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Simkhada N, Adhikari P, Pathak BD, et al. A Rare Case of Subacute Sclerosing Panencephalitis Presenting As Generalized Seizure. Cureus. 2021;13(5):e15100doi: 10.7759/cureus.15100.
Simkhada, N., Adhikari, P., Pathak, B. D., Dhakal, B., & Mahat, K. (2021). A Rare Case of Subacute Sclerosing Panencephalitis Presenting As Generalized Seizure. Cureus, 13(5), e15100. https://doi.org/10.7759/cureus.15100
Simkhada, Nabin, et al. "A Rare Case of Subacute Sclerosing Panencephalitis Presenting As Generalized Seizure." Cureus vol. 13,5 (2021): e15100. doi: https://doi.org/10.7759/cureus.15100
Simkhada N, Adhikari P, Pathak BD, Dhakal B, Mahat K. A Rare Case of Subacute Sclerosing Panencephalitis Presenting As Generalized Seizure. Cureus. 2021 May 18;13(5):e15100. doi: 10.7759/cureus.15100. PMID: 34159008; PMCID: PMC8212923.
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Cureus. 2021 May 18;13(5):e15100. doi: 10.7759/cureus.15100.

A Rare Case of Subacute Sclerosing Panencephalitis Presenting As Generalized Seizure.

Cureus

Nabin Simkhada, Prakash Adhikari, Bishnu D Pathak, Bishal Dhakal, Krish Mahat

Affiliations

  1. Internal Medicine, Nepalese Army Institute of Health Sciences, Kathmandu, NPL.
  2. Internal Medicine, Piedmont Athens Regional Medical Center, Athens, USA.
  3. Internal Medicine, Shree Birendra Hospital, Kathmandu, NPL.

PMID: 34159008 PMCID: PMC8212923 DOI: 10.7759/cureus.15100

Abstract

Subacute sclerosing panencephalitis (SSPE) is a late complication of childhood measles. It is characterized by a progressive decline in cognitive and motor functions, seizures, and eventually death. Although a combination of intrathecal interferon alpha (IFN-α) and daily oral isoprinosine has been reported to have a good outcome, there is no cure for this condition.  We present a case of a 16-year-old male with SSPE who presented with progressive weakness, frequent loss of postural control, multiple episodes of generalized tonic-clonic seizures, and urinary incontinence. On exploration of his history, he had measles at the age of two months. Investigation showed increased serum measles antibody titer, high amplitude spikes in electroencephalogram (EEG), and high fluid-attenuated inversion recovery (FLAIR) signals on MRI of the brain consistent with probable SSPE. He was managed symptomatically until his condition got worse and he eventually passed away.

Copyright © 2021, Simkhada et al.

Keywords: adult onset sspe; measles complication; measles virus infection; sspe; subacute sclerosing panencephalitis

Conflict of interest statement

The authors have declared that no competing interests exist.

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