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Virus Evol. 2020 Jun 30;6(2):veaa047. doi: 10.1093/ve/veaa047. eCollection 2020 Jul.

Dual infection and recombination of Kaposi sarcoma herpesvirus revealed by whole-genome sequence analysis of effusion samples.

Virus evolution

Elena M Cornejo Castro, Vickie Marshall, Justin Lack, Kathryn Lurain, Taina Immonen, Nazzarena Labo, Nicholas C Fisher, Ramya Ramaswami, Mark N Polizzotto, Brandon F Keele, Robert Yarchoan, Thomas S Uldrick, Denise Whitby

Affiliations

  1. Viral Oncology Section, AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, P.O. Box B, Frederick, MD 21702, USA.
  2. Advanced Biomedical Computing Center, Leidos Biomedical Research, Inc., Frederick, MD 21702, USA.
  3. HIV and AIDS Malignancy Branch, National Cancer Institute, 10 Center Dr, Bethesda, MD 20814, USA.
  4. Retroviral Evolution Section, AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, P.O. Box B, Frederick, MD 21702, USA.

PMID: 34211736 PMCID: PMC7474928 DOI: 10.1093/ve/veaa047

Abstract

Kaposi sarcoma herpesvirus (KSHV) is the etiological agent of three malignancies, Kaposi sarcoma (KS), primary effusion lymphoma (PEL) and KSHV-associated multicentric Castelman disease. KSHV infected patients may also have an interleukin six-related KSHV-associated inflammatory cytokine syndrome. KSHV-associated diseases occur in only a minority of chronically KSHV-infected individuals and often in the setting of immunosuppression. Mechanisms by which KSHV genomic variations and systemic co-infections may affect the pathogenic pathways potentially leading to these diseases have not been well characterized

Published by Oxford University Press 2020. This work is written by US Government employees and is in the public domain in the US.

Keywords: KSHV; genetic diversity; recombination; virology; virus taxonomy

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