Display options
Cite
Hutka B, Lázár B, Tóth AS, et al. The Nonsteroidal Anti-Inflammatory Drug Ketorolac Alters the Small Intestinal Microbiota and Bile Acids Without Inducing Intestinal Damage or Delaying Peristalsis in the Rat. Front Pharmacol. 2021;12:664177doi: 10.3389/fphar.2021.664177.
Hutka, B., Lázár, B., Tóth, A. S., Ágg, B., László, S. B., Makra, N., Ligeti, B., Scheich, B., Király, K., Al-Khrasani, M., Szabó, D., Ferdinandy, P., Gyires, K., & Zádori, Z. S. (2021). The Nonsteroidal Anti-Inflammatory Drug Ketorolac Alters the Small Intestinal Microbiota and Bile Acids Without Inducing Intestinal Damage or Delaying Peristalsis in the Rat. Frontiers in pharmacology, 12664177. https://doi.org/10.3389/fphar.2021.664177
Hutka, Barbara, et al. "The Nonsteroidal Anti-Inflammatory Drug Ketorolac Alters the Small Intestinal Microbiota and Bile Acids Without Inducing Intestinal Damage or Delaying Peristalsis in the Rat." Frontiers in pharmacology vol. 12 (2021): 664177. doi: https://doi.org/10.3389/fphar.2021.664177
Hutka B, Lázár B, Tóth AS, Ágg B, László SB, Makra N, Ligeti B, Scheich B, Király K, Al-Khrasani M, Szabó D, Ferdinandy P, Gyires K, Zádori ZS. The Nonsteroidal Anti-Inflammatory Drug Ketorolac Alters the Small Intestinal Microbiota and Bile Acids Without Inducing Intestinal Damage or Delaying Peristalsis in the Rat. Front Pharmacol. 2021 Jun 04;12:664177. doi: 10.3389/fphar.2021.664177. eCollection 2021. PMID: 34149417; PMCID: PMC8213092.
Copy Download .nbib Format: NLM
Share it on

Front Pharmacol. 2021 Jun 04;12:664177. doi: 10.3389/fphar.2021.664177. eCollection 2021.

The Nonsteroidal Anti-Inflammatory Drug Ketorolac Alters the Small Intestinal Microbiota and Bile Acids Without Inducing Intestinal Damage or Delaying Peristalsis in the Rat.

Frontiers in pharmacology

Barbara Hutka, Bernadette Lázár, András S Tóth, Bence Ágg, Szilvia B László, Nóra Makra, Balázs Ligeti, Bálint Scheich, Kornél Király, Mahmoud Al-Khrasani, Dóra Szabó, Péter Ferdinandy, Klára Gyires, Zoltán S Zádori

Affiliations

  1. Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary.
  2. Pharmahungary Group, Szeged, Hungary.
  3. Department of Medical Microbiology, Semmelweis University, Budapest, Hungary.
  4. Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, Budapest, Hungary.
  5. 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.

PMID: 34149417 PMCID: PMC8213092 DOI: 10.3389/fphar.2021.664177

[No abstract available.]

Copyright © 2021 Hutka, Lázár, Tóth, Ágg, László, Makra, Ligeti, Scheich, Király, Al-Khrasani, Szabó, Ferdinandy, Gyires and Zádori.

Keywords: bile acid; enteropathy; hyodeoxycholic acid; ketorolac; microbiota; nonsteroidal anti-inflammatory drug; peristalsis

Conflict of interest statement

PF is the founder and CEO of Pharmahungary, a group of R&D companies. BA was employed by Pharmahungary Group. The remaining authors declare that the research was conducted in the absence of any commer

References

  1. Microbiol Immunol. 1996;40(8):553-60 - PubMed
  2. Appl Environ Microbiol. 1999 Jul;65(7):3158-63 - PubMed
  3. Digestion. 2015;91(3):218-32 - PubMed
  4. Chirality. 1999;11(3):201-5 - PubMed
  5. Mucosal Immunol. 2017 Jan;10(1):18-26 - PubMed
  6. Br J Pharmacol. 1976 Jul;57(3):335-40 - PubMed
  7. J Nutr. 2013 Nov;143(11):1691-7 - PubMed
  8. Nature. 2018 Mar 29;555(7698):623-628 - PubMed
  9. J Pharmacol Exp Ther. 1999 Mar;288(3):1288-97 - PubMed
  10. Gastroenterology. 1997 Jan;112(1):109-17 - PubMed
  11. Pain Pract. 2015 Feb;15(2):175-93 - PubMed
  12. Gastroenterology. 2018 Feb;154(3):500-514 - PubMed
  13. Front Pharmacol. 2018 Nov 29;9:1340 - PubMed
  14. Am J Physiol. 1998 Sep;275(3):G425-32 - PubMed
  15. Nature. 2006 Dec 21;444(7122):1027-31 - PubMed
  16. World J Gastroenterol. 2013 Mar 28;19(12):1861-76 - PubMed
  17. PLoS One. 2012;7(7):e41594 - PubMed
  18. Molecules. 2020 Mar 17;25(6): - PubMed
  19. Appl Environ Microbiol. 2006 Oct;72(10):6707-15 - PubMed
  20. Am J Physiol Gastrointest Liver Physiol. 2015 May 1;308(9):G785-93 - PubMed
  21. Am J Physiol Gastrointest Liver Physiol. 2015 Feb 1;308(3):G217-22 - PubMed
  22. Acta Physiol (Oxf). 2011 Jan;201(1):179-92 - PubMed
  23. Gastroenterology. 2000 Sep;119(3):706-14 - PubMed
  24. J Pharmacol Exp Ther. 2013 Jan;344(1):189-95 - PubMed
  25. J Med Invest. 2004 Feb;51(1-2):43-51 - PubMed
  26. Bioinformatics. 2014 Aug 1;30(15):2114-20 - PubMed
  27. Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7563-8 - PubMed
  28. J Pharmacol Exp Ther. 2012 May;341(2):447-54 - PubMed
  29. Am J Pathol. 1969 Feb;54(2):237-49 - PubMed
  30. FEMS Microbiol Rev. 2005 Sep;29(4):625-51 - PubMed
  31. Digestion. 2002;66(1):30-41 - PubMed
  32. Dig Dis Sci. 2006 Apr;51(4):766-74 - PubMed
  33. mBio. 2019 Jan 8;10(1): - PubMed
  34. Front Microbiol. 2015 Jul 28;6:750 - PubMed
  35. Cells. 2019 Mar 15;8(3): - PubMed
  36. Sci Rep. 2016 Sep 23;6:33992 - PubMed
  37. Clin Microbiol Infect. 2016 Feb;22(2):178.e1-178.e9 - PubMed
  38. Gastroenterology. 2000 Jun;118(6):1179-86 - PubMed
  39. J Glob Antimicrob Resist. 2017 Sep;10:70-74 - PubMed
  40. Elife. 2015 Dec 23;4:e08973 - PubMed
  41. Eur J Pharm Sci. 2015 Apr 25;71:93-8 - PubMed
  42. Front Vet Sci. 2018 Aug 28;5:196 - PubMed
  43. Biochem Pharmacol. 2020 Aug;178:114099 - PubMed
  44. Nucleic Acids Res. 2013 Jan;41(Database issue):D590-6 - PubMed
  45. Front Microbiol. 2018 Jun 05;9:1153 - PubMed
  46. Gut. 1969 Dec;10(12):963-72 - PubMed
  47. J Pharmacol Exp Ther. 1995 Jan;272(1):352-6 - PubMed
  48. Sci Rep. 2017 Jan 09;7:40317 - PubMed
  49. Sci Rep. 2020 Jul 6;10(1):11042 - PubMed
  50. Curr Drug Saf. 2014;9(3):196-204 - PubMed
  51. FASEB J. 2013 Sep;27(9):3805-17 - PubMed
  52. J Gastroenterol. 2015 Apr;50(4):387-93 - PubMed
  53. Microb Ecol Health Dis. 2015 May 29;26:27663 - PubMed
  54. Genome Biol. 2014 Mar 03;15(3):R46 - PubMed
  55. Am J Physiol Gastrointest Liver Physiol. 2010 May;298(5):G722-31 - PubMed
  56. Gastroenterology. 2005 May;128(5):1172-8 - PubMed
  57. Neurogastroenterol Motil. 2007 Mar;19(3):225-32 - PubMed
  58. J Lipid Res. 1989 May;30(5):719-30 - PubMed
  59. Gut Microbes. 2016;7(1):22-39 - PubMed
  60. Clin Biochem. 2007 May;40(8):503-10 - PubMed
  61. Cancer Prev Res (Phila). 2016 Sep;9(9):721-31 - PubMed
  62. Gut. 2009 Dec;58(12):1590-6 - PubMed
  63. Gastroenterology. 2013 May;144(5):967-77 - PubMed
  64. Curr Microbiol. 2011 Mar;62(3):1028-33 - PubMed
  65. J Crohns Colitis. 2014 Sep;8(9):1043-54 - PubMed
  66. Am J Physiol. 1996 May;270(5 Pt 1):G804-12 - PubMed
  67. Am J Physiol Gastrointest Liver Physiol. 2015 Jun 15;308(12):G994-1003 - PubMed
  68. Digestion. 2006;73 Suppl 1:136-50 - PubMed
  69. Acta Pharm Sin B. 2015 Mar;5(2):99-105 - PubMed
  70. Arch Toxicol. 2018 Mar;92(3):1249-1265 - PubMed
  71. Biochimie. 2014 Feb;97:28-38 - PubMed
  72. Br J Pharmacol. 2001 Mar;132(6):1299-309 - PubMed
  73. FEMS Microbiol Rev. 2016 Jan;40(1):117-32 - PubMed
  74. Brief Bioinform. 2019 Jul 19;20(4):1125-1136 - PubMed
  75. Prostaglandins. 1977 Aug;14(2):333-41 - PubMed
  76. Physiol Rep. 2017 Mar;5(6): - PubMed
  77. Am J Physiol. 1997 May;272(5 Pt 1):G1249-57 - PubMed

Publication Types