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Mokhtare M, Chaharmahali A, Bahardoust M, et al. The effect of adding duloxetine to lansoprazole on symptom and quality of life improvement in patients with gastroesophageal reflux diseases: A randomized double-blind clinical trial. J Res Med Sci. 2021;26:4doi: 10.4103/jrms.JRMS_300_19.
Mokhtare, M., Chaharmahali, A., Bahardoust, M., Ghanbari, A., Sarveazad, A., Naghshin, R., & Abbaskhanidavanloo, F. (2021). The effect of adding duloxetine to lansoprazole on symptom and quality of life improvement in patients with gastroesophageal reflux diseases: A randomized double-blind clinical trial. Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, 264. https://doi.org/10.4103/jrms.JRMS_300_19
Mokhtare, Marjan, et al. "The effect of adding duloxetine to lansoprazole on symptom and quality of life improvement in patients with gastroesophageal reflux diseases: A randomized double-blind clinical trial." Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences vol. 26 (2021): 4. doi: https://doi.org/10.4103/jrms.JRMS_300_19
Mokhtare M, Chaharmahali A, Bahardoust M, Ghanbari A, Sarveazad A, Naghshin R, Abbaskhanidavanloo F. The effect of adding duloxetine to lansoprazole on symptom and quality of life improvement in patients with gastroesophageal reflux diseases: A randomized double-blind clinical trial. J Res Med Sci. 2021 Jan 28;26:4. doi: 10.4103/jrms.JRMS_300_19. eCollection 2021. PMID: 34084183; PMCID: PMC8103956.
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J Res Med Sci. 2021 Jan 28;26:4. doi: 10.4103/jrms.JRMS_300_19. eCollection 2021.

The effect of adding duloxetine to lansoprazole on symptom and quality of life improvement in patients with gastroesophageal reflux diseases: A randomized double-blind clinical trial.

Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences

Marjan Mokhtare, Arezoo Chaharmahali, Mansour Bahardoust, Atefeh Ghanbari, Arash Sarveazad, Roozbeh Naghshin, Farbod Abbaskhanidavanloo

Affiliations

  1. Colorectal Research Center, Iran University of Medical Sciences, Tehran, Iran.
  2. Department Internal Medicine, Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
  3. Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
  4. Minimally Invasive Surgery Research Center, Iran University of Medical Sciences, Tehran, Iran.
  5. Nursing Care Research Center, Iran University of Medical Sciences, Tehran, Iran.
  6. Department of Computer Science, Memorial University of Newfoundland and Larador, St. John's, Canada.

PMID: 34084183 PMCID: PMC8103956 DOI: 10.4103/jrms.JRMS_300_19

Abstract

BACKGROUND: Gastroesophageal reflux disease (GERD) is a common upper gastrointestinal disorder with a negative impact on the quality of life. This study was aimed to assess the effect of adding duloxetine to lansoprazole on the symptom and quality of life improvement in GERD patients.

MATERIALS AND METHODS: Seventy adult patients with a complaint of heartburn and regurgitation were enrolled in this randomized trial. Patients with a history of atypical symptoms, advanced systemic disease, medication-induced symptom, structural lesion in endoscopy, allergy to the medication, and unco-operative were excluded. The patients randomly (computer generated table) assigned in Groups A who received lansoprazole 30 mg plus placebo daily and Group B, in which duloxetine 30 mg daily replaced by placebo during 4 weeks. All of participants, care-givers, and outcomes assessors were blinded. Basic demographic data, symptom severity score, depression and anxiety Beck score, and quality of life questionnaire were recorded at the starting and ending of treatment.

RESULTS: Fifty-four patients have completed the study. The mean difference of Anxiety Beck score (13, 95% confidence interval [CI] [10-16],

CONCLUSION: We found that the combination of duloxetine and lansoprazole is a safe and tolerable regimen, and it can significantly improve anxiety, heartburn, coffee consumption, the quality of sleep, and life in patients who suffer from the symptoms of GERD.

Copyright: © 2021 Journal of Research in Medical Sciences.

Keywords: Anxiety; duloxetine; gastro-esophageal reflux disease; heartburn; quality of life

Conflict of interest statement

There are no conflicts of interest.

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