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Fatahi S, Sohouli MH, Rayi A, et al. The association between food insulin index and odds of non-alcoholic fatty liver disease (NAFLD) in adults: a case-control study. Gastroenterol Hepatol Bed Bench. 2021;14(3):221-228
Fatahi, S., Sohouli, M. H., Rayi, A., Teymoori, F., & Shidfar, F. (2021). The association between food insulin index and odds of non-alcoholic fatty liver disease (NAFLD) in adults: a case-control study. Gastroenterology and hepatology from bed to bench, 14(3), 221-228.
Fatahi, Somaye, et al. "The association between food insulin index and odds of non-alcoholic fatty liver disease (NAFLD) in adults: a case-control study." Gastroenterology and hepatology from bed to bench vol. 14,3 (2021): 221-228.
Fatahi S, Sohouli MH, Rayi A, Teymoori F, Shidfar F. The association between food insulin index and odds of non-alcoholic fatty liver disease (NAFLD) in adults: a case-control study. Gastroenterol Hepatol Bed Bench. 2021;14(3):221-228. PMID: 34221261; PMCID: PMC8245830.
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Gastroenterol Hepatol Bed Bench. 2021;14(3):221-228.

The association between food insulin index and odds of non-alcoholic fatty liver disease (NAFLD) in adults: a case-control study.

Gastroenterology and hepatology from bed to bench

Somaye Fatahi, Mohammad Hassan Sohouli, Appaji Rayi, Farshad Teymoori, Farzad Shidfar

Affiliations

  1. Student Research Committee, Iran University of Medical Sciences, Tehran, Iran.
  2. Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
  3. Department of Neurology, Charleston Area Medical Center, Charleston, WV, USA.
  4. Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

PMID: 34221261 PMCID: PMC8245830

Abstract

AIM: This research aimed to study the association of food insulin index and biochemical parameters with the

BACKGROUND: Hyperinsulinemia may play an important role in the development of non-alcoholic fatty liver disease (NAFLD) because of the relationship between insulin response and body fat accumulation.

METHODS: A case-control study of 169 NAFLD patients and 200 healthy adults aged 18-55 years was conducted. Dietary data was collected using a validated 168-item quantitative food frequency questionnaire (FFQ). Food insulin index (FII) was calculated by dividing the total insulin load by total energy intake (kcal/day). Total insulin load (ILoverall) was also calculated using a standard formula.

RESULTS: Mean participant age was 43.9 ± 5.9 years. Patients with NAFLD were significantly associated with higher body mass index, levels of liver enzymes, triglyceride, low density lipoprotein-cholesterol (LDL), total cholesterol, and fasting blood sugar (FBS) compared to the healthy subjects (

CONCLUSION: This study found that adherence to a diet with high FII was associated with greater odds of NAFLD and overweight or obesity. Additional studies are required to better understand this association.

©2021 RIGLD, Research Institute for Gastroenterology and Liver Diseases.

Keywords: Biochemical processes; Chronic diseases; Insulin; Non-alcoholic fatty liver disease; Obesity

Conflict of interest statement

The authors declare that they have no conflict of interest.

References

  1. World J Diabetes. 2020 May 15;11(5):193-201 - PubMed
  2. Indian J Clin Biochem. 2008 Apr;23(2):130-5 - PubMed
  3. Nutrients. 2013 May 10;5(5):1544-60 - PubMed
  4. Am J Clin Nutr. 1997 Nov;66(5):1264-76 - PubMed
  5. Expert Rev Gastroenterol Hepatol. 2016;10(2):229-42 - PubMed
  6. Diabetes Care. 2011 Oct;34(10):2146-51 - PubMed
  7. Nature. 2006 Dec 14;444(7121):840-6 - PubMed
  8. Lancet Diabetes Endocrinol. 2014 Nov;2(11):901-10 - PubMed
  9. Am J Clin Nutr. 2011 Sep;94(3):862-8 - PubMed
  10. Atherosclerosis. 2015 Mar;239(1):192-202 - PubMed
  11. Metabolism. 2016 Aug;65(8):1080-6 - PubMed
  12. Diabetes Technol Ther. 2016 Apr;18(4):218-25 - PubMed
  13. BMC Fam Pract. 2015 Sep 02;16:113 - PubMed
  14. Curr Opin Gastroenterol. 2013 Mar;29(2):222-7 - PubMed
  15. Eur J Nutr. 2020 Jun;59(4):1563-1575 - PubMed
  16. Cancer Epidemiol Biomarkers Prev. 2010 Dec;19(12):3020-6 - PubMed
  17. Diabetes Care. 2008 Dec;31(12):2281-3 - PubMed
  18. Nutrients. 2016 Apr 08;8(4):210 - PubMed
  19. Nutrition. 2015 May;31(5):697-702 - PubMed
  20. Int J Mol Sci. 2016 Apr 27;17(5): - PubMed
  21. J Nutr. 2019 May 1;149(5):804-815 - PubMed
  22. Nutr Neurosci. 2021 May;24(5):354-362 - PubMed
  23. J Acad Nutr Diet. 2020 Oct;120(10):1672-1686.e4 - PubMed
  24. Am J Clin Nutr. 2011 Jul;94(1):182-90 - PubMed
  25. J Formos Med Assoc. 2021 Feb;120(2):794-803 - PubMed
  26. Metabolites. 2020 May 14;10(5): - PubMed
  27. Am J Clin Nutr. 2009 Oct;90(4):986-92 - PubMed
  28. JAMA Pediatr. 2014 Apr;168(4):338-344 - PubMed
  29. J Hepatol. 2012 Jan;56(1):255-66 - PubMed
  30. Am J Epidemiol. 1985 Jul;122(1):51-65 - PubMed
  31. J Hepatol. 2020 Aug;73(2):263-276 - PubMed
  32. PLoS One. 2015 Oct 29;10(10):e0140908 - PubMed
  33. Obesity (Silver Spring). 2013 Mar;21(3):E229-35 - PubMed
  34. Nutrients. 2019 Mar 21;11(3): - PubMed
  35. Br J Nutr. 2003 Oct;90(4):823-7 - PubMed
  36. Int J Obes (Lond). 2012 Nov;36(11):1463-71 - PubMed
  37. J Nutr. 2006 Jun;136(6):1604-9 - PubMed
  38. Am J Clin Nutr. 2011 May;93(5):984-96 - PubMed
  39. N Engl J Med. 2010 Sep 30;363(14):1341-50 - PubMed

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