Sheng Wu Gong Cheng Xue Bao. 2021 May 25;37(5):1541-1563. doi: 10.13345/j.cjb.200688.

[Metabolic regulation in constructing microbial cell factories].

Sheng wu gong cheng xue bao = Chinese journal of biotechnology

[Article in Chinese]
Yang Liu, Qingxuan Mu, Ya'nan Shi, Bo Yu

PMID: 34085442 DOI: 10.13345/j.cjb.200688

Abstract

The regulation of the expression of genes involved in metabolic pathways, termed as metabolic regulation, is vital to construct efficient microbial cell factories. With the continuous breakthroughs in synthetic biology, the mining and artificial design of high-quality regulatory elements have substantially improved our ability to modify and regulate cellular metabolic networks and its activities. The research on metabolic regulation has also evolved from the static regulation of single genes to the intelligent and precise dynamic regulation at the systems level. This review briefly summarizes the advances of metabolic regulation technologies in the past 30 years.

Keywords: metabolic engineering; microbial cell factories; regulation of gene expression; synthetic biology

MeSH terms

• Metabolic Engineering*
• Metabolic Networks and Pathways / genetics
• Synthetic Biology*

Publication Types

• Journal Article
• Review