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Rao K, Patel A, Sun Y, et al. Risk Factors for Klebsiella Infections among Hospitalized Patients with Preexisting Colonization. mSphere. 2021;6(3):e0013221doi: 10.1128/mSphere.00132-21.
Rao, K., Patel, A., Sun, Y., Vornhagen, J., Motyka, J., Collingwood, A., Teodorescu, A., Baang, J. H., Zhao, L., Kaye, K. S., & Bachman, M. A. (2021). Risk Factors for Klebsiella Infections among Hospitalized Patients with Preexisting Colonization. mSphere, 6(3), e0013221. https://doi.org/10.1128/mSphere.00132-21
Rao, Krishna, et al. "Risk Factors for Klebsiella Infections among Hospitalized Patients with Preexisting Colonization." mSphere vol. 6,3 (2021): e0013221. doi: https://doi.org/10.1128/mSphere.00132-21
Rao K, Patel A, Sun Y, Vornhagen J, Motyka J, Collingwood A, Teodorescu A, Baang JH, Zhao L, Kaye KS, Bachman MA. Risk Factors for Klebsiella Infections among Hospitalized Patients with Preexisting Colonization. mSphere. 2021 Jun 30;6(3):e0013221. doi: 10.1128/mSphere.00132-21. Epub 2021 Jun 23. PMID: 34160237; PMCID: PMC8265626.
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mSphere. 2021 Jun 30;6(3):e0013221. doi: 10.1128/mSphere.00132-21. Epub 2021 Jun 23.

Risk Factors for Klebsiella Infections among Hospitalized Patients with Preexisting Colonization.

mSphere

Krishna Rao, Alieysa Patel, Yuang Sun, Jay Vornhagen, Jonathan Motyka, Abigail Collingwood, Alexandra Teodorescu, Ji Hoon Baang, Lili Zhao, Keith S Kaye, Michael A Bachman

Affiliations

  1. Division of Infectious Diseases, Department of Internal Medicine, University of Michigan Medical Schoolgrid.471406.0, Michigan Medicine, Ann Arbor, Michigan, USA.
  2. Department of Pathology, University of Michigan Medical Schoolgrid.471406.0, Michigan Medicine, Ann Arbor, Michigan, USA.
  3. Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
  4. Department of Microbiology and Immunology, University of Michigan Medical Schoolgrid.471406.0, Michigan Medicine, Ann Arbor, Michigan, USA.

PMID: 34160237 PMCID: PMC8265626 DOI: 10.1128/mSphere.00132-21

Abstract

Klebsiella commonly colonizes the intestinal tract of hospitalized patients and is a leading cause of health care-associated infections. Colonization is associated with subsequent infection, but the factors determining this progression are unclear. A cohort study was performed, in which intensive care and hematology/oncology patients with Klebsiella colonization based on rectal swab culture were enrolled and monitored for infection for 90 days after a positive swab. Electronic medical records were analyzed for patient factors associated with subsequent infection, and variables of potential significance in a bivariable analysis were used to build a final multivariable model. Concordance between colonizing and infecting isolates was assessed by

Keywords: Klebsiella; cohort study; infection risk; intestinal colonization; multivariable model

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