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Yu WY, Gao CX, Zhang HH, et al. Herbal Active Ingredients: Potential for the Prevention and Treatment of Acute Lung Injury. Biomed Res Int. 2021;2021:5543185doi: 10.1155/2021/5543185.
Yu, W. Y., Gao, C. X., Zhang, H. H., Wu, Y. G., & Yu, C. H. (2021). Herbal Active Ingredients: Potential for the Prevention and Treatment of Acute Lung Injury. BioMed research international, 20215543185. https://doi.org/10.1155/2021/5543185
Yu, Wen-Ying, et al. "Herbal Active Ingredients: Potential for the Prevention and Treatment of Acute Lung Injury." BioMed research international vol. 2021 (2021): 5543185. doi: https://doi.org/10.1155/2021/5543185
Yu WY, Gao CX, Zhang HH, Wu YG, Yu CH. Herbal Active Ingredients: Potential for the Prevention and Treatment of Acute Lung Injury. Biomed Res Int. 2021 Jun 22;2021:5543185. doi: 10.1155/2021/5543185. eCollection 2021. PMID: 34258266; PMCID: PMC8245226.
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Biomed Res Int. 2021 Jun 22;2021:5543185. doi: 10.1155/2021/5543185. eCollection 2021.

Herbal Active Ingredients: Potential for the Prevention and Treatment of Acute Lung Injury.

BioMed research international

Wen-Ying Yu, Chun-Xiao Gao, Huan-Huan Zhang, Yue-Guo Wu, Chen-Huan Yu

Affiliations

  1. College of Pharmacy, Hangzhou Medical College, Hangzhou, China.
  2. Key Laboratory of Experimental Animal and Safety Evaluation of Zhejiang Province, Hangzhou Medical College, Hangzhou, China.
  3. Institute of Cancer and Basic Medicine, Chinese Academy of Sciences, Hangzhou, China.

PMID: 34258266 PMCID: PMC8245226 DOI: 10.1155/2021/5543185

Abstract

Acute lung injury (ALI) is a life-threatening clinical syndrome with high morbidity and mortality. The main pathological features of ALI are increased alveolar-capillary membrane permeability, edema, uncontrolled migration of neutrophils to the lungs, and diffuse alveolar damage, resulting in acute hypoxemic respiratory failure. Glucocorticoids, aspirin, and other anti-inflammatory drugs are commonly used to treat ALI. Respiratory supports, such as a ventilator, are used to alleviate hypoxemia. Many treatment methods are available, but they cannot significantly ameliorate the quality of life of patients with ALI and reduce mortality rates. Herbal active ingredients, such as flavonoids, terpenoids, saponins, alkaloids, and quinonoids, exhibit advantages for ALI prevention and treatment, but the underlying mechanism needs further study. This paper summarizes the role of herbal active ingredients in anti-ALI therapy and progresses in the understanding of their mechanisms. The work also provides some references and insights for the discovery and development of novel drugs for ALI prevention and treatment.

Copyright © 2021 Wen-Ying Yu et al.

Conflict of interest statement

The authors have no conflicts of interest to declare.

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