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Letzen JE, Robinson ML, Saletin JM, et al. Racial disparities in sleep-related cardiac function in young, healthy adults: implications for cardiovascular-related health. Sleep. 2021;44(11)doi: 10.1093/sleep/zsab164.
Letzen, J. E., Robinson, M. L., Saletin, J. M., Sheinberg, R. B., Smith, M. T., & Campbell, C. M. (2021). Racial disparities in sleep-related cardiac function in young, healthy adults: implications for cardiovascular-related health. Sleep, 44(11), . https://doi.org/10.1093/sleep/zsab164
Letzen, Janelle E, et al. "Racial disparities in sleep-related cardiac function in young, healthy adults: implications for cardiovascular-related health." Sleep vol. 44,11 (2021). doi: https://doi.org/10.1093/sleep/zsab164
Letzen JE, Robinson ML, Saletin JM, Sheinberg RB, Smith MT, Campbell CM. Racial disparities in sleep-related cardiac function in young, healthy adults: implications for cardiovascular-related health. Sleep. 2021 Nov 12;44(11). doi: 10.1093/sleep/zsab164. PMID: 34214173; PMCID: PMC8598177.
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Sleep. 2021 Nov 12;44(11). doi: 10.1093/sleep/zsab164.

Racial disparities in sleep-related cardiac function in young, healthy adults: implications for cardiovascular-related health.

Sleep

Janelle E Letzen, Mercedes L Robinson, Jared M Saletin, Rosanne B Sheinberg, Michael T Smith, Claudia M Campbell

Affiliations

  1. Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.
  2. Department of Neurology, School of Medicine, University of California, San Francisco, San Francisco, CA, USA.
  3. Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI, USA.
  4. Department of Anesthesiology and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.

PMID: 34214173 PMCID: PMC8598177 DOI: 10.1093/sleep/zsab164

Abstract

STUDY OBJECTIVES: Considerable evidence shows that individuals from marginalized racial/ethnic groups in the United States experience greater rates of sleep disturbance and cardiovascular complications. Because sleep is a modifiable factor that is critically involved in cardiovascular health, improved understanding of the association between sleep and cardiovascular health during early adulthood can prevent cardiovascular disparities. This study examined racial/ethnic differences in cardiovascular function during sleep using heart rate and heart-rate-variability analyses.

METHODS: Participants in this laboratory-based sleep study included healthy, "good sleepers" who were in early adulthood and resided in the United States at the time of participation (14 non-Hispanic Black [NHB; age = 30.9 (6.6), 57% female], 12 Asian [Asian, age = 26.0 (5.2), 42% female], and 24 non-Hispanic white [NHW; age = 24.6 (5.8), 79% female]).

RESULTS: After adjusting for demographic factors and an apnea-hypopnea index, we found significantly higher heart rate within NREM Stage 2 (N2) (b = -22.6, p = .04) and REM sleep (b = -25.8, p =.048) and lower heart rate variability during N2 sleep (b = -22.6, p = .04) among NHB individuals compared with NHW individuals. Furthermore, NHB and Asian participants demonstrated significantly lower percent of time in slow wave sleep (SWS) compared with NHW participants (NHB: b = -22.6, p =.04; Asian: b = -22.6, p = .04). Individuals' percent of time in SWS significantly mediated differences in heart rate during N2 (indirect = 0.94, 95% CI [0.03, 2.68]) and REM sleep (indirect = 1.02, 95% CI [0.04, 3.04]).

CONCLUSIONS: Our results showed disparities in sleep-related cardiovascular function in early adulthood that are mediated by SWS. These data suggest targeting sleep health in early adulthood might help reduce cardiovascular disease burden on individuals from marginalized groups.

© Sleep Research Society 2021. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please email: [email protected].

Keywords: SWS; cardiovascular health; heart rate variability; sleep disparities

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