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Gila-Diaz A, Carrillo GH, Singh P, et al. Specialized Pro-Resolving Lipid Mediators in Neonatal Cardiovascular Physiology and Diseases. Antioxidants (Basel). 2021;10(6)doi: 10.3390/antiox10060933.
Gila-Diaz, A., Carrillo, G. H., Singh, P., & Ramiro-Cortijo, D. (2021). Specialized Pro-Resolving Lipid Mediators in Neonatal Cardiovascular Physiology and Diseases. Antioxidants (Basel, Switzerland), 10(6), . https://doi.org/10.3390/antiox10060933
Gila-Diaz, Andrea, et al. "Specialized Pro-Resolving Lipid Mediators in Neonatal Cardiovascular Physiology and Diseases." Antioxidants (Basel, Switzerland) vol. 10,6 (2021). doi: https://doi.org/10.3390/antiox10060933
Gila-Diaz A, Carrillo GH, Singh P, Ramiro-Cortijo D. Specialized Pro-Resolving Lipid Mediators in Neonatal Cardiovascular Physiology and Diseases. Antioxidants (Basel). 2021 Jun 08;10(6). doi: 10.3390/antiox10060933. PMID: 34201378; PMCID: PMC8229722.
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Antioxidants (Basel). 2021 Jun 08;10(6). doi: 10.3390/antiox10060933.

Specialized Pro-Resolving Lipid Mediators in Neonatal Cardiovascular Physiology and Diseases.

Antioxidants (Basel, Switzerland)

Andrea Gila-Diaz, Gloria Herranz Carrillo, Pratibha Singh, David Ramiro-Cortijo

Affiliations

  1. Department of Physiology, Faculty of Medicine, Universidad Autónoma de Madrid, C/Arzobispo Morcillo 2, 28029 Madrid, Spain.
  2. Division of Neonatology, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), C/Profesor Martin Lagos s/n, 28040 Madrid, Spain.
  3. Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.

PMID: 34201378 PMCID: PMC8229722 DOI: 10.3390/antiox10060933

Abstract

Cardiovascular disease remains a leading cause of mortality worldwide. Unresolved inflammation plays a critical role in cardiovascular diseases development. Specialized Pro-Resolving Mediators (SPMs), derived from long chain polyunsaturated fatty acids (LCPUFAs), enhances the host defense, by resolving the inflammation and tissue repair. In addition, SPMs also have anti-inflammatory properties. These physiological effects depend on the availability of LCPUFAs precursors and cellular metabolic balance. Most of the studies have focused on the impact of SPMs in adult cardiovascular health and diseases. In this review, we discuss LCPUFAs metabolism, SPMs, and their potential effect on cardiovascular health and diseases primarily focusing in neonates. A better understanding of the role of these SPMs in cardiovascular health and diseases in neonates could lead to the development of novel therapeutic approaches in cardiovascular dysfunction.

Keywords: cardiovascular diseases; long chain polyunsaturated fatty acids; newborn; oxylipins; premature infant; specialized pro-resolving mediators

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