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Hignett SM, Judd O. Frey's syndrome: A review of the physiology and possible role of neurotrophic factors. Laryngoscope Investig Otolaryngol. 2021;6(3):420-424doi: 10.1002/lio2.559.
Hignett, S. M., & Judd, O. (2021). Frey's syndrome: A review of the physiology and possible role of neurotrophic factors. Laryngoscope investigative otolaryngology, 6(3), 420-424. https://doi.org/10.1002/lio2.559
Hignett, Sarah M, and Judd, Owen. "Frey's syndrome: A review of the physiology and possible role of neurotrophic factors." Laryngoscope investigative otolaryngology vol. 6,3 (2021): 420-424. doi: https://doi.org/10.1002/lio2.559
Hignett SM, Judd O. Frey's syndrome: A review of the physiology and possible role of neurotrophic factors. Laryngoscope Investig Otolaryngol. 2021 Apr 08;6(3):420-424. doi: 10.1002/lio2.559. eCollection 2021 Jun. PMID: 34195362; PMCID: PMC8223467.
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Laryngoscope Investig Otolaryngol. 2021 Apr 08;6(3):420-424. doi: 10.1002/lio2.559. eCollection 2021 Jun.

Frey's syndrome: A review of the physiology and possible role of neurotrophic factors.

Laryngoscope investigative otolaryngology

Sarah M Hignett, Owen Judd

Affiliations

  1. School of Medicine University of Leeds Leeds UK.
  2. Department of Otolaryngology Royal Derby Hospital Derby UK.

PMID: 34195362 PMCID: PMC8223467 DOI: 10.1002/lio2.559

Abstract

OBJECTIVES: Frey's syndrome (FS) describes the phenomenon of gustatory sweating and is a cause of significant social embarrassment for sufferers. It has been attributed to aberrant growth of parasympathetic salivatory fibers in the auriculotemporal nerve toward overlying sweat glands. However, the exact mechanism behind this growth is unknown. This review aims to expand and elucidate the theory of aberrant regeneration in FS.

METHODS: A review of the recent literature on nerve regeneration was conducted in order develop further insights into the etiology of both adult onset and pediatric FS.

RESULTS: Neurturin, a neurotrophic factor released by both salivary and sweat glands, was identified as a possible key player in the etiology of FS.

CONCLUSION: Further research into the role of neurturin could help to elucidate the pathogenic mechanisms underlying the condition and might reveal neurturin to be a potential target for pharmacological intervention.

LEVEL OF EVIDENCE: NA (Basic Science Review).

© 2021 The Authors. Laryngoscope Investigative Otolaryngology published by Wiley Periodicals LLC on behalf of The Triological Society.

Keywords: Frey's syndrome; auriculotemporal nerve; neurology; neurotrophic factor; neurturin

Conflict of interest statement

There are no conflicts of interest to declare.

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