J Parkinsons Dis. 2021;11(4):1507-1535. doi: 10.3233/JPD-212605.
Oral Health Disorders in Parkinson's Disease: More than Meets the Eye.
Journal of Parkinson's disease
Manon Auffret, Vincent Meuric, Emile Boyer, Martine Bonnaure-Mallet, Marc Vérin
Affiliations
Affiliations
- Behavior & Basal Ganglia Research Unit (EA 4712), University of Rennes 1, Rennes, France.
- Institut des Neurosciences Cliniques de Rennes (INCR), Rennes, France.
- INSERM, INRAE, Université de Rennes 1, CHU de Rennes, Nutrition Metabolisms and Cancer, Rennes, France.
- Movement Disorders Unit, Neurology Department, Pontchaillou University Hospital, Rennes, France.
PMID: 34250950
PMCID: PMC8609694 DOI: 10.3233/JPD-212605
Abstract
Despite clinical evidence of poor oral health and hygiene in Parkinson's disease (PD) patients, the mouth is often overlooked by both patients and the medical community, who generally focus on motor or psychiatric disorders considered more burdensome. Yet, oral health is in a two-way relationship with overall health-a weakened status triggering a decline in the quality of life. Here, we aim at giving a comprehensive overview of oral health disorders in PD, while identifying their etiologies and consequences. The physical (abnormal posture, muscle tone, tremor, and dyskinesia), behavioral (cognitive and neuropsychiatric disorders), and iatrogenic patterns associated with PD have an overall detrimental effect on patients' oral health, putting them at risk for other disorders (infections, aspiration, pain, malnutrition), reducing their quality of life and increasing their isolation (anxiety, depression, communication issues). Interdisciplinary cooperation for prevention, management and follow-up strategies need to be implemented at an early stage to maintain and improve patients' overall comfort and condition. Recommendations for practice, including (non-)pharmacological management strategies are discussed, with an emphasis on the neurologists' role. Of interest, the oral cavity may become a valuable tool for diagnosis and prognosis in the near future (biomarkers). This overlooked but critical issue requires further attention and interdisciplinary research.
Keywords: Parkinson’s disease; dentistry; interdisciplinary research; microbiota; oral health; stomatognathic diseases
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