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Dalton KM, Krytska K, Lochmann TL, et al. Venetoclax-based Rational Combinations are Effective in Models of . Mol Cancer Ther. 2021;20(8):1400-1411doi: 10.1158/1535-7163.MCT-20-0710.
Dalton, K. M., Krytska, K., Lochmann, T. L., Sano, R., Casey, C., D'Aulerio, A., Khan, Q. A., Crowther, G. S., Coon, C., Cai, J., Jacob, S., Kurupi, R., Hu, B., Dozmorov, M., Greninger, P., Souers, A. J., Benes, C. H., Mossé, Y. P., & Faber, A. C. (2021). Venetoclax-based Rational Combinations are Effective in Models of . Molecular cancer therapeutics, 20(8), 1400-1411. https://doi.org/10.1158/1535-7163.MCT-20-0710
Dalton, Krista M, et al. "Venetoclax-based Rational Combinations are Effective in Models of ." Molecular cancer therapeutics vol. 20,8 (2021): 1400-1411. doi: https://doi.org/10.1158/1535-7163.MCT-20-0710
Dalton KM, Krytska K, Lochmann TL, Sano R, Casey C, D'Aulerio A, Khan QA, Crowther GS, Coon C, Cai J, Jacob S, Kurupi R, Hu B, Dozmorov M, Greninger P, Souers AJ, Benes CH, Mossé YP, Faber AC. Venetoclax-based Rational Combinations are Effective in Models of . Mol Cancer Ther. 2021 Aug;20(8):1400-1411. doi: 10.1158/1535-7163.MCT-20-0710. Epub 2021 Jun 04. PMID: 34088831.
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Mol Cancer Ther. 2021 Aug;20(8):1400-1411. doi: 10.1158/1535-7163.MCT-20-0710. Epub 2021 Jun 04.

Venetoclax-based Rational Combinations are Effective in Models of .

Molecular cancer therapeutics

Krista M Dalton, Kateryna Krytska, Timothy L Lochmann, Renata Sano, Colleen Casey, Alessia D'Aulerio, Qasim A Khan, Giovanna Stein Crowther, Colin Coon, Jinyang Cai, Sheeba Jacob, Richard Kurupi, Bin Hu, Mikhail Dozmorov, Patricia Greninger, Andrew J Souers, Cyril H Benes, Yael P Mossé, Anthony C Faber

Affiliations

  1. Philips Institute for Oral Health Research, VCU School of Dentistry and Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia.
  2. Division of Oncology and Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
  3. Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
  4. Pharmacyclics, an Abbvie company, Sunnyvale, California.
  5. Center for Cancer Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts.
  6. Department of Pathology, Virginia Commonwealth University, Richmond, Virginia.
  7. Department of Biostatistics, Virginia Commonwealth University, Richmond, Virginia.
  8. AbbVie, North Chicago, Illinois.
  9. Division of Oncology and Center for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. [email protected] [email protected].
  10. Philips Institute for Oral Health Research, VCU School of Dentistry and Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia. [email protected] [email protected].

PMID: 34088831 DOI: 10.1158/1535-7163.MCT-20-0710

Abstract

Venetoclax is a small molecule inhibitor of the prosurvival protein BCL-2 that has gained market approval in BCL-2-dependent hematologic cancers including chronic lymphocytic leukemia and acute myeloid leukemia. Neuroblastoma is a heterogenous pediatric cancer with a 5-year survival rate of less than 50% for high-risk patients, which includes nearly all cases with amplified

©2021 American Association for Cancer Research.

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