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Moreno-Mingorance A, Espinal P, Rodriguez V, et al. Circulation of multi-drug-resistant Shigella sonnei and Shigella flexneri among men who have sex with men in Barcelona, Spain, 2015-2019. Int J Antimicrob Agents. 2021;58(3):106378doi: 10.1016/j.ijantimicag.2021.106378.
Moreno-Mingorance, A., Espinal, P., Rodriguez, V., Goterris, L., Fàbrega, A., Serra-Pladevall, J., Barberà, M. J., Alberny, M., Martín-González, H., Cornejo-Sánchez, T., Armas, M., Mir-Cros, A., Raventós, A., Viñado, B., Pumarola, T., Larrosa, M. N., & González-López, J. J. (2021). Circulation of multi-drug-resistant Shigella sonnei and Shigella flexneri among men who have sex with men in Barcelona, Spain, 2015-2019. International journal of antimicrobial agents, 58(3), 106378. https://doi.org/10.1016/j.ijantimicag.2021.106378
Moreno-Mingorance, Albert, et al. "Circulation of multi-drug-resistant Shigella sonnei and Shigella flexneri among men who have sex with men in Barcelona, Spain, 2015-2019." International journal of antimicrobial agents vol. 58,3 (2021): 106378. doi: https://doi.org/10.1016/j.ijantimicag.2021.106378
Moreno-Mingorance A, Espinal P, Rodriguez V, Goterris L, Fàbrega A, Serra-Pladevall J, Barberà MJ, Alberny M, Martín-González H, Cornejo-Sánchez T, Armas M, Mir-Cros A, Raventós A, Viñado B, Pumarola T, Larrosa MN, González-López JJ. Circulation of multi-drug-resistant Shigella sonnei and Shigella flexneri among men who have sex with men in Barcelona, Spain, 2015-2019. Int J Antimicrob Agents. 2021 Sep;58(3):106378. doi: 10.1016/j.ijantimicag.2021.106378. Epub 2021 Jun 23. PMID: 34157402.
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Int J Antimicrob Agents. 2021 Sep;58(3):106378. doi: 10.1016/j.ijantimicag.2021.106378. Epub 2021 Jun 23.

Circulation of multi-drug-resistant Shigella sonnei and Shigella flexneri among men who have sex with men in Barcelona, Spain, 2015-2019.

International journal of antimicrobial agents

Albert Moreno-Mingorance, Paula Espinal, Virginia Rodriguez, Lidia Goterris, Anna Fàbrega, Judit Serra-Pladevall, M Jesús Barberà, Mireia Alberny, Héctor Martín-González, Thais Cornejo-Sánchez, Mayuli Armas, Alba Mir-Cros, Alex Raventós, Belén Viñado, Tomàs Pumarola, M Nieves Larrosa, Juan José González-López

Affiliations

  1. Vall d'Hebron Institut de Recerca, Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain; Department of Genetics and Microbiology, Universitat Autònoma de Barcelona, Barcelona, Spain.
  2. Vall d'Hebron Institut de Recerca, Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.
  3. Vall d'Hebron Institut de Recerca, Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain; Department of Clinical Microbiology, Vall d'Hebron Hospital Universitari, Barcelona, Spain.
  4. Drassanes-Vall d'Hebron Sexually Transmitted Infections Unit, Vall d'Hebron Hospital Universitari, Barcelona, Spain.
  5. Primary Healthcare Division, Catalan Institute of Health, Barcelona, Spain.
  6. Department of Clinical Microbiology, Vall d'Hebron Hospital Universitari, Barcelona, Spain.
  7. Department of Genetics and Microbiology, Universitat Autònoma de Barcelona, Barcelona, Spain.
  8. Vall d'Hebron Institut de Recerca, Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain; Department of Genetics and Microbiology, Universitat Autònoma de Barcelona, Barcelona, Spain; Department of Clinical Microbiology, Vall d'Hebron Hospital Universitari, Barcelona, Spain.
  9. Vall d'Hebron Institut de Recerca, Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain; Department of Genetics and Microbiology, Universitat Autònoma de Barcelona, Barcelona, Spain; Department of Clinical Microbiology, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Electronic address: [email protected].
  10. Vall d'Hebron Institut de Recerca, Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain; Department of Genetics and Microbiology, Universitat Autònoma de Barcelona, Barcelona, Spain; Department of Clinical Microbiology, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Electronic address: [email protected].

PMID: 34157402 DOI: 10.1016/j.ijantimicag.2021.106378

Abstract

BACKGROUND: In high-income countries, shigellosis is mainly found in travellers to high-risk regions or in men who have sex with men (MSM). This study investigated the genomic characteristics and the features of antimicrobial resistance of MSM-associated Shigella flexneri and Shigella sonnei circulating in Barcelona, Spain, elucidating their connectivity with contemporaneous Shigella spp. from other countries.

METHODS: Antimicrobial susceptibility, whole-genome sequencing, genomic characterization and phylogenetic analysis were performed in MSM-associated Shigella spp. recovered from 2015 to 2019. Reference genomes of MSM-associated Shigella spp. were included for contextualization and to determine their connection with international outbreaks.

RESULTS: In total, 44 S. flexneri and 26 S. sonnei were identified among MSM. Overall, 80% showed resistance to azithromycin, 65.7% showed resistance to trimethoprim-sulphamethoxazole and 32.8% showed resistance to ciprofloxacin; 27.1% were resistant to all three antimicrobials. mphA and/or ermB, and qnrS and mutations in the quinolone resistance determining regions were found in the azithromycin- and ciprofloxacin-resistant isolates, respectively. Additionally, two isolates carried bla

CONCLUSIONS: This study investigated the circulation of lineages of S. flexneri and S. sonnei among MSM in Spain that were mainly resistant to first-/second-line oral treatments, and closely related to dominant MSM-associated lineages described previously in the UK and Australia. These data reinforce the urgent need for the implementation of public health measures focusing on the early detection and prevention of transmission of this emerging pathogen, which is contributing to the antimicrobial resistance crisis in sexually transmitted infections.

Copyright © 2021 Elsevier Ltd. All rights reserved.

Keywords: Azithromycin resistance; MSM; Sexually transmitted infections; Shigellosis; Whole-genome sequencing

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