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Pereira BFM, Pereira MU, Ferreira RG, et al. Dietary exposure assessment to macrolide antimicrobial residues through infant formulas marketed in Brazil. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2021;38(10):1672-1688doi: 10.1080/19440049.2021.1933204.
Pereira, B. F. M., Pereira, M. U., Ferreira, R. G., & Spisso, B. F. (2021). Dietary exposure assessment to macrolide antimicrobial residues through infant formulas marketed in Brazil. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 38(10), 1672-1688. https://doi.org/10.1080/19440049.2021.1933204
Pereira, Bianca Figueiredo de Mendonça, et al. "Dietary exposure assessment to macrolide antimicrobial residues through infant formulas marketed in Brazil." Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment vol. 38,10 (2021): 1672-1688. doi: https://doi.org/10.1080/19440049.2021.1933204
Pereira BFM, Pereira MU, Ferreira RG, Spisso BF. Dietary exposure assessment to macrolide antimicrobial residues through infant formulas marketed in Brazil. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2021 Oct;38(10):1672-1688. doi: 10.1080/19440049.2021.1933204. Epub 2021 Jul 13. PMID: 34254896.
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Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2021 Oct;38(10):1672-1688. doi: 10.1080/19440049.2021.1933204. Epub 2021 Jul 13.

Dietary exposure assessment to macrolide antimicrobial residues through infant formulas marketed in Brazil.

Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment

Bianca Figueiredo de Mendonça Pereira, Mararlene Ulberg Pereira, Rosana Gomes Ferreira, Bernardete Ferraz Spisso

Affiliations

  1. Instituto Nacional de Controle de Qualidade em Saúde, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil (INCQS/FIOCRUZ), Rio de Janeiro, Brazil.

PMID: 34254896 DOI: 10.1080/19440049.2021.1933204

Abstract

Macrolides are critically important antimicrobials for both human and animal health and should be prioritized in risk assessments, as inappropriate use may result in antimicrobial resistance. The antimicrobials erythromycin, oleandomycin, spiramycin, tilmicosin and tylosin were analysed in infant formula samples by HPLC-MS/MS using a validated analytical method based on a modified QuEChERS extraction. The results of the occurrence study were employed to perform a dietary exposure assessment of infants to residues. In a total of 30 analysed samples, 73% contained spiramycin residues and 27%, tilmicosin residues. Calculated daily intakes ranged from 1.47 × 10

Keywords: LC-MS/MS; Macrolides; antimicrobial resistance; food contaminants; food control; food safety; infant nutrition; modified alkaline QuEChERS; risk assessment

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