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Arch Iran Med. 2021 May 01;24(5):409-418. doi: 10.34172/aim.2021.59.

Advances in Alternative and Integrative Medicine in the Treatment of Depression: A Review of the Evidence.

Archives of Iranian medicine

Ahmad Shamabadi, Shahin Akhondzadeh

Affiliations

  1. Psychiatric Research Center, Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences, Tehran, Iran.

PMID: 34196207 DOI: 10.34172/aim.2021.59

Abstract

Depression is a chronic and debilitating psychiatric disorder that affects 300 million people worldwide. Pharmacotherapy is one of the treatments. Due to delay in initiating treatment efficacy and the incomplete response to mono-drug therapy in one-third of patients, new approaches need to be considered. One of the ways to overcome this resistance to treatment and to enhance standard medical practice is to add complementary medicines. We aimed to document research progress from studies on integrative medicine for the treatment of depression. Review of PubMed and Scopus databases on the topic and a personal collection of the relevant publications are the sources for this study. Some of the nutraceuticals and complementary medicines in the treatment of depression will be reviewed. Supplements discussed in this review include S-adenosyl-methionine (SAMe),

© 2021 The Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Keywords: Antidepressive agents; Complementary therapies; Herbal medicine; Nutraceuticals; Traditional medicine

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