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Yaqub F, Latief N, Butt H, et al. Alpha lipoic acid priming enhances the hepatoprotective effect of adipose derived stem cells in CCl4 induced hepatic injury in-vitro. Eur J Pharmacol. 2021;906:174201doi: 10.1016/j.ejphar.2021.174201.
Yaqub, F., Latief, N., Butt, H., Naseer, N., & Riazuddin, S. (2021). Alpha lipoic acid priming enhances the hepatoprotective effect of adipose derived stem cells in CCl4 induced hepatic injury in-vitro. European journal of pharmacology, 906174201. https://doi.org/10.1016/j.ejphar.2021.174201
Yaqub, Faiza, et al. "Alpha lipoic acid priming enhances the hepatoprotective effect of adipose derived stem cells in CCl4 induced hepatic injury in-vitro." European journal of pharmacology vol. 906 (2021): 174201. doi: https://doi.org/10.1016/j.ejphar.2021.174201
Yaqub F, Latief N, Butt H, Naseer N, Riazuddin S. Alpha lipoic acid priming enhances the hepatoprotective effect of adipose derived stem cells in CCl4 induced hepatic injury in-vitro. Eur J Pharmacol. 2021 Sep 05;906:174201. doi: 10.1016/j.ejphar.2021.174201. Epub 2021 Jun 09. PMID: 34118221.
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Eur J Pharmacol. 2021 Sep 05;906:174201. doi: 10.1016/j.ejphar.2021.174201. Epub 2021 Jun 09.

Alpha lipoic acid priming enhances the hepatoprotective effect of adipose derived stem cells in CCl4 induced hepatic injury in-vitro.

European journal of pharmacology

Faiza Yaqub, Noreen Latief, Hira Butt, Nadia Naseer, Sheikh Riazuddin

Affiliations

  1. National Centre of Excellence in Molecular Biology, University of Punjab, 87-West Canal Bank Road, Lahore, Pakistan. Electronic address: [email protected].
  2. National Centre of Excellence in Molecular Biology, University of Punjab, 87-West Canal Bank Road, Lahore, Pakistan. Electronic address: [email protected].
  3. National Centre of Excellence in Molecular Biology, University of Punjab, 87-West Canal Bank Road, Lahore, Pakistan. Electronic address: [email protected].
  4. National Centre of Excellence in Molecular Biology, University of Punjab, 87-West Canal Bank Road, Lahore, Pakistan. Electronic address: [email protected].
  5. National Centre of Excellence in Molecular Biology, University of Punjab, 87-West Canal Bank Road, Lahore, Pakistan; Jinnah Burn & Reconstructive Surgery Centre, Lahore, Pakistan. Electronic address: [email protected].

PMID: 34118221 DOI: 10.1016/j.ejphar.2021.174201

Abstract

Mesenchymal stem cells are known to support hepatic defense against liver fibrosis. However, the fibrosis induced oxidative microenvironment affects the proliferative, regenerative, and angiogenic properties of mesenchymal stem cells. Alpha lipoic acid (ALA) is a strong anti-oxidant which has been shown to ameliorate the adverse effects of fibrosis that otherwise can lead to severe liver problems like cirrhosis and liver failure. Here, we studied the protective role of ALA primed adipose derived stem cells (ADSCs) against carbon tetrachloride (CCl

Copyright © 2021 Elsevier B.V. All rights reserved.

Keywords: Adipose derived stem cells; Alpha lipoic acid; CCl(4) induced hepatotoxicity; Primary hepatocytes

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