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Glovsky MM, Farrow N, Ross B, et al. Hypoxic and Complement-Induced Lung Injury in the Isolated Perfused Rat Lung as Determined by Phosphorous-31 Nuclear Magnetic Resonance. Int Arch Allergy Immunol. 2009;99(2):429-434doi: 10.1159/000236304.
Glovsky, M. M., Farrow, N., Ross, B., Ward, P. A., & Morganroth, M. (1992). Hypoxic and Complement-Induced Lung Injury in the Isolated Perfused Rat Lung as Determined by Phosphorous-31 Nuclear Magnetic Resonance. International archives of allergy and immunology, 99(2), 429-434. https://doi.org/10.1159/000236304
Glovsky, M M, et al. "Hypoxic and Complement-Induced Lung Injury in the Isolated Perfused Rat Lung as Determined by Phosphorous-31 Nuclear Magnetic Resonance." International archives of allergy and immunology vol. 99,2 (1992): 429-434. doi: https://doi.org/10.1159/000236304
Glovsky MM, Farrow N, Ross B, Ward PA, Morganroth M. Hypoxic and Complement-Induced Lung Injury in the Isolated Perfused Rat Lung as Determined by Phosphorous-31 Nuclear Magnetic Resonance. Int Arch Allergy Immunol. 1992;99(2):429-434. doi: 10.1159/000236304. Epub 2009 Sep 02. PMID: 34167264.
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Int Arch Allergy Immunol. 1992;99(2):429-434. doi: 10.1159/000236304. Epub 2009 Sep 02.

Hypoxic and Complement-Induced Lung Injury in the Isolated Perfused Rat Lung as Determined by Phosphorous-31 Nuclear Magnetic Resonance.

International archives of allergy and immunology

M M Glovsky, N Farrow, B Ross, P A Ward, M Morganroth

PMID: 34167264 DOI: 10.1159/000236304

Abstract

Magnetic resonance spectroscopy (MRS) is a non-invasive method of obtaining biochemical information. Patients or experimental animals are placed within a magnetic imaging device and specific patterns of chemical spectra, such as P31 patterns of adenosine triphosphate (ATP) can be recorded. We have injured the isolated rat lung by complement activation and hypoxia. Nuclear magnetic resonance patterns of phosphate metabolites revealed markedly diminished lung concentrations of ATP and phosphocreatine. In vivo measurement of lung metabolism through MRS may be a useful tool to measure metabolism of severe lung disease in man.

© 1992 S. Karger AG, Basel.

Keywords: Complement; Lung Injury; P-31-NMR

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