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Wang J, Sun J, Wang Y, et al. Gold Nanoframeworks with Mesopores for Raman-Photoacoustic Imaging and Photo-Chemo Tumor Therapy in the Second Near-Infrared Biowindow. Adv Funct Mater. 2020;30(9)doi: 10.1002/adfm.201908825.
Wang, J., Sun, J., Wang, Y., Chou, T., Zhang, Q., Zhang, B., Ren, L., & Wang, H. (2020). Gold Nanoframeworks with Mesopores for Raman-Photoacoustic Imaging and Photo-Chemo Tumor Therapy in the Second Near-Infrared Biowindow. Advanced functional materials, 30(9), . https://doi.org/10.1002/adfm.201908825
Wang, Jinping, et al. "Gold Nanoframeworks with Mesopores for Raman-Photoacoustic Imaging and Photo-Chemo Tumor Therapy in the Second Near-Infrared Biowindow." Advanced functional materials vol. 30,9 (2020). doi: https://doi.org/10.1002/adfm.201908825
Wang J, Sun J, Wang Y, Chou T, Zhang Q, Zhang B, Ren L, Wang H. Gold Nanoframeworks with Mesopores for Raman-Photoacoustic Imaging and Photo-Chemo Tumor Therapy in the Second Near-Infrared Biowindow. Adv Funct Mater. 2020 Feb 26;30(9). doi: 10.1002/adfm.201908825. Epub 2020 Jan 08. PMID: 34163312; PMCID: PMC8218930.
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Adv Funct Mater. 2020 Feb 26;30(9). doi: 10.1002/adfm.201908825. Epub 2020 Jan 08.

Gold Nanoframeworks with Mesopores for Raman-Photoacoustic Imaging and Photo-Chemo Tumor Therapy in the Second Near-Infrared Biowindow.

Advanced functional materials

Jinping Wang, Jingyu Sun, Yuhao Wang, Tsengming Chou, Qiang Zhang, Beilu Zhang, Lei Ren, Hongjun Wang

Affiliations

  1. Department of Biomedical Engineering, Stevens Institute of Technology, Hoboken, NJ 07030, USA.
  2. Department of Chemistry and Chemical Biology, Stevens Institute of Technology, Hoboken, NJ 07030, USA.
  3. Laboratory for Multiscale Imaging, Stevens Institute of Technology, Hoboken, NJ 07030, USA.
  4. Department of Biomaterials, Key Laboratory of Biomedical Engineering of Fujian Province, State Key Lab of Physical Chemistry of Solid Surface, College of Materials, Xiamen University, Xiamen, Fujian 361005, P. R. China.

PMID: 34163312 PMCID: PMC8218930 DOI: 10.1002/adfm.201908825

Abstract

Gold-based nanostructures with tunable wavelength of localized surface plasmon resonance (LSPR) in the second near-infrared (NIR-II) biowindow receive increasing attention in phototheranostics. In view of limited progress on NIR-II gold nanostructures, a particular liposome template-guided route is explored to synthesize novel gold nanoframeworks (AuNFs) with large mesopores (≈40 nm) for multimodal imaging along with therapeutic robustness. The synthesized AuNFs exhibit strong absorbance in NIR-II region, affording their capacity of NIR-II photothermal therapy (PTT) and photoacoustic (PA) imaging for deep tumors. Functionalization of AuNFs with hyaluronic acid (HA) endows the targeting capacity for CD44-overexpressed tumor cells while gatekeeping doxorubicin (DOX) loaded into mesopores. Conjugation of Raman reporter 4-aminothiophenol (4-ATP) onto AuNFs yields a surface-enhanced Raman scattering (SERS) fingerprint for Raman spectroscopy/imaging. In vivo evaluation of HA-4-ATP-AuNFs-DOX on tumor-bearing xenografts demonstrates its high efficacy in eradication of solid tumors in NIR-II under PA-Raman dual image-guided photo-chemotherapy. Thus, current AuNFs offer versatile capabilities for phototheranostics.

Keywords: Raman imaging; chemotherapy; gold nanoframeworks; photoacoustic imaging; second near-infrared photothermal therapy

Conflict of interest statement

Conflict of Interest The authors declare no conflict of interest.

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