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Sun Y, Patel A, SantaLucia J, et al. Measurement of Klebsiella Intestinal Colonization Density To Assess Infection Risk. mSphere. 2021;6(3):e0050021doi: 10.1128/mSphere.00500-21.
Sun, Y., Patel, A., SantaLucia, J., Roberts, E., Zhao, L., Kaye, K., Rao, K., & Bachman, M. A. (2021). Measurement of Klebsiella Intestinal Colonization Density To Assess Infection Risk. mSphere, 6(3), e0050021. https://doi.org/10.1128/mSphere.00500-21
Sun, Yuang, et al. "Measurement of Klebsiella Intestinal Colonization Density To Assess Infection Risk." mSphere vol. 6,3 (2021): e0050021. doi: https://doi.org/10.1128/mSphere.00500-21
Sun Y, Patel A, SantaLucia J, Roberts E, Zhao L, Kaye K, Rao K, Bachman MA. Measurement of Klebsiella Intestinal Colonization Density To Assess Infection Risk. mSphere. 2021 Jun 30;6(3):e0050021. doi: 10.1128/mSphere.00500-21. Epub 2021 Jun 23. PMID: 34160234; PMCID: PMC8265666.
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mSphere. 2021 Jun 30;6(3):e0050021. doi: 10.1128/mSphere.00500-21. Epub 2021 Jun 23.

Measurement of Klebsiella Intestinal Colonization Density To Assess Infection Risk.

mSphere

Yuang Sun, Alieysa Patel, John SantaLucia, Emily Roberts, Lili Zhao, Keith Kaye, Krishna Rao, Michael A Bachman

Affiliations

  1. Department of Pathology, University of Michigan Medical School, Michigan Medicine, Ann Arbor, Michigan, USA.
  2. DNA Software, Inc., Plymouth, Michigan, USA.
  3. Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
  4. Division of Infectious Diseases, Department of Internal Medicine, University of Michigan Medical School, Michigan Medicine, Ann Arbor, Michigan, USA.
  5. Department of Microbiology and Immunology, University of Michigan Medical School, Michigan Medicine, Ann Arbor, Michigan, USA.

PMID: 34160234 PMCID: PMC8265666 DOI: 10.1128/mSphere.00500-21

Abstract

Klebsiella pneumoniae and the closely related species K. variicola and K. quasipneumoniae are common causes of health care-associated infections, and patients frequently become infected with their intestinal colonizing strain. To assess the association between Klebsiella colonization density and subsequent infections, a case-control study was performed. A multiplex quantitative PCR (qPCR) assay was developed and validated to quantify Klebsiella (K. pneumoniae,

Keywords: Klebsiella; dominance; infection risk; intestinal colonization; microbiome; qPCR

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