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Hypertension. 2021 Aug;78(2):376-386. doi: 10.1161/HYPERTENSIONAHA.120.16181. Epub 2021 Jun 21.

Association of Apparent Treatment-Resistant Hypertension With Differential Risk of End-Stage Kidney Disease Across Racial Groups in the Million Veteran Program.

Hypertension (Dallas, Tex. : 1979)

Elvis A Akwo, Cassianne Robinson-Cohen, Cecilia P Chung, Shailja C Shah, Nancy J Brown, T Alp Ikizler, Otis D Wilson, Bryce X Rowan, Megan M Shuey, Edward D Siew, James M Luther, Ayush Giri, Jacklyn N Hellwege, Digna R Velez Edwards, Christianne L Roumie, Ran Tao, Phil S Tsao, J Michael Gaziano, Peter W F Wilson, Christopher J O'Donnell, Todd L Edwards, Csaba P Kovesdy, Adriana M Hung,

Affiliations

  1. Division of Nephrology and Hypertension, Department of Medicine (E.A.A., C.R.-C., T.A.I., O.D.W., E.D.S., A.M.H.).
  2. Vanderbilt Center for Kidney Disease (E.A.A., C.R.-C., T.A.I., E.D.S., A.M.H.).
  3. Tennessee Valley Healthcare System, Nashville, VA (E.A.A., C.R.-C., C.P.C., S.C.S., T.A.I., O.D.W., E.D.S., A.M.H.).
  4. Division of Rheumatology, Department of Medicine (C.P.C.), Vanderbilt University Medical Center, Nashville, TN.
  5. Vanderbilt Genetics Institute (C.P.C., A.G., R.T.).
  6. Division of Gastroenterology, Hepatology and Nutrition (S.C.S.), Vanderbilt University Medical Center, Nashville, TN.
  7. Department of Medicine (N.J.B., J.M.L.), Vanderbilt University Medical Center, Nashville, TN.
  8. Yale School of Medicine, New Haven, CT (N.J.B.).
  9. Department of Biostatistics, Vanderbilt School of Medicine (B.X.R, R.T.).
  10. Division of Genetic Medicine, Department of Medicine (M.M.S., J.N.H.), Vanderbilt University Medical Center, Nashville, TN.
  11. Division of Quantitative Sciences, Department of Obstetrics and Gynecology (D.R.V.E., A.G.), Vanderbilt University Medical Center, Nashville, TN.
  12. Department of Biomedical Informatics (D.R.V.E.), Vanderbilt University Medical Center, Nashville, TN.
  13. Institute of Medicine and Public Health (D.R.V.E., T.L.E.), Vanderbilt University Medical Center, Nashville, TN.
  14. Veteran Administration Tennessee Valley VA Health Care System Geriatric Research Education Clinical Center (GRECC), Nashville (C.L.R.).
  15. VA Palo Alto Health Care System (P.S.T.).
  16. Department of Medicine, Stanford University School of Medicine, CA (P.S.T.).
  17. Stanford Cardiovascular Institute (P.S.T.).
  18. VA Boston Healthcare System, MA (J.M.G.).
  19. Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (J.M.G., C.J.O.).
  20. Epidemiology and Genomic Medicine, Atlanta VAMC, Decatur, GA (P.W.F.W.).
  21. Cardiology Division, Emory School of Medicine, Atlanta, GA (P.W.F.W.).
  22. VA Boston Healthcare System, Section of Cardiology (C.J.O.).
  23. Division of Epidemiology, Department of Medicine (T.L.E.), Vanderbilt University Medical Center, Nashville, TN.
  24. Memphis VA Medical Center, TN (C.P.K.).
  25. University of Tennessee Health Science Center, Memphis (C.P.K.).
  26. Vanderbilt Precision Nephrology Program (A.M.H.), Vanderbilt University Medical Center, Nashville, TN.

PMID: 34148359 PMCID: PMC8364328 DOI: 10.1161/HYPERTENSIONAHA.120.16181

Abstract

[Figure: see text].

Keywords: Treatment-resistant hypertension; apolipoprotein L1 variants; end-stage kidney disease; myocardial infarction; race; stroke

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