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Pharmaceutics. 2021 Jun 04;13(6). doi: 10.3390/pharmaceutics13060836.

Effectiveness of Antimicrobial Photodynamic Therapy in the Treatment of Periodontitis: A Systematic Review and Meta-Analysis of In Vivo Human Randomized Controlled Clinical Trials.

Pharmaceutics

Snehal Dalvi, Stefano Benedicenti, Tudor Sălăgean, Ioana Roxana Bordea, Reem Hanna

Affiliations

  1. Department of Surgical Sciences and Integrated Diagnostics, Laser Therapy Centre, University of Genoa, Viale Benedetto XV, 6, 16132 Genoa, Italy.
  2. Department of Periodontology, Swargiya Dadasaheb Kalmegh Smruti Dental College and Hospital, Nagpur 441110, India.
  3. Department of Land Measurements and Exact Sciences, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, 400372 Cluj-Napoca, Romania.
  4. Department of Oral Rehabilitation, "Iuliu Ha?ieganu" University of Medicine and Pharmacy Cluj-Napoca, 400012 Cluj-Napoca, Romania.
  5. Department of Oral Surgery, Dental Institute, King's College Hospital NHS Foundation Trust, London SE5 9RS, UK.

PMID: 34200078 PMCID: PMC8228221 DOI: 10.3390/pharmaceutics13060836

Abstract

This systematic review and meta-analysis evaluated antimicrobial photodynamic therapy (aPDT) efficacy in periodontitis. The review protocol was conducted in accordance with PRISMA statements, Cochrane Collaboration recommendations and is registered in PROSPERO (CRD 42020161516). Electronic and hand search strategies were undertaken to gather data on in vivo human RCTs followed by qualitative analysis. Differences in probing pocket depth (PPD) and clinical attachment level (CAL) were calculated with 95% confidence intervals and pooled in random effects model at three and six months. Heterogeneity was analyzed, using Q and I

Keywords: antimicrobial photodynamic therapy; meta-analysis; periodontitis; scaling and root planing; systematic review

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