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Coelho FDS, Barros DE, Santos FA, et al. Minimally invasive esophagectomy versus open esophagectomy: A systematic review and meta-analysis. Eur J Surg Oncol. 2021;47(11):2742-2748doi: 10.1016/j.ejso.2021.06.012.
Coelho, F. D. S., Barros, D. E., Santos, F. A., Meireles, F. C., Maia, F. C., Trovisco, R. A., Machado, T. M., & Barbosa, J. A. (2021). Minimally invasive esophagectomy versus open esophagectomy: A systematic review and meta-analysis. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 47(11), 2742-2748. https://doi.org/10.1016/j.ejso.2021.06.012
Coelho, Francisca Dos S, et al. "Minimally invasive esophagectomy versus open esophagectomy: A systematic review and meta-analysis." European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology vol. 47,11 (2021): 2742-2748. doi: https://doi.org/10.1016/j.ejso.2021.06.012
Coelho FDS, Barros DE, Santos FA, Meireles FC, Maia FC, Trovisco RA, Machado TM, Barbosa JA. Minimally invasive esophagectomy versus open esophagectomy: A systematic review and meta-analysis. Eur J Surg Oncol. 2021 Nov;47(11):2742-2748. doi: 10.1016/j.ejso.2021.06.012. Epub 2021 Jun 13. PMID: 34148823.
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Eur J Surg Oncol. 2021 Nov;47(11):2742-2748. doi: 10.1016/j.ejso.2021.06.012. Epub 2021 Jun 13.

Minimally invasive esophagectomy versus open esophagectomy: A systematic review and meta-analysis.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

Francisca Dos S Coelho, Diana E Barros, Filipa A Santos, Flávia C Meireles, Francisca C Maia, Rita A Trovisco, Teresa M Machado, José A Barbosa

Affiliations

  1. Faculdade de Medicina da Universidade do Porto, Alameda Professor Hernâni Monteiro, 4200-319, Porto, Portugal. Electronic address: [email protected].
  2. Faculdade de Medicina da Universidade do Porto, Alameda Professor Hernâni Monteiro, 4200-319, Porto, Portugal.
  3. Faculdade de Medicina da Universidade do Porto, Alameda Professor Hernâni Monteiro, 4200-319, Porto, Portugal; Serviço de Cirurgia, Centro Hospitalar Universitário de São João, E.P.E, Alameda Professor Hernâni Monteiro, 4200-319, Porto, Portugal.

PMID: 34148823 DOI: 10.1016/j.ejso.2021.06.012

Abstract

The paradigm of the treatment of esophageal cancer has been changing with the increasing use of minimally invasive esophagectomy (MIE) in detriment of open esophagectomy (OE). We aimed to perform a meta-analysis to evaluate and compare these two techniques in terms of mortality and associated complications. The literature search was conducted in MEDLINE and U.S. National Library of Medicine Clinical Trials, considering eligible articles since 2015 to 2020. Clinical trials and observational studies were included. We presented results as mean differences with 95% confidence intervals and calculation of heterogeneity associated to the included studies. Thirty-one articles were included with a total of 34,465 participants diagnosed with esophageal adenocarcinoma or squamous cell carcinoma. MIE had tendency towards a decrease in 30- and 90- day mortality after surgery, but no statistically significative results were found. Major cardiovascular and respiratory complications were less frequent in the MIE group, despite high heterogeneity. Also, MIE might contribute to a decrease of minor post-operative complications, to an increase need of a second surgical intervention, to a greater risk for vocal cord lesions; but these results were not statistically significant. Additionally, no differences were found concerning risk of wound infection and for local and systemic recurrence. MIE may be more beneficial than OE, but these findings should be considered carefully.

Copyright © 2021 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.

Keywords: Esophageal cancer; Minimally invasive esophagectomy; Open esophagectomy

Conflict of interest statement

Declaration of competing interest None.

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