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Granato A, Merighi A. Dendrites of Neocortical Pyramidal Neurons: The Key to Understand Intellectual Disability. Cell Mol Neurobiol. 2021;doi: 10.1007/s10571-021-01123-1.
Granato, A., & Merighi, A. (2021). Dendrites of Neocortical Pyramidal Neurons: The Key to Understand Intellectual Disability. Cellular and molecular neurobiology, . https://doi.org/10.1007/s10571-021-01123-1
Granato, Alberto, and Merighi, Adalberto. "Dendrites of Neocortical Pyramidal Neurons: The Key to Understand Intellectual Disability." Cellular and molecular neurobiology vol. (2021). doi: https://doi.org/10.1007/s10571-021-01123-1
Granato A, Merighi A. Dendrites of Neocortical Pyramidal Neurons: The Key to Understand Intellectual Disability. Cell Mol Neurobiol. 2021 Jul 03; doi: 10.1007/s10571-021-01123-1. Epub 2021 Jul 03. PMID: 34216332.
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Cell Mol Neurobiol. 2021 Jul 03; doi: 10.1007/s10571-021-01123-1. Epub 2021 Jul 03.

Dendrites of Neocortical Pyramidal Neurons: The Key to Understand Intellectual Disability.

Cellular and molecular neurobiology

Alberto Granato, Adalberto Merighi

Affiliations

  1. Department of Veterinary Sciences, University of Turin, Largo Paolo Braccini 2, 10095, Grugliasco, TO, Italy. [email protected].
  2. Department of Veterinary Sciences, University of Turin, Largo Paolo Braccini 2, 10095, Grugliasco, TO, Italy.

PMID: 34216332 DOI: 10.1007/s10571-021-01123-1

Abstract

Pyramidal neurons (PNs) are the most abundant cells of the neocortex and display a vast dendritic tree, divided into basal and apical compartments. Morphological and functional anomalies of PN dendrites are at the basis of virtually all neurological and mental disorders, including intellectual disability. Here, we provide evidence that the cognitive deficits observed in different types of intellectual disability might be sustained by different parts of the PN dendritic tree, or by a dysregulation of their interaction.

Keywords: Apical dendrite; Calcium; Cerebral cortex; Dendritic spike; Down syndrome; Fetal alcohol

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