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Hollingsworth BA, Cassatt DR, DiCarlo AL, et al. Acute Radiation Syndrome and the Microbiome: Impact and Review. Front Pharmacol. 2021;12:643283doi: 10.3389/fphar.2021.643283.
Hollingsworth, B. A., Cassatt, D. R., DiCarlo, A. L., Rios, C. I., Satyamitra, M. M., Winters, T. A., & Taliaferro, L. P. (2021). Acute Radiation Syndrome and the Microbiome: Impact and Review. Frontiers in pharmacology, 12643283. https://doi.org/10.3389/fphar.2021.643283
Hollingsworth, Brynn A, et al. "Acute Radiation Syndrome and the Microbiome: Impact and Review." Frontiers in pharmacology vol. 12 (2021): 643283. doi: https://doi.org/10.3389/fphar.2021.643283
Hollingsworth BA, Cassatt DR, DiCarlo AL, Rios CI, Satyamitra MM, Winters TA, Taliaferro LP. Acute Radiation Syndrome and the Microbiome: Impact and Review. Front Pharmacol. 2021 May 18;12:643283. doi: 10.3389/fphar.2021.643283. eCollection 2021. PMID: 34084131; PMCID: PMC8167050.
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Front Pharmacol. 2021 May 18;12:643283. doi: 10.3389/fphar.2021.643283. eCollection 2021.

Acute Radiation Syndrome and the Microbiome: Impact and Review.

Frontiers in pharmacology

Brynn A Hollingsworth, David R Cassatt, Andrea L DiCarlo, Carmen I Rios, Merriline M Satyamitra, Thomas A Winters, Lanyn P Taliaferro

Affiliations

  1. Radiation and Nuclear Countermeasures Program (RNCP), Division of Allergy, Immunology and Transplantation (DAIT), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Rockville, MD, United States.

PMID: 34084131 PMCID: PMC8167050 DOI: 10.3389/fphar.2021.643283

Abstract

Study of the human microbiota has been a centuries-long endeavor, but since the inception of the National Institutes of Health (NIH) Human Microbiome Project in 2007, research has greatly expanded, including the space involving radiation injury. As acute radiation syndrome (ARS) is multisystemic, the microbiome niches across all areas of the body may be affected. This review highlights advances in radiation research examining the effect of irradiation on the microbiome and its potential use as a target for medical countermeasures or biodosimetry approaches, or as a medical countermeasure itself. The authors also address animal model considerations for designing studies, and the potential to use the microbiome as a biomarker to assess radiation exposure and predict outcome. Recent research has shown that the microbiome holds enormous potential for mitigation of radiation injury, in the context of both radiotherapy and radiological/nuclear public health emergencies. Gaps still exist, but the field is moving forward with much promise.

Copyright © 2021 Hollingsworth, Cassatt, DiCarlo, Rios, Satyamitra, Winters and Taliaferro.

Keywords: acute radiation syndrome; microbiome; radiation; radiation biodosimetry; radiation medical countermeasure

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

References

  1. FEMS Microbiol Lett. 1989 Nov;53(1-2):171-6 - PubMed
  2. Radiat Res. 2013 Jan;179(1):89-100 - PubMed
  3. J Appl Oral Sci. 2011 Oct;19(5):448-54 - PubMed
  4. Gastroenterology. 2019 Sep;157(3):902 - PubMed
  5. Gastroenterol Clin North Am. 2017 Dec;46(4):825-837 - PubMed
  6. Cancer Med. 2020 Jun;9(11):3714-3724 - PubMed
  7. Ocul Surf. 2021 Jan;19:210-217 - PubMed
  8. Clin Ophthalmol. 2020 Oct 09;14:3153-3166 - PubMed
  9. PLoS One. 2013 Dec 18;8(12):e82659 - PubMed
  10. J Clin Med. 2020 Jun 08;9(6): - PubMed
  11. Gastroenterology. 2019 May;156(6):1921-1923.e3 - PubMed
  12. Microbiome. 2018 Jan 30;6(1):20 - PubMed
  13. Nature. 1968 Dec 14;220(5172):1137-9 - PubMed
  14. NPJ Precis Oncol. 2020 Dec 10;4(1):33 - PubMed
  15. Cancers (Basel). 2020 Sep 06;12(9): - PubMed
  16. Wound Repair Regen. 2010 Jan-Feb;18(1):50-8 - PubMed
  17. Support Care Cancer. 2020 Mar;28(3):1069-1075 - PubMed
  18. Ann Am Thorac Soc. 2014 Jan;11(1):108-16 - PubMed
  19. Nat Rev Immunol. 2010 Mar;10(3):159-69 - PubMed
  20. Front Physiol. 2018 Aug 21;9:1168 - PubMed
  21. Bull Cancer. 2020 Jan;107(1):72-83 - PubMed
  22. PLoS One. 2010 May 17;5(5):e10667 - PubMed
  23. Bull Acad Natl Med. 2007 Jun;191(6):971-8; discussion 979 - PubMed
  24. NPJ Breast Cancer. 2017 Mar 31;3:10 - PubMed
  25. Health Phys. 2014 Jan;106(1):21-38 - PubMed
  26. Curr Opin Microbiol. 2011 Feb;14(1):82-91 - PubMed
  27. Oral Dis. 2019 Oct;25(7):1798-1808 - PubMed
  28. Environ Pollut. 2019 Dec;255(Pt 1):113238 - PubMed
  29. South Med J. 2010 Jun;103(6):541-6 - PubMed
  30. Microbiome. 2017 Aug 18;5(1):105 - PubMed
  31. Diagn Microbiol Infect Dis. 1987 May;7(1):1-7 - PubMed
  32. BMC Cancer. 2019 May 23;19(1):488 - PubMed
  33. BMC Microbiol. 2009 Jun 09;9:123 - PubMed
  34. Nat Rev Microbiol. 2011 Apr;9(4):279-90 - PubMed
  35. Immunity. 2012 May 25;36(5):873-84 - PubMed
  36. Radiat Res. 2020 Jul 8;194(1):52-60 - PubMed
  37. World J Gastroenterol. 2015 Aug 7;21(29):8787-803 - PubMed
  38. Radiother Oncol. 2021 Mar;156:1-9 - PubMed
  39. Drug Dev Res. 2014 Feb;75(1):23-8 - PubMed
  40. Nature. 2019 Jan;565(7741):600-605 - PubMed
  41. Science. 2001 Jul 13;293(5528):293-7 - PubMed
  42. Eur Arch Otorhinolaryngol. 2014 Dec;271(12):3195-201 - PubMed
  43. Appl Microbiol. 1974 May;27(5):961-79 - PubMed
  44. Gut. 2020 Mar;69(3):513-522 - PubMed
  45. Ann Am Thorac Soc. 2014 Jan;11 Suppl 1:S66-70 - PubMed
  46. Health Phys. 2018 Jan;114(1):43-57 - PubMed
  47. Eur Urol Focus. 2018 Jan;4(1):128-138 - PubMed
  48. Science. 1999 May 21;284(5418):1308-10 - PubMed
  49. Radiat Res. 2020 Nov 10;194(5):452-464 - PubMed
  50. J Eur Acad Dermatol Venereol. 2016 Dec;30(12):2038-2047 - PubMed
  51. J Extracell Vesicles. 2020 Jul 17;9(1):1793514 - PubMed
  52. PLoS One. 2016 Aug 16;11(8):e0161174 - PubMed
  53. Nutrients. 2019 May 07;11(5): - PubMed
  54. Science. 2011 Oct 14;334(6053):255-8 - PubMed
  55. Cancer Med. 2017 Dec;6(12):2918-2931 - PubMed
  56. Ceska Gynekol. 2018 Winter;83(5):371-379 - PubMed
  57. J Virol. 2016 Apr 29;90(10):4981-4989 - PubMed
  58. Radiat Res. 1981 Dec;88(3):533-41 - PubMed
  59. Health Phys. 2010 Jun;98(6):903-5 - PubMed
  60. Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7503-8 - PubMed
  61. Radiother Oncol. 2020 Feb;143:12-18 - PubMed
  62. Int J Mol Sci. 2017 Jun 09;18(6): - PubMed
  63. Otolaryngol Pol. 2014 Jan-Feb;68(1):1-14 - PubMed
  64. Appl Environ Microbiol. 2019 Oct 30;85(22): - PubMed
  65. Microbiome. 2020 May 20;8(1):69 - PubMed
  66. Nature. 2008 Nov 27;456(7221):507-10 - PubMed
  67. Appl Environ Microbiol. 1999 Nov;65(11):4799-807 - PubMed
  68. Sci Rep. 2020 Jul 21;10(1):12035 - PubMed
  69. Am J Physiol Gastrointest Liver Physiol. 2016 May 1;310(9):G705-15 - PubMed
  70. Dis Model Mech. 2015 Jan;8(1):1-16 - PubMed
  71. Health Phys. 2012 Oct;103(4):383-99 - PubMed
  72. Prog Neuropsychopharmacol Biol Psychiatry. 2021 Mar 2;106:110111 - PubMed
  73. Science. 2020 Oct 30;370(6516): - PubMed
  74. Nutrients. 2011 Jun;3(6):637-82 - PubMed
  75. J Oral Microbiol. 2019 Mar 08;11(1):1586421 - PubMed
  76. Radiat Res. 2019 Apr;191(4):323-334 - PubMed
  77. Radiat Res. 2015 Jun;183(6):643-55 - PubMed
  78. Open Access Maced J Med Sci. 2019 Sep 12;7(18):3034-3038 - PubMed
  79. Clin Microbiol Infect. 2016 Jul;22(7):643.e7-643.e12 - PubMed
  80. Clin Infect Dis. 2011 Feb 15;52(4):e56-93 - PubMed
  81. Semin Immunol. 2013 Nov 30;25(5):370-7 - PubMed
  82. Adv Sci (Weinh). 2019 Aug 29;6(21):1901048 - PubMed
  83. NPJ Biofilms Microbiomes. 2017 Jan 26;3:2 - PubMed
  84. JPEN J Parenter Enteral Nutr. 2017 Nov;41(8):1399-1410 - PubMed
  85. Curr Opin Gastroenterol. 2010 Mar;26(2):88-94 - PubMed
  86. J Clin Oncol. 2004 Jul 15;22(14):2918-26 - PubMed
  87. J Clin Endocrinol Metab. 2016 Nov;101(11):4085-4093 - PubMed
  88. Expert Rev Respir Med. 2013 Jun;7(3):245-57 - PubMed
  89. Thyroid. 2013 May;23(5):609-16 - PubMed
  90. Appl Environ Microbiol. 2020 Oct 28;86(22): - PubMed
  91. Sci Transl Med. 2012 Sep 12;4(151):151ra124 - PubMed
  92. Health Phys. 2012 Oct;103(4):411-26 - PubMed
  93. Gut. 2021 Jun;70(6):1088-1097 - PubMed
  94. Anesthesiology. 2013 Jul;119(1):166-77 - PubMed
  95. N Engl J Med. 1999 Sep 2;341(10):738-46 - PubMed
  96. Annu Rev Microbiol. 1988;42:441-64 - PubMed
  97. Radiat Res. 1965 May;25:15-24 - PubMed
  98. Science. 2011 May 20;332(6032):970-4 - PubMed
  99. Food Res Int. 2020 Mar;129:108788 - PubMed
  100. J Dent Res. 2020 Sep;99(10):1122-1130 - PubMed
  101. Int J Gynaecol Obstet. 2014 Jul;126(1):37-40 - PubMed
  102. Carcinogenesis. 1994 Nov;15(11):2669-72 - PubMed
  103. In Vivo. 2020 Jan-Feb;34(1):39-50 - PubMed
  104. Metabolites. 2020 Aug 11;10(8): - PubMed
  105. Nature. 2012 May 09;486(7402):222-7 - PubMed
  106. Int J Food Microbiol. 2008 Jul 31;125(3):286-92 - PubMed
  107. Gut Microbes. 2020 Jul 3;11(4):1015-1029 - PubMed
  108. Lab Anim Sci. 1982 Dec;32(6):603-8 - PubMed
  109. Rev Invest Clin. 2018;70(3):130-135 - PubMed
  110. J Clin Microbiol. 2005 Nov;43(11):5721-32 - PubMed
  111. J Dent Res. 1978 Sep-Oct;57(9-10):882-93 - PubMed
  112. Acta Gastroenterol Belg. 2019 Oct-Dec;82(4):519-528 - PubMed
  113. J Pulm Respir Med. 2014 Aug;4(4): - PubMed
  114. Thyroid. 2013 Aug;23(8):1029-36 - PubMed
  115. Int J Mol Sci. 2020 Jul 25;21(15): - PubMed
  116. J Clin Microbiol. 2004 Apr;42(4):1519-27 - PubMed
  117. Proc Natl Acad Sci U S A. 2006 Jan 17;103(3):732-7 - PubMed
  118. Radiat Res. 2011 Jun;175(6):736-45 - PubMed
  119. Biomedicines. 2020 Oct 30;8(11): - PubMed
  120. J Immunol. 2014 Nov 15;193(10):5171-80 - PubMed
  121. Nutrients. 2020 Jun 17;12(6): - PubMed
  122. Head Neck. 2002 Aug;24(8):737-47 - PubMed
  123. mBio. 2019 Mar 12;10(2): - PubMed
  124. Health Phys. 2015 Feb;108(2):149-60 - PubMed
  125. Braz Dent J. 2010;21(4):346-50 - PubMed
  126. Radiat Res. 2012 May;177(5):573-83 - PubMed
  127. Int J Radiat Biol. 2020 Oct;96(10):1228-1235 - PubMed
  128. Ann Intern Med. 2004 Jun 15;140(12):1037-51 - PubMed
  129. Gastroenterology. 2021 Jan;160(1):183-192.e3 - PubMed
  130. J Exp Clin Cancer Res. 2019 Dec 16;38(1):493 - PubMed
  131. Nutrients. 2017 Sep 15;9(9): - PubMed
  132. Br Dent J. 2020 Oct;229(8):539-543 - PubMed
  133. Radiat Res. 1964 Nov;23:333-49 - PubMed
  134. Nutrients. 2013 May 29;5(6):1869-912 - PubMed
  135. Exp Mol Med. 2018 Jan 26;50(1):e433 - PubMed
  136. Trends Genet. 2013 Jan;29(1):51-8 - PubMed
  137. Mil Med. 2004 Mar;169(3):194-7 - PubMed
  138. Oral Dis. 2015 Jan;21(1):17-30 - PubMed
  139. Maturitas. 2014 Nov;79(3):349-54 - PubMed
  140. Cell. 2013 Jul 18;154(2):274-84 - PubMed
  141. Ocul Surf. 2020 Apr;18(2):335-344 - PubMed
  142. Shock. 2017 Oct;48(4):441-448 - PubMed
  143. Radiother Oncol. 2018 Oct;129(1):44-51 - PubMed
  144. Eur J Clin Nutr. 2016 Feb;70(2):170-4 - PubMed
  145. Front Cell Infect Microbiol. 2020 Oct 21;10:541178 - PubMed
  146. Int J Mol Sci. 2018 Sep 11;19(9): - PubMed
  147. Ann Otol Rhinol Laryngol. 2019 Dec;128(12):1116-1121 - PubMed
  148. Front Oncol. 2020 Feb 12;10:120 - PubMed
  149. Clin Exp Pharmacol Physiol. 2019 Dec;46(12):1084-1091 - PubMed
  150. Eur J Obstet Gynecol Reprod Biol. 2008 Nov;141(1):54-7 - PubMed
  151. Int J Radiat Oncol Biol Phys. 2011 Nov 15;81(4):e207-13 - PubMed
  152. Head Neck Pathol. 2019 Mar;13(1):25-32 - PubMed
  153. Science. 2005 Mar 25;307(5717):1915-20 - PubMed
  154. Radiat Res. 2016 Sep;186(3):219-34 - PubMed
  155. Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1:4680-7 - PubMed
  156. Rev Endocr Metab Disord. 2000 Apr;1(3):197-203 - PubMed
  157. Microbiome. 2019 Feb 26;7(1):31 - PubMed
  158. Clin Ther. 2015 May 1;37(5):996-1009.e7 - PubMed
  159. J Clin Invest. 2007 Aug;117(8):2197-204 - PubMed
  160. F1000Prime Rep. 2014 Dec 01;6:118 - PubMed
  161. Int J Mol Sci. 2016 Oct 26;17(11): - PubMed
  162. Immunol Rev. 2017 Sep;279(1):70-89 - PubMed
  163. Radiat Res. 2020 Sep 16;194(3):315-344 - PubMed
  164. FEMS Microbiol Ecol. 2015 Sep;91(9):fiv091 - PubMed
  165. FEMS Microbiol Ecol. 2005 Oct 1;54(2):219-31 - PubMed
  166. Support Care Cancer. 2020 Jun;28(6):2683-2691 - PubMed
  167. Occup Environ Med. 2001 Aug;58(8):535-9 - PubMed
  168. J Microbiol Methods. 2009 Dec;79(3):266-71 - PubMed
  169. PLoS One. 2019 Sep 11;14(9):e0206484 - PubMed
  170. PLoS One. 2010 May 17;5(5):e10598 - PubMed
  171. Mediators Inflamm. 2002 Apr;11(2):81-5 - PubMed
  172. Laryngoscope. 2007 Apr;117(4):737-42 - PubMed
  173. Radiat Res. 2001 Mar;155(3):409-16 - PubMed
  174. Int J Radiat Oncol Biol Phys. 2015 Feb 1;91(2):360-7 - PubMed
  175. Protein Cell. 2010 Aug;1(8):718-25 - PubMed
  176. Int J Mol Sci. 2020 Nov 03;21(21): - PubMed
  177. Gut. 2009 Aug;58(8):1091-103 - PubMed
  178. Microbiome. 2017 May 12;5(1):53 - PubMed
  179. J Proteome Res. 2017 May 5;16(5):2091-2100 - PubMed
  180. Nutr Rev. 2012 Aug;70 Suppl 1:S38-44 - PubMed
  181. Radiat Environ Biophys. 2018 Nov;57(4):419-426 - PubMed
  182. Comp Med. 2014 Dec;64(6):456-63 - PubMed
  183. PLoS Comput Biol. 2012;8(12):e1002808 - PubMed
  184. Clin Cancer Res. 2019 Nov 1;25(21):6487-6500 - PubMed
  185. Exp Dermatol. 2016 Dec;25(12):937-944 - PubMed
  186. Free Radic Biol Med. 2019 Dec;145:223-236 - PubMed
  187. Radiat Res. 2020 Jul 8;194(1):1-8 - PubMed
  188. Int J Radiat Biol Relat Stud Phys Chem Med. 1988 May;53(5):709-16 - PubMed
  189. Int J Mol Sci. 2019 Sep 17;20(18): - PubMed
  190. Menopause. 2014 May;21(5):450-8 - PubMed
  191. Nature. 2012 Sep 13;489(7415):220-30 - PubMed
  192. PLoS One. 2017 Jun 2;12(6):e0178870 - PubMed
  193. Am J Respir Crit Care Med. 2011 Oct 15;184(8):957-63 - PubMed
  194. Radiat Oncol. 2021 Jan 13;16(1):9 - PubMed
  195. Aliment Pharmacol Ther. 2018 Jan;47(1):26-42 - PubMed
  196. Microorganisms. 2019 Apr 03;7(4): - PubMed
  197. Gut. 2012 Jun;61(6):829-38 - PubMed
  198. N Engl J Med. 2013 Jan 31;368(5):407-15 - PubMed
  199. Science. 2015 Nov 27;350(6264):1084-9 - PubMed
  200. ISME J. 2010 Aug;4(8):962-74 - PubMed
  201. Annu Rev Pharmacol Toxicol. 2020 Jan 6;60:477-502 - PubMed
  202. Microbes Infect. 2016 Jun;18(6):399-405 - PubMed
  203. Nat Rev Microbiol. 2014 Oct;12(10):661-72 - PubMed
  204. Nat Rev Cancer. 2017 May;17(5):271-285 - PubMed
  205. J Oral Microbiol. 2020 Feb 4;12(1):1723975 - PubMed
  206. Am J Physiol Gastrointest Liver Physiol. 2020 Mar 1;318(3):G439-G450 - PubMed
  207. ACS Omega. 2020 Feb 05;5(6):2967-2977 - PubMed
  208. Mucosal Immunol. 2012 Jan;5(1):7-18 - PubMed
  209. Int J Radiat Oncol Biol Phys. 2021 Jan 1;109(1):145-150 - PubMed
  210. Health Phys. 2019 Mar;116(3):305-338 - PubMed
  211. J Radiat Res. 2018 Apr 1;59(suppl_2):ii54-ii64 - PubMed
  212. J Neurol Surg B Skull Base. 2017 Aug;78(4):331-336 - PubMed
  213. Vet Pathol. 2015 May;52(3):445-55 - PubMed
  214. J Immunol. 2002 Jan 1;168(1):57-64 - PubMed
  215. Sci Rep. 2017 Mar 27;7(1):441 - PubMed
  216. J Pharm Pharm Sci. 2020;23:404-411 - PubMed
  217. Clin Oncol (R Coll Radiol). 2011 May;23(4):251-60 - PubMed
  218. Health Phys. 2016 Nov;111(5):410-9 - PubMed
  219. Aliment Pharmacol Ther. 2014 Sep;40(5):409-21 - PubMed
  220. J Exp Med. 2007 Aug 6;204(8):1891-900 - PubMed
  221. Clin Microbiol Infect. 2005 Jun;11(6):472-9 - PubMed
  222. Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20858-63 - PubMed
  223. JPEN J Parenter Enteral Nutr. 2020 Sep;44(7):1308-1317 - PubMed
  224. PLoS Biol. 2016 Aug 19;14(8):e1002533 - PubMed
  225. Cell Mol Gastroenterol Hepatol. 2019;7(2):255-274 - PubMed
  226. Ophthalmic Plast Reconstr Surg. 2020 Jan/Feb;36(1):80-85 - PubMed
  227. Pulmonology. 2020 Nov - Dec;26(6):333-334 - PubMed
  228. Radiat Prot Dosimetry. 2018 Dec 1;182(1):53-57 - PubMed
  229. Adv Nutr. 2019 Jan 1;10(1):133-147 - PubMed
  230. Nutr Clin Pract. 2012 Apr;27(2):195-200 - PubMed
  231. Thyroid. 2016 Dec;26(12):1761-1767 - PubMed
  232. Mol Cell Biochem. 2014 Aug;393(1-2):133-43 - PubMed
  233. Radiat Res. 2010 Mar;173(3):319-32 - PubMed
  234. J Exp Med. 2020 Oct 5;217(10): - PubMed
  235. Proc Natl Acad Sci U S A. 1985 Oct;82(20):6955-9 - PubMed
  236. Curr Gastroenterol Rep. 2010 Oct;12(5):340-8 - PubMed
  237. Nutrition. 2002 Oct;18(10):904-12 - PubMed
  238. Sci Transl Med. 2009 Nov 11;1(6):6ra14 - PubMed
  239. EMBO Mol Med. 2017 Apr;9(4):448-461 - PubMed
  240. Nature. 2011 May 12;473(7346):174-80 - PubMed
  241. mSystems. 2020 Sep 8;5(5): - PubMed
  242. Oncol Nurs Forum. 2019 Mar 1;46(2):E48-E59 - PubMed
  243. Microorganisms. 2020 Sep 29;8(10): - PubMed
  244. Diabetes. 2014 Feb;63(2):632-44 - PubMed
  245. Health Phys. 2012 Oct;103(4):343-55 - PubMed
  246. J Clin Gastroenterol. 2019 Mar;53 Suppl 1:S1-S41 - PubMed
  247. Wound Repair Regen. 2016 Jan-Feb;24(1):163-74 - PubMed
  248. Micron. 2002;33(2):167-78 - PubMed
  249. EBioMedicine. 2017 Apr;18:23-31 - PubMed
  250. J Gastrointest Surg. 2018 Jun;22(6):1112-1123 - PubMed
  251. Front Cell Infect Microbiol. 2021 Jan 07;10:601573 - PubMed
  252. J Radiat Res. 2019 Jul 1;60(4):442-450 - PubMed
  253. Biomed Res Int. 2013;2013:123241 - PubMed
  254. PLoS One. 2010 Jan 05;5(1):e8578 - PubMed
  255. Int J Cosmet Sci. 2020 Apr;42(2):116-126 - PubMed
  256. Radiat Res. 2019 Jan;191(1):107-121 - PubMed
  257. Front Immunol. 2020 Sep 25;11:2192 - PubMed
  258. Health Phys. 2018 Jan;114(1):32-42 - PubMed
  259. ISME J. 2011 Mar;5(3):519-31 - PubMed
  260. Am J Clin Nutr. 1999 May;69(5):1035S-1045S - PubMed
  261. Gut. 2019 Jun;68(6):1003-1013 - PubMed
  262. Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13254-9 - PubMed
  263. J Clin Gastroenterol. 1979 Mar;1(1):9-39 - PubMed
  264. Cell. 2013 Jan 17;152(1-2):39-50 - PubMed
  265. Int J Radiat Biol. 2020 Sep 22;:1-17 - PubMed
  266. Health Phys. 2012 Oct;103(4):427-53 - PubMed
  267. Cancers (Basel). 2020 May 22;12(5): - PubMed
  268. Tohoku J Exp Med. 1965 Apr 25;85:257-63 - PubMed
  269. mSystems. 2018 Mar 20;3(2): - PubMed
  270. J Leukoc Biol. 2011 May;89(5):685-95 - PubMed
  271. Maturitas. 2016 Sep;91:42-50 - PubMed
  272. iScience. 2019 May 31;15:211-222 - PubMed
  273. Benef Microbes. 2019 Apr 19;10(3):225-236 - PubMed
  274. J Cancer Res Ther. 2019 Oct-Dec;15(6):1383-1391 - PubMed
  275. In Vivo. 2010 Jan-Feb;24(1):9-19 - PubMed
  276. Can J Gastroenterol Hepatol. 2018 Sep 2;2018:1394379 - PubMed
  277. Radiat Res. 1971 Mar;45(3):613-28 - PubMed
  278. Nutrients. 2019 Oct 01;11(10): - PubMed
  279. Cancer. 2006 Dec 1;107(11):2525-34 - PubMed
  280. Drug Discov Today Dis Mech. 2008 Jun 1;5(2):145-152 - PubMed
  281. Gut. 2018 Jan;67(1):97-107 - PubMed
  282. J Nucl Med. 2001 May;42(5):738-43 - PubMed
  283. Int J Radiat Oncol Biol Phys. 2021 Feb 1;109(2):581-593 - PubMed
  284. Cell Microbiol. 2018 Dec;20(12):e12966 - PubMed
  285. Nat Immunol. 2012 May;13(5):449-56 - PubMed
  286. J Med Microbiol. 2005 Nov;54(Pt 11):1093-1101 - PubMed
  287. Mycoses. 2019 Aug;62(8):620-637 - PubMed
  288. Cell. 2016 Jan 28;164(3):337-40 - PubMed
  289. Front Microbiol. 2019 Jul 09;10:1576 - PubMed
  290. Gut Microbes. 2020 Jul 3;11(4):789-806 - PubMed
  291. Case Rep Gastrointest Med. 2019 Jan 2;2019:2543808 - PubMed
  292. J Nucl Med. 1998 Sep;39(9):1551-4 - PubMed
  293. J Dent Res. 1975 Jul-Aug;54(4):740-50 - PubMed
  294. Expert Rev Gastroenterol Hepatol. 2019 Nov;13(11):1039-1048 - PubMed
  295. J Appl Bacteriol. 1981 Feb;50(1):95-106 - PubMed
  296. J Cell Physiol. 2017 Jul;232(7):1681-1688 - PubMed
  297. Invest Ophthalmol Vis Sci. 2020 Feb 7;61(2):18 - PubMed
  298. Nat Rev Immunol. 2004 Mar;4(3):211-22 - PubMed
  299. Lancet. 2017 Mar 25;389(10075):1218-1228 - PubMed
  300. Lancet. 2012 Nov 24;380(9856):1810-1 - PubMed
  301. J Infect Dis. 2002 Dec 1;186 Suppl 2:S254-8 - PubMed
  302. J Invest Dermatol. 2017 Jun;137(6):1213-1214 - PubMed
  303. Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1:4586-91 - PubMed
  304. Radiat Res. 1963 Nov;20:477-83 - PubMed
  305. Metabolites. 2019 May 15;9(5): - PubMed
  306. J Oral Maxillofac Pathol. 2020 Jan-Apr;24(1):117-124 - PubMed

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