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Yang MX, Shi K, Xu HY, et al. Inflammation in Remote Myocardium and Left Ventricular Remodeling After Acute Myocardial Infarction: A Pilot Study Using T2 Mapping. J Magn Reson Imaging. 2021;doi: 10.1002/jmri.27827.
Yang, M. X., Shi, K., Xu, H. Y., He, Y., Ma, M., Zhang, L., Wang, J. L., Li, X. S., Fu, C., Li, H., Zhou, B., Zhou, X. Y., Yang, Z., Guo, Y. K., & Yang, Z. G. (2021). Inflammation in Remote Myocardium and Left Ventricular Remodeling After Acute Myocardial Infarction: A Pilot Study Using T2 Mapping. Journal of magnetic resonance imaging : JMRI, . https://doi.org/10.1002/jmri.27827
Yang, Meng-Xi, et al. "Inflammation in Remote Myocardium and Left Ventricular Remodeling After Acute Myocardial Infarction: A Pilot Study Using T2 Mapping." Journal of magnetic resonance imaging : JMRI vol. (2021). doi: https://doi.org/10.1002/jmri.27827
Yang MX, Shi K, Xu HY, He Y, Ma M, Zhang L, Wang JL, Li XS, Fu C, Li H, Zhou B, Zhou XY, Yang Z, Guo YK, Yang ZG. Inflammation in Remote Myocardium and Left Ventricular Remodeling After Acute Myocardial Infarction: A Pilot Study Using T2 Mapping. J Magn Reson Imaging. 2021 Jul 09; doi: 10.1002/jmri.27827. Epub 2021 Jul 09. PMID: 34245075.
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J Magn Reson Imaging. 2021 Jul 09; doi: 10.1002/jmri.27827. Epub 2021 Jul 09.

Inflammation in Remote Myocardium and Left Ventricular Remodeling After Acute Myocardial Infarction: A Pilot Study Using T2 Mapping.

Journal of magnetic resonance imaging : JMRI

Meng-Xi Yang, Ke Shi, Hua-Yan Xu, Yong He, Min Ma, Lu Zhang, Jun-Long Wang, Xue-Sheng Li, Chuan Fu, Hong Li, Bin Zhou, Xiao-Yue Zhou, Zhi Yang, Ying-Kun Guo, Zhi-Gang Yang

Affiliations

  1. Department of Radiology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan, China.
  2. Department of Radiology, West China Hospital, Sichuan University, Sichuan, China.
  3. Department of Radiology, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Sichuan, China.
  4. Department of Cardiology, West China Hospital, Sichuan University, Sichuan, China.
  5. Department of Cardiology, The Sixth People's Hospital of Chengdu, Sichuan, China.
  6. Sichuan Greentech Bioscience Co Ltd, Sichuan, China.
  7. Department of Radiology, West China Second University Hospital, Sichuan University, Sichuan, China.
  8. Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Sichuan, China.
  9. MR Collaboration, Siemens Healthcare Ltd, Shanghai, China.
  10. Department of Radiology, Chengdu Fifth People's Hospital, Sichuan, China.

PMID: 34245075 DOI: 10.1002/jmri.27827

Abstract

BACKGROUND: The pathophysiological changes in the remote myocardium after acute myocardial infarction (MI) remains less understood.

PURPOSE: To assess the inflammation in the remote myocardium post-MI and its association with left ventricular (LV) remodeling using T2 mapping.

STUDY TYPE: Prospective.

ANIMAL MODEL AND SUBJECTS: Twelve pigs at 3-day post-MI, 6 pigs at 3-month post-MI, 6 healthy pigs; 54 patients at 3-day and 3-month post-MI, 31 healthy volunteers; FIELD STRENGTH/SEQUENCE: A 3 T MRI/ steady-state free-precession sequence for T2 mapping (animals: 0, 30, and 55 msec; human: 0, 25, and 55 msec), phase-sensitive inversion recovery gradient echo for late gadolinium enhancement (LGE), balanced steady free-precession sequence for cine.

ASSESSMENT: Infarcted myocardium was defined on LGE, remote T2 was measured on T2 maps. LV remodeling was evaluated as LV end-diastolic volume change index between two scans using cine. CD68 staining was conducted to detect monocyte/macrophage.

STATISTICAL TESTS: Student-t test and one-way ANOVA were used to compare remote T2 with normal controls. The association of remote T2 with LV remodeling was assessed using linear regression. P values of <0.05 were used to denote statistical significance.

RESULTS: Compared with healthy pigs, remote T2 significantly increased from 3 days to 3 months post-MI (31.43 ± 0.67 vs. 33.53 ± 1.15 vs. 36.43 ± 1.07 msec). CD68 staining demonstrated the inflammation in remote myocardium post-MI but not in healthy pigs. Significant remote myocardial alterations in T2 were also observed in human group (40.51 ± 1.79 vs. 41.94 ± 1.14 vs. 42.52 ± 1.71 msec). In patients, the 3-month remote T2 (β = 0.432) and remote T2 variation between two scans (β = 0.554) were both independently associated with LV remodeling.

CONCLUSION: T2 mapping could characterize the abnormalities in the remote myocardium post-MI, which was potentially caused by the inflammatory response. Moreover, variations in remote T2 were associated with LV remodeling.

EVIDENCE LEVEL: 1 TECHNICAL EFFICACY: Stage 3.

© 2021 International Society for Magnetic Resonance in Medicine.

Keywords: T2 mapping; acute myocardial infarction; inflammation; remote myocardium

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