Display options
Cite
Grothe MJ, Labrador-Espinosa MA, Jesús S, et al. In vivo cholinergic basal forebrain degeneration and cognition in Parkinson's disease: Imaging results from the COPPADIS study. Parkinsonism Relat Disord. 2021;88:68-75doi: 10.1016/j.parkreldis.2021.05.027.
Grothe, M. J., Labrador-Espinosa, M. A., Jesús, S., Macías-García, D., Adarmes-Gómez, A., Carrillo, F., Camacho, E. I., Franco-Rosado, P., Lora, F. R., Martín-Rodríguez, J. F., Barberá, M. A., Pastor, P., Arroyo, S. E., Vila, B. S., Foraster, A. C., Martínez, J. R., Padilla, F. C., Morlans, M. P., Aramburu, I. G., Ceberio, J. I., Vara, J. H., de Fábregues-Boixar, O., de Deus Fonticoba, T., Pascual-Sedano, B., Kulisevsky, J., Martínez-Martín, P., Santos-García, D., & Mir, P. (2021). In vivo cholinergic basal forebrain degeneration and cognition in Parkinson's disease: Imaging results from the COPPADIS study. Parkinsonism & related disorders, 8868-75. https://doi.org/10.1016/j.parkreldis.2021.05.027
Grothe, Michel J, et al. "In vivo cholinergic basal forebrain degeneration and cognition in Parkinson's disease: Imaging results from the COPPADIS study." Parkinsonism & related disorders vol. 88 (2021): 68-75. doi: https://doi.org/10.1016/j.parkreldis.2021.05.027
Grothe MJ, Labrador-Espinosa MA, Jesús S, Macías-García D, Adarmes-Gómez A, Carrillo F, Camacho EI, Franco-Rosado P, Lora FR, Martín-Rodríguez JF, Barberá MA, Pastor P, Arroyo SE, Vila BS, Foraster AC, Martínez JR, Padilla FC, Morlans MP, Aramburu IG, Ceberio JI, Vara JH, de Fábregues-Boixar O, de Deus Fonticoba T, Pascual-Sedano B, Kulisevsky J, Martínez-Martín P, Santos-García D, Mir P. In vivo cholinergic basal forebrain degeneration and cognition in Parkinson's disease: Imaging results from the COPPADIS study. Parkinsonism Relat Disord. 2021 Jul;88:68-75. doi: 10.1016/j.parkreldis.2021.05.027. Epub 2021 May 31. PMID: 34144230.
Copy Download .nbib Format: NLM
Share it on

Parkinsonism Relat Disord. 2021 Jul;88:68-75. doi: 10.1016/j.parkreldis.2021.05.027. Epub 2021 May 31.

In vivo cholinergic basal forebrain degeneration and cognition in Parkinson's disease: Imaging results from the COPPADIS study.

Parkinsonism & related disorders

Michel J Grothe, Miguel A Labrador-Espinosa, Silvia Jesús, Daniel Macías-García, Astrid Adarmes-Gómez, Fátima Carrillo, Elena Iglesias Camacho, Pablo Franco-Rosado, Florinda Roldán Lora, Juan Francisco Martín-Rodríguez, Miquel Aguilar Barberá, Pau Pastor, Sonia Escalante Arroyo, Berta Solano Vila, Anna Cots Foraster, Javier Ruiz Martínez, Francisco Carrillo Padilla, Mercedes Pueyo Morlans, Isabel González Aramburu, Jon Infante Ceberio, Jorge Hernández Vara, Oriol de Fábregues-Boixar, Teresa de Deus Fonticoba, Berta Pascual-Sedano, Jaime Kulisevsky, Pablo Martínez-Martín, Diego Santos-García, Pablo Mir

Affiliations

  1. Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain; Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain. Electronic address: [email protected].
  2. Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain; Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.
  3. Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.
  4. Unidad de Radiodiagnóstico, Hospital Universitario Virgen del Rocío, Seville, Spain.
  5. Hospital Universitari Mutua de Terrassa, Terrassa, Barcelona, Spain.
  6. Hospital de Tortosa Verge de la Cinta (HTVC), Tortosa, Tarragona, Spain.
  7. Institut Catalá de la Salud (Girona) - Institut d'Assisténcia Sanitaria (IAS), Spain.
  8. Instituto de Investigación Biodonostia, Hospital Universitario Donostia, San Sebastián, Spain.
  9. Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain.
  10. Unidad de Trastornos del Movimiento, Servicio de Neurología, Hospital Universitario Marqués de Valdecilla, Santander, Spain.
  11. Neurology Department and Neurodegenerative Diseases Research Group. Vall D'Hebron Universitary Campus, Barcelona, Spain.
  12. Complejo Hospitalario Universitario de Ferrol (CHUF), Hospital Arquitecto Marcide, Ferrol, Spain.
  13. Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain; Unidad de Trastornos del Movimiento, Servicio de Neurología, Hospital de Sant Pau, Barcelona, Spain; Faculty of Health Sciences, Universitat Oberta de Catalunya (UOC), Barcelona, Spain.
  14. Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain; Unidad de Trastornos del Movimiento, Servicio de Neurología, Hospital de Sant Pau, Barcelona, Spain.
  15. Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.
  16. Complejo Hospitalario Universitario de A Coruña (CHUAC), A Coruña, Spain.
  17. Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain; Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain. Electronic address: [email protected].

PMID: 34144230 DOI: 10.1016/j.parkreldis.2021.05.027

Abstract

INTRODUCTION: We aimed to assess associations between multimodal neuroimaging measures of cholinergic basal forebrain (CBF) integrity and cognition in Parkinson's disease (PD) without dementia.

METHODS: The study included a total of 180 non-demented PD patients and 45 healthy controls, who underwent structural MRI acquisitions and standardized neurocognitive assessment through the PD-Cognitive Rating Scale (PD-CRS) within the multicentric COPPADIS-2015 study. A subset of 73 patients also had Diffusion Tensor Imaging (DTI) acquisitions. Volumetric and microstructural (mean diffusivity, MD) indices of CBF degeneration were automatically extracted using a stereotactic CBF atlas. For comparison, we also assessed multimodal indices of hippocampal degeneration. Associations between imaging measures and cognitive performance were assessed using linear models.

RESULTS: Compared to controls, CBF volume was not significantly reduced in PD patients as a group. However, across PD patients lower CBF volume was significantly associated with lower global cognition (PD-CRS

CONCLUSIONS: Early cognitive deficits in PD without dementia are more closely related to structural MRI measures of CBF degeneration than hippocampal degeneration. In our multicentric imaging acquisitions, DTI-based diffusion measures in the CBF were inferior to standard volumetric assessments for capturing cognition-relevant changes in non-demented PD.

Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Keywords: DTI; Diffusion; MRI; Nucleus basalis Meynert; Parkinson's disease; Substantia innominata

Publication Types