Display options
Cite
Vafadar Ghasemi L, Behnam Rassouli M, Matin MM, et al. Benfotiamine reduced collagen IV contents of sciatic nerve in hyperglycemic rats. J Diabetes Metab Disord. 2021;20(1):21-30doi: 10.1007/s40200-020-00666-2.
Vafadar Ghasemi, L., Behnam Rassouli, M., Matin, M. M., & Mahdavi-Shahri, N. (2021). Benfotiamine reduced collagen IV contents of sciatic nerve in hyperglycemic rats. Journal of diabetes and metabolic disorders, 20(1), 21-30. https://doi.org/10.1007/s40200-020-00666-2
Vafadar Ghasemi, Leila, et al. "Benfotiamine reduced collagen IV contents of sciatic nerve in hyperglycemic rats." Journal of diabetes and metabolic disorders vol. 20,1 (2021): 21-30. doi: https://doi.org/10.1007/s40200-020-00666-2
Vafadar Ghasemi L, Behnam Rassouli M, Matin MM, Mahdavi-Shahri N. Benfotiamine reduced collagen IV contents of sciatic nerve in hyperglycemic rats. J Diabetes Metab Disord. 2021 Feb 20;20(1):21-30. doi: 10.1007/s40200-020-00666-2. eCollection 2021 Jun. PMID: 34222057; PMCID: PMC8212243.
Copy Download .nbib Format: NLM
Share it on

J Diabetes Metab Disord. 2021 Feb 20;20(1):21-30. doi: 10.1007/s40200-020-00666-2. eCollection 2021 Jun.

Benfotiamine reduced collagen IV contents of sciatic nerve in hyperglycemic rats.

Journal of diabetes and metabolic disorders

Leila Vafadar Ghasemi, Morteza Behnam Rassouli, Maryam M Matin, Naser Mahdavi-Shahri

Affiliations

  1. Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Azadi Square, Mashhad, Iran.
  2. Department of Biology, Faculty of Sciences, University of Zabol, Zabol, Iran.
  3. Novel Diagnostics and Therapeutics Research Group, Institute of Biotechnology, Ferdowsi University of Mashhad, Mashhad, Iran.

PMID: 34222057 PMCID: PMC8212243 DOI: 10.1007/s40200-020-00666-2

Abstract

BACKGROUND: Neuropathy as a common complication of hyperglycemia in diabetic patients is probably caused by metabolic and structural changes in extracellular matrix (ECM) of peripheral nerves. This study was designed to evaluate the effects of benfotiamine (BT) on the structural, biological and mechanical characteristics of rat sciatic nerve in hyperglycemic condition.

MATERIALS AND METHODS: Forty eight adult male Wistar rats were assigned to 6 groups (n = 8): control (healthy rats with no treatment; C), positive control (healthy rats received BT treatment; B), negative control groups 1&2 (hyperglycemic rats kept for 4 and/or 8 weeks; 4WD and 8WD, respectively) and experimental groups 1&2 (hyperglycemic rats treated by daily oral gavage of 100 mg kg

RESULTS: In comparison to control groups, in 4WD and 8WD groups the amount of type IV collagen was increased, the structure of myelin sheath and nerve fibers were extensively altered and the tensile strength was significantly decreased (

CONCLUSIONS: It seems that BT treatment may rescue the sciatic nerve from the hyperglycemic-induced ECM structural abnormality. This beneficial advantage of BT is likely exerted through the modification of glucose metabolism pathways.

© Springer Nature Switzerland AG 2020.

Keywords: Benfotiamine; Collagen IV; Diabetes; Sciatic nerve; Tensile strength

Conflict of interest statement

Conflict of interestThe authors declare no conflict of interest.

References

  1. J Clin Med Res. 2012 Jun;4(3):153-60 - PubMed
  2. EMBO J. 1991 Nov;10(11):3137-46 - PubMed
  3. J Neuropathol Exp Neurol. 2006 Dec;65(12):1118-25 - PubMed
  4. Molecules. 2015 Feb 16;20(2):3309-34 - PubMed
  5. Ophthalmic Res. 2012;47(4):189-94 - PubMed
  6. J Anat. 2002 Aug;201(2):185-92 - PubMed
  7. J Neurol Neurosurg Psychiatry. 1977 Nov;40(11):1072-82 - PubMed
  8. Diabetes. 2008 Jan;57(1):181-9 - PubMed
  9. Exp Clin Endocrinol Diabetes. 2008 Nov;116(10):600-5 - PubMed
  10. Acta Neuropathol. 2000 May;99(5):539-46 - PubMed
  11. Acta Diabetol. 2008 Sep;45(3):131-41 - PubMed
  12. Diabetes. 2009 Dec;58(12):2893-903 - PubMed
  13. J Pharmacol Exp Ther. 2003 Jun;305(3):1045-53 - PubMed
  14. Neuropathol Appl Neurobiol. 1989 Jul-Aug;15(4):339-55 - PubMed
  15. J Biol Chem. 2006 Apr 7;281(14):9307-13 - PubMed
  16. Endocrinol Metab Clin North Am. 2013 Dec;42(4):747-87 - PubMed
  17. Diabetes. 1994 Jun;43(6):836-41 - PubMed
  18. J Neurol Sci. 2004 Feb 15;217(2):157-63 - PubMed
  19. J Craniofac Surg. 2014 Jul;25(4):1510-4 - PubMed
  20. Hormones (Athens). 2005 Jan-Mar;4(1):28-37 - PubMed
  21. Acta Neuropathol. 2006 Nov;112(5):627-32 - PubMed
  22. J Clin Endocrinol Metab. 2008 Apr;93(4):1143-52 - PubMed
  23. J Surg Res. 2003 Oct;114(2):133-9 - PubMed
  24. J Cell Biol. 1982 Oct;95(1):340-4 - PubMed
  25. J Mater Sci Mater Med. 2014 May;25(5):1283-91 - PubMed
  26. J Diabetes Investig. 2016 May;7(3):404-12 - PubMed
  27. Brain Res. 1998 Jun 8;795(1-2):44-54 - PubMed
  28. Aging Dis. 2016 Jan 02;7(1):90-110 - PubMed
  29. EMBO J. 1993 Dec;12(12):4795-802 - PubMed
  30. Acta Diabetol. 2016 Apr;53(2):317-22 - PubMed
  31. J Neurol. 2002 Apr;249(4):424-31 - PubMed
  32. Int J Mol Sci. 2010 Jan 28;11(2):407-26 - PubMed
  33. BMC Pharmacol. 2008 Jun 12;8:10 - PubMed
  34. J Biomech. 2004 Jun;37(6):879-88 - PubMed
  35. Muscle Nerve. 1983 Oct;6(8):561-5 - PubMed
  36. Diabetes Metab Res Rev. 2004 Sep-Oct;20(5):369-82 - PubMed
  37. Biomol Concepts. 2016 Dec 1;7(5-6):293-309 - PubMed
  38. Int J Clin Pharmacol Ther. 1998 Apr;36(4):216-21 - PubMed
  39. Diabetes. 1984 Mar;33(3):244-50 - PubMed
  40. J Diabetes Investig. 2011 Jan 24;2(1):18-32 - PubMed

Publication Types