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Mazo CE, D'Lugos AC, Sweeney KR, et al. The effects of acute aerobic and resistance exercise on mTOR signaling and autophagy markers in untrained human skeletal muscle. Eur J Appl Physiol. 2021;121(10):2913-2924doi: 10.1007/s00421-021-04758-6.
Mazo, C. E., D'Lugos, A. C., Sweeney, K. R., Haus, J. M., Angadi, S. S., Carroll, C. C., & Dickinson, J. M. (2021). The effects of acute aerobic and resistance exercise on mTOR signaling and autophagy markers in untrained human skeletal muscle. European journal of applied physiology, 121(10), 2913-2924. https://doi.org/10.1007/s00421-021-04758-6
Mazo, Corey E, et al. "The effects of acute aerobic and resistance exercise on mTOR signaling and autophagy markers in untrained human skeletal muscle." European journal of applied physiology vol. 121,10 (2021): 2913-2924. doi: https://doi.org/10.1007/s00421-021-04758-6
Mazo CE, D'Lugos AC, Sweeney KR, Haus JM, Angadi SS, Carroll CC, Dickinson JM. The effects of acute aerobic and resistance exercise on mTOR signaling and autophagy markers in untrained human skeletal muscle. Eur J Appl Physiol. 2021 Oct;121(10):2913-2924. doi: 10.1007/s00421-021-04758-6. Epub 2021 Jul 01. PMID: 34196787.
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Eur J Appl Physiol. 2021 Oct;121(10):2913-2924. doi: 10.1007/s00421-021-04758-6. Epub 2021 Jul 01.

The effects of acute aerobic and resistance exercise on mTOR signaling and autophagy markers in untrained human skeletal muscle.

European journal of applied physiology

Corey E Mazo, Andrew C D'Lugos, Kaylin R Sweeney, Jacob M Haus, Siddhartha S Angadi, Chad C Carroll, Jared M Dickinson

Affiliations

  1. School of Kinesiology, University of Michigan, Ann Arbor, MI, USA.
  2. Department of Physical Therapy, University of Florida, Gainesville, FL, USA.
  3. Arizona State University, Phoenix, AZ, USA.
  4. Department of Kinesiology, University of Virginia, Charlottesville, VA, USA.
  5. College of Health and Human Sciences, Purdue University, West Lafayette, IN, USA.
  6. Department of Health Sciences, Central Washington University, 400 E University Way, Ellensburg, WA, 98926, USA. [email protected].

PMID: 34196787 DOI: 10.1007/s00421-021-04758-6

Abstract

PURPOSE: Aerobic (AE) and resistance (RE) exercise elicit unique adaptations in skeletal muscle. The purpose here was to compare the post-exercise response of mTOR signaling and select autophagy markers in skeletal muscle to acute AE and RE.

METHODS: In a randomized, cross-over design, six untrained men (27 ± 3 years) completed acute AE (40 min cycling, 70% HRmax) and RE (8 sets, 10 repetitions, 65% 1RM). Muscle biopsies were taken at baseline, and at 1 h and 4 h following each exercise. Western blot analyses were performed to examine total and phosphorylated protein levels. Upstream regulator analyses of skeletal muscle transcriptomics were performed to discern the predicted activation states of mTOR and FOXO3.

RESULTS: Compared to AE, acute RE resulted in greater phosphorylation (P < 0.05) of mTOR

CONCLUSION: Both acute AE and RE stimulate mTOR signaling and similarly impact select markers of autophagy. These findings indicate the early adaptive response of untrained human skeletal muscle to divergent exercise modes is not likely mediated through large differences in mTOR signaling or autophagy.

© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

Keywords: Anabolic; Catabolic; Cell signaling; Endurance; Hypertrophy; Weightlifting

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