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Torkamand F, Aghakhani-Lobnani AM, Khaleghzadeh-Ahangar H, et al. The role of dentate gyrus dopaminergic receptors in the lateral hypothalamic-induced antinociception during persistent inflammatory pain in male rats. Behav Brain Res. 2021;412:113434doi: 10.1016/j.bbr.2021.113434.
Torkamand, F., Aghakhani-Lobnani, A. M., Khaleghzadeh-Ahangar, H., Rashvand, M., Rahban, M., & Haghparast, A. (2021). The role of dentate gyrus dopaminergic receptors in the lateral hypothalamic-induced antinociception during persistent inflammatory pain in male rats. Behavioural brain research, 412113434. https://doi.org/10.1016/j.bbr.2021.113434
Torkamand, Farbod, et al. "The role of dentate gyrus dopaminergic receptors in the lateral hypothalamic-induced antinociception during persistent inflammatory pain in male rats." Behavioural brain research vol. 412 (2021): 113434. doi: https://doi.org/10.1016/j.bbr.2021.113434
Torkamand F, Aghakhani-Lobnani AM, Khaleghzadeh-Ahangar H, Rashvand M, Rahban M, Haghparast A. The role of dentate gyrus dopaminergic receptors in the lateral hypothalamic-induced antinociception during persistent inflammatory pain in male rats. Behav Brain Res. 2021 Aug 27;412:113434. doi: 10.1016/j.bbr.2021.113434. Epub 2021 Jun 24. PMID: 34175356.
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Behav Brain Res. 2021 Aug 27;412:113434. doi: 10.1016/j.bbr.2021.113434. Epub 2021 Jun 24.

The role of dentate gyrus dopaminergic receptors in the lateral hypothalamic-induced antinociception during persistent inflammatory pain in male rats.

Behavioural brain research

Farbod Torkamand, Ali-Mohammad Aghakhani-Lobnani, Hossein Khaleghzadeh-Ahangar, Mina Rashvand, Mohammad Rahban, Abbas Haghparast

Affiliations

  1. Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
  2. Department of Physiology, School of Medicine, Babol University of Medical Sciences, Babol, Iran; Neuroscience Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran. Electronic address: [email protected].
  3. Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  4. Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: [email protected].

PMID: 34175356 DOI: 10.1016/j.bbr.2021.113434

Abstract

The lateral hypothalamus (LH) is one of the key brain areas involved in pain modulation. Also, the dentate gyrus (DG) of the hippocampus expresses various receptors, including dopaminergic receptors. Dopaminergic receptors play a key role in pain transmission and modulation within the brain. The present study aimed to investigate the involvement of DG dopaminergic receptors in the LH-induced antinociception during the presence of inflammatory pain. Male Wistar rats were used in this study. Cannulae were unilaterally implanted in their skull for microinjections into the LH and DG. The LH was chemically stimulated by carbachol injection (250 nM/0.5 μl saline). In separate groups, different doses (0.25, 1, and 4 μg/0.5 μl vehicle) of the D1- and D2-like dopamine receptor antagonists (SCH23390 and Sulpiride, respectively) were microinjected into the DG, 5 min prior to intra-LH injection of carbachol. Five min after the second injection, formalin test as a persistent inflammatory pain model in animals was done in all rats. The results revealed that carbachol could induce antinociception following formalin injection into rat's hind paw. The 4 μg dose of both antagonists significantly reduced the LH stimulation-induced antinociception in both phases of formalin pain responses. Although the 1 μg dose of sulpiride significantly reduced antinociception during both phases, 1 μg SCH23390 could only reduce this antinociception during the late phase. These findings demonstrate the involvement of DG dopaminergic receptors in the LH-induced antinociception. The results also suggest that the effectiveness of DG dopaminergic receptors is more pronounced during the late phase of formalin-induced pain responses.

Copyright © 2021 Elsevier B.V. All rights reserved.

Keywords: D1-like dopamine receptor; D2-like dopamine receptor; Dentate gyrus of hippocampus; Formalin test; Lateral hypothalamus; Pain

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