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Morneau-Vaillancourt G, Andlauer TFM, Ouellet-Morin I, et al. Polygenic scores differentially predict developmental trajectories of subtypes of social withdrawal in childhood. J Child Psychol Psychiatry. 2021;62(11):1320-1329doi: 10.1111/jcpp.13459.
Morneau-Vaillancourt, G., Andlauer, T. F. M., Ouellet-Morin, I., Paquin, S., Brendgen, M. R., Vitaro, F., Gouin, J. P., Séguin, J. R., Gagnon, �. �., Cheesman, R., Forget-Dubois, N., Rouleau, G. A., Turecki, G., Tremblay, R. E., Côté, S. M., Dionne, G., & Boivin, M. (2021). Polygenic scores differentially predict developmental trajectories of subtypes of social withdrawal in childhood. Journal of child psychology and psychiatry, and allied disciplines, 62(11), 1320-1329. https://doi.org/10.1111/jcpp.13459
Morneau-Vaillancourt, Geneviève, et al. "Polygenic scores differentially predict developmental trajectories of subtypes of social withdrawal in childhood." Journal of child psychology and psychiatry, and allied disciplines vol. 62,11 (2021): 1320-1329. doi: https://doi.org/10.1111/jcpp.13459
Morneau-Vaillancourt G, Andlauer TFM, Ouellet-Morin I, Paquin S, Brendgen MR, Vitaro F, Gouin JP, Séguin JR, Gagnon É, Cheesman R, Forget-Dubois N, Rouleau GA, Turecki G, Tremblay RE, Côté SM, Dionne G, Boivin M. Polygenic scores differentially predict developmental trajectories of subtypes of social withdrawal in childhood. J Child Psychol Psychiatry. 2021 Nov;62(11):1320-1329. doi: 10.1111/jcpp.13459. Epub 2021 Jun 03. PMID: 34085288.
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J Child Psychol Psychiatry. 2021 Nov;62(11):1320-1329. doi: 10.1111/jcpp.13459. Epub 2021 Jun 03.

Polygenic scores differentially predict developmental trajectories of subtypes of social withdrawal in childhood.

Journal of child psychology and psychiatry, and allied disciplines

Geneviève Morneau-Vaillancourt, Till F M Andlauer, Isabelle Ouellet-Morin, Stéphane Paquin, Mara R Brendgen, Frank Vitaro, Jean-Philippe Gouin, Jean R Séguin, Éloi Gagnon, Rosa Cheesman, Nadine Forget-Dubois, Guy A Rouleau, Gustavo Turecki, Richard E Tremblay, Sylvana M Côté, Ginette Dionne, Michel Boivin

Affiliations

  1. École de psychologie, Université Laval, Quebec City, QC, Canada.
  2. Department of Neurology, Technical University of Munich, Munich, Germany.
  3. École de criminologie, Université de Montréal, Montreal, QC, Canada.
  4. Department of Psychology, The Pennsylvania State University, State College, PA, USA.
  5. Département de psychologie, Université du Québec à Montréal, Montreal, QC, Canada.
  6. École de psychoéducation, Université de Montréal, Montreal, QC, Canada.
  7. Department of Psychology, Concordia University, Montreal, QC, Canada.
  8. Département de psychiatrie et d'addictologie, Université de Montréal, Montreal, QC, Canada.
  9. Centre de recherche du CHU Sainte-Justine, Montreal, QC, Canada.
  10. Promenta Research Centre, University of Oslo, Oslo, Norway.
  11. Institut-hôpital neurologique de Montréal, McGill University, Montreal, QC, Canada.
  12. Douglas Research Centre, McGill University, Montreal, QC, Canada.
  13. Départements de pédiatrie et de psychologie, Université de Montréal, Montreal, QC, Canada.
  14. Département de médecine sociale et préventive, Université de Montréal, Montreal, QC, Canada.

PMID: 34085288 DOI: 10.1111/jcpp.13459

Abstract

BACKGROUND: Children who consistently withdraw from social situations face increased risk for later socioemotional difficulties. Twin studies indicate that genetic factors substantially account for the persistence of social withdrawal over time. However, the molecular genetic etiology of chronic courses of social wariness and preference for solitude, two dimensions of social withdrawal, remains undocumented. The objectives of the present study were (a) to identify high-risk trajectories for social wariness and preference for solitude in childhood and (b) to examine whether falling on these high-risk trajectories can be predicted by specific polygenic scores for mental health traits and disorders and by a general polygenic predisposition to these traits.

METHODS: Teachers evaluated 971 genotyped children at five occasions (age 6 to 12 years) from two prospective longitudinal studies, the Quebec Newborn Twin Study and the Quebec Longitudinal Study of Child Development. Developmental trajectories for social wariness and preference for solitude were identified. We tested whether polygenic scores for attention deficit hyperactivity disorder, autism spectrum disorder, depression, loneliness, and subjective well-being, as well as a general mental health genetic risk score derived across these traits, were associated with the developmental trajectories.

RESULTS: Polygenic scores differentially predicted social wariness and preference for solitude. Only the loneliness polygenic score significantly predicted the high trajectory for social wariness. By contrast, the general mental health genetic risk score factor was associated with the trajectory depicting high-chronic preference for solitude.

CONCLUSIONS: Distinct associations were uncovered between the polygenic scores, social wariness, and preference for solitude.

© 2021 Association for Child and Adolescent Mental Health.

Keywords: Social withdrawal; polygenic scores; preference for solitude; social wariness; trajectories

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