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Berland C, Small DM, Luquet S, et al. Dietary lipids as regulators of reward processes: multimodal integration matters. Trends Endocrinol Metab. 2021;32(9):693-705doi: 10.1016/j.tem.2021.05.008.
Berland, C., Small, D. M., Luquet, S., & Gangarossa, G. (2021). Dietary lipids as regulators of reward processes: multimodal integration matters. Trends in endocrinology and metabolism: TEM, 32(9), 693-705. https://doi.org/10.1016/j.tem.2021.05.008
Berland, Chloé, et al. "Dietary lipids as regulators of reward processes: multimodal integration matters." Trends in endocrinology and metabolism: TEM vol. 32,9 (2021): 693-705. doi: https://doi.org/10.1016/j.tem.2021.05.008
Berland C, Small DM, Luquet S, Gangarossa G. Dietary lipids as regulators of reward processes: multimodal integration matters. Trends Endocrinol Metab. 2021 Sep;32(9):693-705. doi: 10.1016/j.tem.2021.05.008. Epub 2021 Jun 17. PMID: 34148784.
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Trends Endocrinol Metab. 2021 Sep;32(9):693-705. doi: 10.1016/j.tem.2021.05.008. Epub 2021 Jun 17.

Dietary lipids as regulators of reward processes: multimodal integration matters.

Trends in endocrinology and metabolism: TEM

Chloé Berland, Dana M Small, Serge Luquet, Giuseppe Gangarossa

Affiliations

  1. Université de Paris, BFA, UMR 8251, CNRS, F-75013 Paris, France; Department of Medicine, The Naomi Berrie Diabetes Center, Columbia University, New York, NY 10032, USA.
  2. Department of Psychiatry, and the Modern Diet and Physiology Research Center, Yale University School of Medicine, New Haven, CT 06510, USA.
  3. Université de Paris, BFA, UMR 8251, CNRS, F-75013 Paris, France. Electronic address: [email protected].
  4. Université de Paris, BFA, UMR 8251, CNRS, F-75013 Paris, France. Electronic address: [email protected].

PMID: 34148784 DOI: 10.1016/j.tem.2021.05.008

Abstract

The abundance of energy-dense and palatable diets in the modern food environment tightly contributes to the obesity pandemic. The reward circuit participates to the regulation of body homeostasis by integrating energy-related signals with neural substrates encoding cognitive and motivational components of feeding behaviors. Obesity and lipid-rich diets alter dopamine (DA) transmission leading to reward dysfunctions and food overconsumption. Recent reports indicate that dietary lipids can act, directly and indirectly, as functional modulators of the DA circuit. This raises the possibility that nutritional or genetic conditions affecting 'lipid sensing' mechanisms might lead to maladaptations of the DA system. Here, we discuss the most recent findings connecting dietary lipid sensing with DA signaling and its multimodal influence on circuits regulating food-reward processes.

Copyright © 2021 Elsevier Ltd. All rights reserved.

Keywords: circuits; dopamine; feeding behavior; integrative physiology; lipid sensing; nutrients

Conflict of interest statement

Declaration of interests The authors declare no conflicts of interest.

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