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Scudeletti M, Lanza L, Contini P, et al. Modulation of MHC Gene Expression by Glucocorticoid Hormones. Int Arch Allergy Immunol. 2009;99(2):295-301doi: 10.1159/000236268.
Scudeletti, M., Lanza, L., Contini, P., Puppo, F., & Indiveri, F. (1992). Modulation of MHC Gene Expression by Glucocorticoid Hormones. International archives of allergy and immunology, 99(2), 295-301. https://doi.org/10.1159/000236268
Scudeletti, M, et al. "Modulation of MHC Gene Expression by Glucocorticoid Hormones." International archives of allergy and immunology vol. 99,2 (1992): 295-301. doi: https://doi.org/10.1159/000236268
Scudeletti M, Lanza L, Contini P, Puppo F, Indiveri F. Modulation of MHC Gene Expression by Glucocorticoid Hormones. Int Arch Allergy Immunol. 1992;99(2):295-301. doi: 10.1159/000236268. Epub 2009 Sep 02. PMID: 34167222.
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Int Arch Allergy Immunol. 1992;99(2):295-301. doi: 10.1159/000236268. Epub 2009 Sep 02.

Modulation of MHC Gene Expression by Glucocorticoid Hormones.

International archives of allergy and immunology

M Scudeletti, L Lanza, P Contini, F Puppo, F Indiveri

PMID: 34167222 DOI: 10.1159/000236268

Abstract

The effects of the glucocorticoid hormones prednisone (PDN) and deflazacort (DFC) on MHC gene products membrane expression and mRNA level were evaluated on peripheral blood lymphocytes and on the melanoma M14 cell line. The modulatory effect of the association of PDN and DFC with interferon-γ was also evaluated. PDN and DFC inhibited MHC gene expression in lymphocytes and M14 cells both on the cell membrane and at the mRNA level. Interferon-γ was able to counteract this inhibitory effect. These results may contribute to clarify the role played by glucocorticoid hormones in the modulation of immune responses.

© 1992 S. Karger AG, Basel.

Keywords: Glucocorticoids; HLA; Interferon; Lymphocytes; MHC; Melanoma

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