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Di Trani N, Liu HC, Qi R, et al. Long-acting tunable release of amlodipine loaded PEG-PCL micelles for tailored treatment of chronic hypertension. Nanomedicine. 2021;37:102417doi: 10.1016/j.nano.2021.102417.
Di Trani, N., Liu, H. C., Qi, R., Viswanath, D. I., Liu, X., Chua, C. Y. X., & Grattoni, A. (2021). Long-acting tunable release of amlodipine loaded PEG-PCL micelles for tailored treatment of chronic hypertension. Nanomedicine : nanotechnology, biology, and medicine, 37102417. https://doi.org/10.1016/j.nano.2021.102417
Di Trani, Nicola, et al. "Long-acting tunable release of amlodipine loaded PEG-PCL micelles for tailored treatment of chronic hypertension." Nanomedicine : nanotechnology, biology, and medicine vol. 37 (2021): 102417. doi: https://doi.org/10.1016/j.nano.2021.102417
Di Trani N, Liu HC, Qi R, Viswanath DI, Liu X, Chua CYX, Grattoni A. Long-acting tunable release of amlodipine loaded PEG-PCL micelles for tailored treatment of chronic hypertension. Nanomedicine. 2021 Oct;37:102417. doi: 10.1016/j.nano.2021.102417. Epub 2021 Jun 22. PMID: 34171469; PMCID: PMC8475571.
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Nanomedicine. 2021 Oct;37:102417. doi: 10.1016/j.nano.2021.102417. Epub 2021 Jun 22.

Long-acting tunable release of amlodipine loaded PEG-PCL micelles for tailored treatment of chronic hypertension.

Nanomedicine : nanotechnology, biology, and medicine

Nicola Di Trani, Hsuan-Chen Liu, Ruogu Qi, Dixita I Viswanath, Xuewu Liu, Corrine Ying Xuan Chua, Alessandro Grattoni

Affiliations

  1. Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX, USA; University of Chinese Academy of Science (UCAS), Beijing, China.
  2. Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX, USA.
  3. Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX, USA; Texas A&M University-College of Medicine, Bryan, TX, USA.
  4. Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX, USA; Department of Surgery, Houston Methodist Hospital, Houston, TX, USA; Department of Radiation Oncology, Houston Methodist Hospital, Houston, TX, USA. Electronic address: [email protected].

PMID: 34171469 PMCID: PMC8475571 DOI: 10.1016/j.nano.2021.102417

Abstract

Hypertension is a chronic condition that requires lifelong therapeutic management. Strict adherence to drug administration timing improves efficacy, while poor adherence leads to safety concerns. In light of these challenges, we present a nanofluidic technology that enables long-acting drug delivery with tunable timing of drug administration using buried gate electrodes in nanochannels. We developed a poly(ethylene glycol) methyl ether-block-poly(ε-caprolactone) (PEG-PCL)-based micellar formulation of amlodipine besylate, a calcium channel blocker for hypertension treatment. The electrostatically charged PEG-PCL micellar formulation enhanced drug solubility and rendered amlodipine responsive to electrostatic release gating in nanochannels for sustained release at clinically relevant therapeutic dose. Using a low-power (<3 VDC) gating potential, we demonstrated tunable release of amlodipine-loaded micelles. Additionally, we showed that the released drug maintained biological activity via calcium ion blockade in vitro. This study represents a proof of concept for the potential applicability of our strategy for chronotherapeutic management of hypertension.

Copyright © 2021 Elsevier Inc. All rights reserved.

Keywords: Amlodipine; Controlled release; Drug delivery; Hypertension; Micelle encapsulation

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