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Ibrahim A, Soliman WM, Mesbah BEM, et al. Left ventricular dysfunction and cardiac autonomic imbalance in children with drug-resistant epilepsy. Epilepsy Res. 2021;176:106709doi: 10.1016/j.eplepsyres.2021.106709.
Ibrahim, A., Soliman, W. M., Mesbah, B. E. M., & Salem, A. S. (2021). Left ventricular dysfunction and cardiac autonomic imbalance in children with drug-resistant epilepsy. Epilepsy research, 176106709. https://doi.org/10.1016/j.eplepsyres.2021.106709
Ibrahim, Ahmed, et al. "Left ventricular dysfunction and cardiac autonomic imbalance in children with drug-resistant epilepsy." Epilepsy research vol. 176 (2021): 106709. doi: https://doi.org/10.1016/j.eplepsyres.2021.106709
Ibrahim A, Soliman WM, Mesbah BEM, Salem AS. Left ventricular dysfunction and cardiac autonomic imbalance in children with drug-resistant epilepsy. Epilepsy Res. 2021 Oct;176:106709. doi: 10.1016/j.eplepsyres.2021.106709. Epub 2021 Jul 07. PMID: 34252747.
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Epilepsy Res. 2021 Oct;176:106709. doi: 10.1016/j.eplepsyres.2021.106709. Epub 2021 Jul 07.

Left ventricular dysfunction and cardiac autonomic imbalance in children with drug-resistant epilepsy.

Epilepsy research

Ahmed Ibrahim, Walaa M Soliman, Badr El-Din M Mesbah, Ahmed S Salem

Affiliations

  1. Department of Pediatrics, Faculty of Medicine, Suez Canal University, Egypt. Electronic address: [email protected].
  2. Department of Pediatrics, Faculty of Medicine, Suez Canal University, Egypt.
  3. Department of Cardiology, Faculty of Medicine, Suez Canal University, Egypt.

PMID: 34252747 DOI: 10.1016/j.eplepsyres.2021.106709

Abstract

BACKGROUND: Resistance to antiepileptic drug treatment increases the risk of comorbidities and mortality due to a cardio-autonomic imbalance and left ventricular (LV) dysfunction.

OBJECTIVE: To assess the prevalence of LV dysfunction and cardio-autonomic imbalance in children with drug-resistant epilepsy (DRE).

PATIENTS AND METHODS: This cross-sectional study included 40 children with DRE and 40 healthy age- and sex-matched controls. LV function was evaluated by M-mode, two-dimensional, pulse-wave Doppler echocardiography, and tissue Doppler imaging (TDI). Cardio-autonomic function was assessed by 24 -h Holter monitoring of heart rate variability.

RESULTS: All time domain measures were significantly lower in the epilepsy group than in the control group (all Ps<0.01). Additionally, the mean high frequency (HF) parameters were significantly lower (P = 0.035), whereas the mean low frequency (LF) parameters and the LF/HF ratio were significantly higher (P < 0.001) in the epilepsy group than in the control group. LV function did not differ between groups regarding all standard echocardiographic parameters. There was evidence of subclinical LVdysfunction by tissue doppler among the epileptic group, as evidenced by the elevated Myocardial Performance Index, isovolumetric relaxation time and mitral E/Em ratio. There was no significant correlation between the duration of epilepsy or seizure frequency with any cardiac abnormality.

CONCLUSIONS: Children with DRE exhibited cardio-autonomic and subclinical LV dysfunction, independent of the duration of epilepsy, frequency, and seizure type.

Copyright © 2021 Elsevier B.V. All rights reserved.

Keywords: Autonomic dysfunction; Drug-resistance; Echocardiography; Epilepsy; Left ventricular dysfunction

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