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Lee H, Zhuang L, Gan B. Ether phospholipids govern ferroptosis. J Genet Genomics. 2021;48(7):517-519doi: 10.1016/j.jgg.2021.05.003.
Lee, H., Zhuang, L., & Gan, B. (2021). Ether phospholipids govern ferroptosis. Journal of genetics and genomics = Yi chuan xue bao, 48(7), 517-519. https://doi.org/10.1016/j.jgg.2021.05.003
Lee, Hyemin, et al. "Ether phospholipids govern ferroptosis." Journal of genetics and genomics = Yi chuan xue bao vol. 48,7 (2021): 517-519. doi: https://doi.org/10.1016/j.jgg.2021.05.003
Lee H, Zhuang L, Gan B. Ether phospholipids govern ferroptosis. J Genet Genomics. 2021 Jul 20;48(7):517-519. doi: 10.1016/j.jgg.2021.05.003. Epub 2021 Jun 01. PMID: 34167916; PMCID: PMC8453040.
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J Genet Genomics. 2021 Jul 20;48(7):517-519. doi: 10.1016/j.jgg.2021.05.003. Epub 2021 Jun 01.

Ether phospholipids govern ferroptosis.

Journal of genetics and genomics = Yi chuan xue bao

Hyemin Lee, Li Zhuang, Boyi Gan

Affiliations

  1. Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  2. Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; The University of Texas MD Anderson UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA. Electronic address: [email protected].

PMID: 34167916 PMCID: PMC8453040 DOI: 10.1016/j.jgg.2021.05.003

Abstract

Ferroptosis is a cell death modality triggered by excessive lipid peroxidation. Two recent studies (Zou et al., 2020; Cui et al., 2021) not only reveal critical roles of ether-linked phospholipids as an additional source for providing polyunsaturated fatty acid-containing phospholipids in driving ferroptosis but also suggest a context-dependent role of TMEM189-mediated vinyl-ether phospholipid (plasmalogen) synthesis in ferroptosis.

Copyright © 2021 Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Ltd. All rights reserved.

Keywords: Ether phospholipids; Ferroptosis; Lipid peroxidation; Plasmalogen; TMEM189

Conflict of interest statement

Conflict of interest Boyi Gan is an inventor on patent applications involving targeting ferroptosis in cancer therapy. The other authors declare no competing interests.

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