Display options
Share it on

Front Cell Dev Biol. 2021 Jun 25;9:693534. doi: 10.3389/fcell.2021.693534. eCollection 2021.

Biological Properties of Milk-Derived Extracellular Vesicles and Their Physiological Functions in Infant.

Frontiers in cell and developmental biology

Xue Jiang, Lianghui You, Zhenxing Zhang, Xianwei Cui, Hong Zhong, Xingzhen Sun, Chenbo Ji, Xia Chi

Affiliations

  1. Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China.
  2. The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian, China.
  3. The First Affiliated Hospital With Nanjing Medical University, Nanjing, China.

PMID: 34249944 PMCID: PMC8267587 DOI: 10.3389/fcell.2021.693534

Abstract

Extracellular vesicles (EVs) are released by all cells under pathological and physiological conditions. EVs harbor various biomolecules, including protein, lipid, non-coding RNA, messenger RNA, and DNA. In 2007, mRNA and microRNA (miRNA) carried by EVs were found to have regulatory functions in recipient cells. The biological function of EVs has since then increasingly drawn interest. Breast milk, as the most important nutritional source for infants, contains EVs in large quantities. An increasing number of studies have provided the basis for the hypothesis associated with information transmission between mothers and infants via breast milk-derived EVs. Most studies on milk-derived EVs currently focus on miRNAs. Milk-derived EVs contain diverse miRNAs, which remain stable both

Copyright © 2021 Jiang, You, Zhang, Cui, Zhong, Sun, Ji and Chi.

Keywords: exosome; extracellular vesicles; growth and development; infant; microRNA; milk

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

References

  1. Genome Res. 2009 Jan;19(1):92-105 - PubMed
  2. BMC Genomics. 2014 Nov 23;15:1012 - PubMed
  3. Bioact Mater. 2021 Feb 02;6(8):2479-2490 - PubMed
  4. Pediatr Res. 2017 Aug;82(2):226-236 - PubMed
  5. Mol Nutr Food Res. 2021 May;65(10):e2000845 - PubMed
  6. Int J Mol Sci. 2021 Jan 22;22(3): - PubMed
  7. J Agric Food Chem. 2019 Aug 28;67(34):9477-9491 - PubMed
  8. J Pediatr. 2013 Jul;163(1):49-54 - PubMed
  9. J Dairy Sci. 2019 Aug;102(8):6726-6737 - PubMed
  10. Sci Rep. 2015 May 22;5:9930 - PubMed
  11. Mol Nutr Food Res. 2017 Nov;61(11): - PubMed
  12. Development. 2010 Aug 1;137(15):2493-9 - PubMed
  13. Mol Ther Nucleic Acids. 2020 Oct 04;22:779-790 - PubMed
  14. J Anim Sci Biotechnol. 2021 Feb 3;12(1):12 - PubMed
  15. J Anim Physiol Anim Nutr (Berl). 2019 Jan;103(1):276-282 - PubMed
  16. RNA Biol. 2021 May;18(5):818-831 - PubMed
  17. Biochem Biophys Res Commun. 2011 Aug 12;411(4):826-31 - PubMed
  18. Nutrients. 2020 Aug 26;12(9): - PubMed
  19. J Pediatr Gastroenterol Nutr. 2011 Dec;53(6):606-14 - PubMed
  20. J Nutr. 2015 Oct;145(10):2201-6 - PubMed
  21. J Clin Invest. 2010 Feb;120(2):457-71 - PubMed
  22. Cell. 2009 Nov 13;139(4):693-706 - PubMed
  23. PLoS One. 2019 Jan 30;14(1):e0211431 - PubMed
  24. Theranostics. 2020 Jul 9;10(18):8197-8210 - PubMed
  25. Gene. 2020 Jun 15;743:144609 - PubMed
  26. Front Immunol. 2019 Oct 25;10:2543 - PubMed
  27. Innate Immun. 2018 Jul;24(5):278-284 - PubMed
  28. J Pediatr Surg. 2017 May;52(5):755-759 - PubMed
  29. Sci Rep. 2017 Jun 14;7(1):3507 - PubMed
  30. Pediatr Surg Int. 2019 Dec;35(12):1363-1368 - PubMed
  31. Sci Rep. 2019 Oct 10;9(1):14661 - PubMed
  32. Cell. 1983 Jul;33(3):967-78 - PubMed
  33. Med Hypotheses. 2015 Aug;85(2):141-4 - PubMed
  34. Br J Haematol. 1967 May;13(3):269-88 - PubMed
  35. Silence. 2010 Mar 01;1(1):7 - PubMed
  36. Mol Nutr Food Res. 2015 Sep;59(9):1701-12 - PubMed
  37. J Nutr. 2018 Dec 1;148(12):1886-1894 - PubMed
  38. J Biol Chem. 2010 Jun 4;285(23):17442-52 - PubMed
  39. J Intern Med. 2007 May;261(5):412-7 - PubMed
  40. Cell Res. 2012 Jan;22(1):107-26 - PubMed
  41. J Dairy Sci. 2020 Sep;103(9):7752-7760 - PubMed
  42. J Biol Chem. 1987 Jul 5;262(19):9412-20 - PubMed
  43. J Proteomics. 2012 Feb 16;75(5):1486-92 - PubMed
  44. Food Res Int. 2017 Feb;92:17-25 - PubMed
  45. Front Nutr. 2018 Sep 18;5:81 - PubMed
  46. J Agric Food Chem. 2017 Feb 15;65(6):1220-1228 - PubMed
  47. Mol Nutr Food Res. 2018 Jun;62(11):e1701050 - PubMed
  48. Nat Commun. 2017 May 16;8:15287 - PubMed
  49. J Nutr Biochem. 2018 Sep;59:123-128 - PubMed
  50. Sci Rep. 2021 Mar 12;11(1):5840 - PubMed
  51. Curr Opin Neurobiol. 2013 Dec;23(6):928-34 - PubMed
  52. J Extracell Vesicles. 2021 Mar;10(5):e12071 - PubMed
  53. Cell Metab. 2021 Apr 6;33(4):781-790.e5 - PubMed
  54. Food Chem. 2021 Jul 15;350:129142 - PubMed
  55. J Dairy Sci. 2015 May;98(5):2920-33 - PubMed
  56. Am J Physiol Gastrointest Liver Physiol. 2019 Nov 1;317(5):G618-G624 - PubMed
  57. BMC Vet Res. 2017 Apr 13;13(1):101 - PubMed
  58. J Extracell Vesicles. 2018 Feb 21;7(1):1440132 - PubMed
  59. J Pediatr Gastroenterol Nutr. 2019 Aug;69(2):235-238 - PubMed
  60. Diabetol Metab Syndr. 2020 Apr 15;12:32 - PubMed
  61. Biochem Pharmacol. 2020 May;175:113898 - PubMed
  62. Trends Cell Biol. 2015 Jun;25(6):364-72 - PubMed
  63. J Extracell Vesicles. 2017 Sep 3;6(1):1368823 - PubMed
  64. BMC Genomics. 2018 Nov 20;19(1):828 - PubMed
  65. Science. 2020 Feb 7;367(6478): - PubMed
  66. Prog Neurobiol. 2011 Oct;95(2):229-74 - PubMed
  67. Epigenetics. 2016 Oct 2;11(10):721-729 - PubMed
  68. Mol Cell Proteomics. 2017 Aug;16(8):1547 - PubMed
  69. Eur J Pharm Biopharm. 2021 Jan;158:198-210 - PubMed
  70. Sci Rep. 2020 Apr 24;10(1):6983 - PubMed
  71. Sci Rep. 2018 Jul 27;8(1):11321 - PubMed
  72. Cell Res. 2010 Oct;20(10):1128-37 - PubMed
  73. Food Funct. 2020 Mar 26;11(3):2154-2162 - PubMed
  74. BMC Genomics. 2015 Oct 16;16:806 - PubMed
  75. Protein Cell. 2013 Mar;4(3):197-210 - PubMed
  76. Epigenetics. 2021 Apr;16(4):389-404 - PubMed
  77. Mol Nutr Food Res. 2017 Oct;61(10): - PubMed
  78. J Immunol. 2007 Aug 1;179(3):1969-78 - PubMed
  79. J Pediatr Surg. 2020 Jan;55(1):54-58 - PubMed
  80. PLoS Biol. 2020 Feb 24;18(2):e3000603 - PubMed
  81. Nat Cell Biol. 2007 Jun;9(6):654-9 - PubMed
  82. Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6328-33 - PubMed
  83. Cancer Lett. 2021 May 1;505:58-72 - PubMed
  84. AIDS. 2014 Jan 14;28(2):171-80 - PubMed
  85. Mol Cell Proteomics. 2016 Nov;15(11):3412-3423 - PubMed
  86. Life Sci. 2021 Jun 1;274:119249 - PubMed
  87. Lancet. 1984 Nov 10;2(8411):1083-6 - PubMed
  88. Lancet. 2016 Jan 30;387(10017):475-90 - PubMed
  89. Nestle Nutr Inst Workshop Ser. 2019;90:83-92 - PubMed
  90. J Agric Food Chem. 2015 Jan 21;63(2):588-92 - PubMed
  91. J Dev Orig Health Dis. 2020 Oct;11(5):441-451 - PubMed
  92. Front Genet. 2020 Jul 02;11:652 - PubMed
  93. Front Immunol. 2018 Feb 28;9:361 - PubMed
  94. Int J Biol Sci. 2012;8(1):118-23 - PubMed
  95. Inflamm Intest Dis. 2020 Aug;5(3):117-123 - PubMed
  96. Adv Nutr. 2021 Jun 1;12(3):1006-1019 - PubMed
  97. J Extracell Vesicles. 2018 Nov 23;7(1):1535750 - PubMed
  98. J Nutr. 2021 Jun 1;151(6):1416-1425 - PubMed
  99. Curr Dev Nutr. 2019 Oct 31;3(12):nzz122 - PubMed
  100. Nat Commun. 2021 Jan 11;12(1):213 - PubMed
  101. J Nutr. 2017 Jan;147(1):3-10 - PubMed
  102. Am J Physiol Cell Physiol. 2016 May 15;310(10):C800-7 - PubMed
  103. Nat Immunol. 2016 Apr;17(4):433-40 - PubMed
  104. Cancer Lett. 2019 May 1;449:186-195 - PubMed
  105. Allergy. 2014 Apr;69(4):463-71 - PubMed
  106. J Exp Med. 1996 Mar 1;183(3):1161-72 - PubMed
  107. J Dairy Sci. 2018 Apr;101(4):2932-2940 - PubMed
  108. Biochem Biophys Res Commun. 2018 Jun 7;500(3):577-582 - PubMed
  109. Annu Rev Cell Dev Biol. 2014;30:255-89 - PubMed
  110. Cell. 2017 Oct 5;171(2):372-384.e12 - PubMed
  111. Cancer Lett. 2016 Feb 1;371(1):48-61 - PubMed
  112. Diabetes. 2009 Nov;58(11):2498-505 - PubMed
  113. J Allergy Clin Immunol. 2010 Nov;126(5):1032-40, 1040.e1-4 - PubMed
  114. Mol Nutr Food Res. 2019 May 8;:e1801247 - PubMed
  115. Microorganisms. 2020 Jul 21;8(7): - PubMed
  116. Diabetes Obes Metab. 2017 Sep;19 Suppl 1:137-146 - PubMed
  117. Mol Cell. 2010 Jul 9;39(1):133-44 - PubMed
  118. J Extracell Vesicles. 2014 Aug 14;3: - PubMed
  119. Mol Cancer. 2020 Jul 27;19(1):117 - PubMed

Publication Types