brovida, M. Valente, L. Aresu, L. Cavicchioli, C. Vischer, L. Giroud, M. Castagnaro, Toxicol. Pathol. 2009, 37, 770. - PubMed
  41. S. Sundar, A. Singh, Parasitology 2018, 145, 481. - PubMed
  42. H. S. Sarwar, S. Ashraf, S. Akhtar, M. F. Sohail, S. Z. Hussain, M. Rafay, M. Yasinzai, I. Hussain, G. Shahnaz, Nanomedicine 2018, 13, 25. - PubMed
  43. D. Cosco, R. Mare, D. Paolino, M. C. Salvatici, F. Cilurzo, M. Fresta, Int. J. Biol. Macromol. 2019, 132, 550. - PubMed
  44. D. Paolino, D. Cosco, F. Cilurzo, E. Trapasso, V. M. Morittu, C. Celia, M. Fresta, J. Controlled Release 2012, 162, 143. - PubMed
  45. G. Castelli, F. Bruno, F. Vitale, M. Roberti, C. Colomba, E. Giacomini, L. Guidotti, A. Cascio, M. Tolomeo, Exp. Parasitol. 2016, 166, 1. - PubMed
  46. C. Maia, N. Rolão, M. Nunes, L. Gonçalves, L. Campino, Acta Trop. 2007, 103, 150. - PubMed
  47. a) S. De Souza Leao, T. Lang, E. Prina, R. Hellio, J. C. Antoine, J. Cell Sci. 1995, 108, 3219; - PubMed
  48. b) N. Azzouz, C. S. de Macedo, M. A. J. Ferguson, T. K. Smith, R. T. Schwarz, Mol. Biochem. Parasitol. 2005, 142, 12. - PubMed
  49. D. Mendes Costa, P. Cecílio, N. Santarém, A. Cordeiro-da-Silva, J. Tavares, Sci. Rep. 2019, 9, 18989. - PubMed
  50. G. Castelli, A. Galante, V. Lo Verde, A. Migliazzo, S. Reale, T. Lupo, M. Piazza, F. Vitale, F. Bruno, J. Parasitol. 2014, 100, 228. - PubMed
  51. S. Reale, A. Torina, M. Sole, S. Calderone, M. Piazza, T. Lupo, L. Manna, A. E. Gravino, V. Currò, F. Vitale, Ann. N. Y. Acad. Sci. 2008, 1149, 334. - PubMed
  52. W. L. Tafuri, R. d. L. Santos, R. M. E. Arantes, R. Gonçalves, M. N. de Melo, M. S. M. Michalick, W. L. Tafuri, J. Immunol. Methods 2004, 292, 17. - PubMed

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